Targeting the replication initiator of the second Vibrio chromosome: towards generation of vibrionaceae-specific antimicrobial agents.

Autor: Yoshiharu Yamaichi, Stéphane Duigou, Elizabeth A Shakhnovich, Matthew K Waldor

Publikováno v: PLoS Pathogens, Vol 5, Iss 11, p e1000663 (2009)

The Vibrionaceae is comprised of numerous aquatic species and includes several human pathogens, such as Vibrio cholerae, the cause of cholera. All organisms in this family have two chromosomes, and replication of the smaller one depends on rctB, a ge

Externí odkaz: https://doaj.org/article/741d1927dadf47c38b115088e7cfffab

Small-Molecule Inhibitor of Vibrio cholerae Virulence and Intestinal Colonization

Autor: Deborah T. Hung, Elizabeth A. Shakhnovich, John J. Mekalanos, Emily Pierson

Publikováno v: Science. 310:670-674

Increasing antibiotic resistance requires the development of new approaches to combating infection. Virulence gene expression in vivo represents a target for antibiotic discovery that has not yet been explored. A high-throughput, phenotypic screen wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128159d0b1f9ffdd4ef1fb3bfc5ea5fe
https://doi.org/10.1126/science.1116739

Targeting the Replication Initiator of the Second Vibrio Chromosome: Towards Generation of Vibrionaceae-Specific Antimicrobial Agents

Autor: Matthew K. Waldor, Yoshiharu Yamaichi, Elizabeth A. Shakhnovich, Stephane Duigou

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 5, Iss 11, p e1000663 (2009)
PLoS Pathogens, Public Library of Science, 2009, 5 (11), pp.e1000663. ⟨10.1371/journal.ppat.1000663⟩

The Vibrionaceae is comprised of numerous aquatic species and includes several human pathogens, such as Vibrio cholerae, the cause of cholera. All organisms in this family have two chromosomes, and replication of the smaller one depends on rctB, a ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94148dbae57bfad6798e9e90dd0f7e58
http://europepmc.org/articles/PMC2773409

Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae

Autor: Derek Sturtevant, Elizabeth A. Shakhnovich, John J. Mekalanos

Publikováno v: Molecular microbiology. 66(6)

Virstatin is a previously described small molecule inhibitor of Vibrio cholerae virulence. We have demonstrated that the molecule inhibits the activity of the transcriptional activator ToxT, thereby preventing elaboration of the toxin co-regulated pi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4508512d33f5e20760304d43ac24621f
https://pubmed.ncbi.nlm.nih.gov/17986190