Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elizabeth A. Roundhill"'
Autor:
Emma L. O’Dowd, Samuel W. D. Merriel, Vinton W. T. Cheng, Sam Khan, Lynne M. Howells, Dipesh P. Gopal, Elizabeth A. Roundhill, Paul M. Brennan, Philip A. J. Crosbie, Richard D. Neal, Karen Brown, Emma J. Crosbie, David R. Baldwin
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Global annual cancer incidence is forecast to rise to 27.5 M by 2040, a 62% increase from 2018. For most cancers, prevention and early detection are the most effective ways of reducing mortality. This study maps trials in cancer s
Externí odkaz:
https://doaj.org/article/1225c6be837041a58d5618e2cacd19b9
Autor:
Marcus J. Brookes, Elizabeth A. Roundhill, Lee Jeys, Michael Parry, Susan A. Burchill, Kenneth S. Rankin
Publikováno v:
Pediatric Blood & Cancer. 70
Autor:
Emma L O’Dowd, Samuel WD Merriel, Vinton WT Cheng, Sam Khan, Lynne M Howells, Dipesh P Gopal, Elizabeth A Roundhill, Paul M Brennan, Philip AJ Crosbie, Richard D Neal, Karen Brown, Emma J Crosbie, David Baldwin
Background Global annual cancer incidence is forecast to rise to 27.5M by 2040, a 62% rise from 2018. For most cancers, prevention and early detection are the most effective ways of reducing mortality. This study maps trials in cancer screening, prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0b3134fc56a1f0d1c261b82963c272a
https://doi.org/10.21203/rs.3.rs-2378692/v1
https://doi.org/10.21203/rs.3.rs-2378692/v1
Autor:
Marcus J. Brookes, Elizabeth A. Roundhill, Lee Jeys, Michael Parry, Susan A. Burchill, Kenneth S. Rankin
Publikováno v:
Pediatric Blood & Cancer. 69
Ewing sarcoma (ES) is the second most common primary bone malignancy, with an urgent need for new treatments. ES is associated with high rates of progression and relapse, driven by drug-resistant cells capable of migration, self-renewal and single-ce
Autor:
Elizabeth A. Roundhill, Elton J. Vasconcelos, David R. Westhead, Sarah Grissenberger, Martin Distel, Susan A. Burchill
Publikováno v:
Cancer Research. 83:4683-4683
Models that more accurately reflect Ewing sarcoma (ES) will enable the prioritization of novel targeted agents from bench to clinic. To date, development of an ES mouse model have been unsuccessful1 and engraftment of human ES in mice is variable2. C
Autor:
Michael Parry, Mariona Chicon-Bosch, Elizabeth Ann Roundhill, Kenneth S. Rankin, Susan A. Burchill, Alastair Droop, Lee Jeys
Publikováno v:
Cellular Oncology (Dordrecht)
Purpose The development of biomarkers and molecularly targeted therapies for patients with Ewing sarcoma (ES) in order to minimise morbidity and improve outcome is urgently needed. Here, we set out to isolate and characterise patient-derived ES prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0329b940ca7ef2c66695841455aa04df
https://eprints.whiterose.ac.uk/177209/1/Roundhill2021_Article_RNASequencingAndFunctionalStud.pdf
https://eprints.whiterose.ac.uk/177209/1/Roundhill2021_Article_RNASequencingAndFunctionalStud.pdf
Publikováno v:
Cancer Letters. 453:142-157
Patients with osteosarcoma (OST) frequently relapse with drug resistant disease, consistent with the hypothesis that tumours contain a cancer stem-like cell (CSCs) population that survives chemotherapy to re-populate the tumour at local or metastatic
Autor:
Elizabeth A. Roundhill, Lee Jeys, Michael Parry, Kenneth S. Rankin, Richard Foster, Jacquelyn Bond, Susan Burchill
Publikováno v:
Cancer Research. 82:1847-1847
Since Ewing sarcoma (ES) is a stem cell-like cancer1, improved outcome for some patients will be realised when treatments to eradicate ES stem-like cells (ES-CSCs) are evaluated in clinical trials. Therefore, we have identified small molecules that k
Publikováno v:
Cancer Research. 82:2015-2015
The poor survival rates and limited treatment options for patients with relapsed/metastatic Ewing sarcoma (ES) highlights the need for more personalized targeted therapeutic approaches. In this project, we have investigated the prognostic potential o
Publikováno v:
The FASEB Journal. 30:1712-1723
Overexpression of plasma membrane multidrug resistance-associated protein 1 (MRP-1) in Ewing's sarcoma (ES) predicts poor outcome. MRP-1 is also expressed in mitochondria, and we have examined the submitochondrial localization of MRP-1 and investigat