Výsledky vyhledávání - "Elizabeth A. Smethurst"

Supplementary Figure 5 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Autor: Adrian L. Harris, Michael J.O. Wakelam, Eyal Gottlieb, Almut Schulze, Susan E. Critchlow, Eric O. Aboagye, Barrie Peck, Zachary T. Schug, Elizabeth A. Smethurst, Qifeng Zhang, Syed Haider, Alessandro Valli, Dylan T. Jones

Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. FASN and B. DGAT inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296bb68cd5c019936a1ef3f8f3f2c884
https://doi.org/10.1158/1535-7163.22508365

Zobrazit plný text záznamu

Supplementary Figure 4 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60daf610bff0e2bf95b43c86f86c0cb4
https://doi.org/10.1158/1535-7163.22508368.v1

Zobrazit plný text záznamu

Supplementary Figure 6 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. ACC and B. PDHK inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc03940dab83b7d2ca0a563a7288b02
https://doi.org/10.1158/1535-7163.22508362.v1

Zobrazit plný text záznamu

Supplementary Figure 3 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

GI50 calculation of spheroids treated with inhibitors. (A) MDA-MB-468 on day 8 and (B) PC3 spheroids on day 12 treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K, Akt and mTOR. Between 5 and 15 sph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7333ce6954bf5cbb452d5e1691c771
https://doi.org/10.1158/1535-7163.22508371

Zobrazit plný text záznamu

Supplementary Figure 1 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Chemical structure of drugs that inhibit metabolic enzymes FASN (AZ22), ACC (AZ52), DGAT (AZ17), PDHK (AZ30), and cell signalling kinase enzymes PI3K (AZ46), AKT (AZ28) and mTOR (AZ64).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4771a84b6bf121110556ffa4dcb40491
https://doi.org/10.1158/1535-7163.22508377

Zobrazit plný text záznamu

Supplementary Figure 2 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Two dimensional CyQuant cell proliferation assay of (A) MDA-MB-468 and (B) PC3 cells following 3 days of treatment under normoxic and hypoxic conditions with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bde0d00b5065de6ca244068f1993d0
https://doi.org/10.1158/1535-7163.22508374

Zobrazit plný text záznamu

Supplementary Figure 7 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Significant differential abundance analysis of lipids as a heat map. A. MDA-MB-468 and B. PC3 spheroids were treated for 4 days with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and kinases PI3K, AKT and mTOR at two different concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6962d0b31b1aaae8cc611b54bcbe6fac
https://doi.org/10.1158/1535-7163.22508359.v1

Zobrazit plný text záznamu

Supplementary Figure 8 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Analysis of saturated, mono-unsaturated and poly-unsaturated phospholipids in MDA-MB-468 and PC3 spheroids. Levels of PC, PE, PI, PS, and SM in MDA-MB-468 and PC3 spheroids treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c1171c50c5fcc5af645d51f686fd61
https://doi.org/10.1158/1535-7163.22508356

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání