Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elizabeth B. Fraser-Smith"'
Publikováno v:
Antiviral Research. 24:361-364
Autor:
Anthony C. Allison, Ruth A. Pecyk, Mary Welch, Anthony R. Hayward, Gayle Nakano, Noelene E. Byars, Elizabeth B Fraser-Smith, Rae Lyn Burke
Publikováno v:
Vaccine. 12:200-209
Guinea pigs were immunized with glycoprotein gD-2t in SAF-m or saline, then challenged with herpes simplex virus, type 2 (HSV-2). Animals given gD-2t in SAF-m had higher anti-gD-2t antibodies, fewer and less severe vaginal lesions, and decreased gang
Publikováno v:
Antiviral Research. 17:145-156
The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in
Publikováno v:
Tetrahedron Letters. 33:37-40
4′-Cyanothymidine inhibits HIV in A301 (Alex) cells with an IC 50 of 0.002 μM. The uridine and cytidine analogs show similiar potencies.
Autor:
Randall C. Schatzman, Elizabeth B. Fraser-Smith, Vicki R. Freitas, Sophie Chiu, Seth Michelson
Publikováno v:
Antiviral research. 21(4)
In cultured MRC-5 cells, ganciclovir (GCV) alone had good activity against both the established AD169 strain (IC 50 8 and 9 μM) and a clinical isolate (IC 50 14 μM) of human cytomegalovirus (CMV), while 3′-azido-3′-deoxythymidine (AZT) was rela
Publikováno v:
Antiviral research. 20(1)
In MRC-5 cell cultures, the efficacy of the acyclic nucleoside ganciclovir (GCV) against human cytomegalovirus (CMV) was unaffected when combined with either amphotericin B (AMP B), ketoconazole (KCZ), dapsone (DAP), or trimethoprim/sulfamethoxazole
Autor:
David G. Loughhead, Stanford Bingham, Mark A. Emanuel, Robert James Weikert, Anthony L. Poulton, Peter H. Nelson, Elizabeth B. Fraser-Smith
Publikováno v:
Journal of medicinal chemistry. 34(5)
Reaction of 3-amino derivatives of the nematocides tetramisole and levamisole with variously substituted benzoylisocyanates gave a se'ries of benzoylyureas I which were tested for activity against helminths and ectoparasites. Compounds bearing 2,6-di
Publikováno v:
Immunopharmacology. 16:151-155
The effect of ketorolac tromethamine, a nonsteroidal anti-inflammatory drug, on normal phagocytosis has been studied. When peritoneal macrophages, taken from mice treated intraperitoneally 4 times daily for 7 days with 2 mg ketorolac per day, were cu
Publikováno v:
Antiviral Research. 5:137-144
The acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) and recombinant mouse interferon gamma (rMuIFN-gamma) were evaluated for their efficacy alone and in combination against a herpes simplex virus type 2 systemic infection in mice.
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 4:321-326
Corticosteroids can exacerbate viral ocular infections. Ketorolac tromethamine is an effective nonsteroidal anti-inflammatory agent that may be a useful substitute for corticosteroids following ocular surgery. In this study, rabbits ocularly infected