Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Elizabeth A. Slee"'
Autor:
Min, He, Elizabeth A, Slee, Mengmeng, Sun, Chunxiu, Hu, Wen-Te, Chang, Guowang, Xu, Xin, Lu, Mei, Wang
Publikováno v:
Journal of Chromatography B. 1211:123491
The Tp53 gene is a well-known tumour suppressor, mutation of which (e.g. prevention of Ser312 phosphorylation) induces deletion or expression of an inactive p53 protein to increase the susceptibility of tumour occurance. However, the role of Tp53 gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8dc7efab4ca2c871122ebaf1fcfa84
https://doi.org/10.1016/j.jchromb.2022.123491
https://doi.org/10.1016/j.jchromb.2022.123491
Autor:
Karolis Leonavicius, Holly Hathrell, Xin Lu, Chris Graham, Kevin Coward, Celine Jones, Anna Vincent, Jemma Garratt, Jonathan Godwin, Nisha Veits, Elizabeth A. Slee, Elizabeth Sandham, Christophe Royer, Tanaya Narendra, Tim Child, Felix Zhou, Shankar Srinivas
During development, pseudostratified epithelia undergo large scale morphogenetic events associated with increased mechanical stress. The molecular mechanisms that maintain tissue integrity in this context are poorly understood. Using a variety of gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::591417adb3546ef5a4898342ccd4e9ab
https://doi.org/10.21203/rs.3.rs-107253/v1
https://doi.org/10.21203/rs.3.rs-107253/v1
Autor:
Robert D. Goldin, Zinaida Dedeić, Xin Lu, Elizabeth A. Slee, Jürgen E. Schneider, Debra J. McAndrew, Kathryn Chung, Gopinath Sutendra, David J. P. Ferguson, Michael J. White, Felix Zhou, Ying Hu
Desmosome components are frequently mutated in cardiac and cutaneous disorders in animals and humans and enhanced inflammation is a common feature of these diseases. Previous studies showed that inhibitor of Apoptosis Stimulating p53 Protein (iASPP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03e9c4b369a0370ea89650844a4d94e
https://doi.org/10.1038/s41418-017-0039-6
https://doi.org/10.1038/s41418-017-0039-6
Autor:
Elizabeth A. Slee, Aude Vernet, Fabrice Prin, A T Collins, Samuel H. Zinner, Craig A. Lygate, Virginie Vives, Dagmar Wieczorek, Arthur S. Aylsworth, Holly Dubbs, Eva Chian-Hui Chen, A M Innes, Shelagh Joss, Pieter M. Pretorius, Jaroslav Zak, Paul D. Miller, Anne Dieux-Coeslier, Dieter Kotzot, Xin Lu, Jürgen E. Schneider, Michael Parker, Edda Haberlandt, Joris Andrieux, Luis F. Escobar, Daryl A. Scott, Y S Choy, Z Zakaria, Megan Tucker, Yves Lacassie, Dorota Szumska, Jill A. Rosenfeld, K R Jun, Timothy J. Mohun
Chromosomal abnormalities are implicated in a substantial number of human developmental syndromes, but for many such disorders little is known about the causative genes. The recently described 1q41q42 microdeletion syndrome is characterized by charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b64e354eb61dafdbafb9e009fcccb36
https://doi.org/10.1038/cdd.2016.76
https://doi.org/10.1038/cdd.2016.76
The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c10bb5c5db50c9d97918c7232ee284a
https://doi.org/10.1038/nrm2451
https://doi.org/10.1038/nrm2451
The fundamental role of apoptosis in tumor prevention and the important role of p53 in this process are now universally recognized. Recently, several families of p53-binding proteins have been shown to influence p53's decision to direct the cells eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9d8c28be5353dd81176c40b24269a3
https://doi.org/10.4161/cc.5.19.3266
https://doi.org/10.4161/cc.5.19.3266
Autor:
Robert D. Goldin, Xin Lu, Barbara Benassi, Indrika Ratnayaka, Shan Zhong, Giovanni Blandino, Elizabeth A. Slee
The tumor suppressor p53 is a master sensor of stress, and posttranslational modifications are key in controlling its stability and transcriptional activities. p53 can be phosphorylated on at least 23 Ser/Thr residues, the majority of which are phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6d1fda436192798175c740475d8421
https://doi.org/10.1073/pnas.1005165107
https://doi.org/10.1073/pnas.1005165107
Autor:
Wenjie Ge, Elizabeth A. Slee, Zinaida Dedeić, Gopinath Sutendra, Caroline Baer, Xingwen Wang, Kunming Zhao, Ying Hu, Xin Lu
Publikováno v:
Oncotarget
An intriguing biological question relating to cell signaling is how the inflammatory mediator NF-kB and the tumour suppressor protein p53 can be induced by similar triggers, like DNA damage or infection, yet have seemingly opposing or sometimes coope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1b3673330e9d1c51f5782bf9d06d05
http://ora.ox.ac.uk/objects/uuid:81f7754a-47f5-4d3d-87a0-e118bd963b4b
http://ora.ox.ac.uk/objects/uuid:81f7754a-47f5-4d3d-87a0-e118bd963b4b
Autor:
Elizabeth A. Slee, Xin Lu
Publikováno v:
Toxicology Letters. 139:81-87
It is well established that p53 is a primary target for mutation in human cancer. p53 carries out the important task of ensuring that damaged DNA is not passed on during cell division, a duty that it performs by either inhibiting the cell cycle or in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39f1e429907a3761df0ae934b77e224
https://doi.org/10.1016/s0378-4274(02)00421-6
https://doi.org/10.1016/s0378-4274(02)00421-6
Publikováno v:
Cell Death & Differentiation. 7:556-565
peer-reviewed BID, a pro-apoptotic Bcl-2 family member, promotes cytochrome c release during apoptosis initiated by CD95L or TNF. Activation of caspase-8 in the latter pathways results in cleavage of BID, translocation of activated BID to mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d16fde69916cde1317e66dd04c1491d
https://doi.org/10.1038/sj.cdd.4400689
https://doi.org/10.1038/sj.cdd.4400689