Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elizabeth A. Manrao"'
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25723 (2011)
Nanopore sequencing has the potential to become a fast and low-cost DNA sequencing platform. An ionic current passing through a small pore would directly map the sequence of single stranded DNA (ssDNA) driven through the constriction. The pore protei
Externí odkaz:
https://doaj.org/article/dd370ea14da343c69a6dccddfc3aa59e
Autor:
Elizabeth A. Manrao, Matthew K Hopper, Andrew H. Laszlo, Michael Niederweis, Kyle W. Langford, Ian M. Derrington, Jens H. Gundlach, Mikhail Pavlenok, Nathaniel Gillgren
Publikováno v:
Nature Biotechnology. 30:349-353
Nanopore technologies are being developed for fast and direct sequencing of single DNA molecules through detection of ionic current modulations as DNA passes through a pore’s constriction1,2. Here we demonstrate the ability to resolve changes in cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff89ca864b42a0ce432854ead8296a21
https://doi.org/10.1038/nbt.2171
https://doi.org/10.1038/nbt.2171
Autor:
Jay Strader, Jeff A. Valenti, Mark Ammons, Abby Fuller, Dante Minniti, Steve Vogt, Greg Henry, K. L. Tah, Bun'ei Sato, John Asher Johnson, Geoff Marcy, Chris McCarthy, Paul Butler, Sarah J. Robinson, Debra A. Fischer, Jason T. Wright, Elizabeth A. Manrao, Shigeru Ida, Peter Driscoll, Melesio Muñoz, Greg Spear, Eri Toyota, Greg Laughlin, Teresa Johnson
Publikováno v:
The Astrophysical Journal. 620:481-486
The N2K ("next 2000") consortium is carrying out a distributed observing campaign with the Keck, Magellan, and Subaru telescopes, as well as the automatic photometric telescopes of Fairborn Observatory, in order to search for short-period gas giant p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b617fffc8119f1e13142bf60e4a03f
https://doi.org/10.1086/426810
https://doi.org/10.1086/426810
Autor:
Dwayne Dunaway, Ken Chen, Joseph M. Beechem, Christopher P. Vellano, Elizabeth A. Manrao, Christina Bailey, Leroy Hood, Gavin Meredith, Chung-Ying Huang, Gokhan Demirkan, Jinho Lee, Gordon B. Mills, Sarah Warren, P. Martin Ross, Yong Zhou, Lin-ya Tang, Gloria L. Fawcett, Qian Mei, Karina Eterovic, Ping Song, Nathan Elliott, Gary K. Geiss, Tae-Beom Kim, Dae Kim, Chris Lausted
Publikováno v:
Cancer Research. 77:2441-2441
Introduction: Development of improved cancer diagnostics and therapeutics requires detailed understanding of the genomic, transcriptomic, and proteomic profiles in the tumor microenvironment. Current technologies can excel at measuring a single analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f61972146137798e4c72cd3cbda0bf1b
https://doi.org/10.1158/1538-7445.am2017-2441
https://doi.org/10.1158/1538-7445.am2017-2441
Publikováno v:
Biophysical Journal. 104(2)
Nanopore DNA sequencing is a single molecule sequencing method in which DNA is pulled through a nanometer-sized pore, while the nucleotides modulate an ionic current. We use a protein pore based on Mycobacterium smegmatis porin A (MspA) that we devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7c034d77bca6cfc0f02a7ddbce560f
Publikováno v:
Biophysical Journal. 104(2)
Epigenetic modifications of cytosines, such as 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in CpG sites of DNA, are both, inheritable and influenced by the environment. These nucleotide modifications have been shown to be important in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a168ca59e8b9e2dc75d6aa0dcfa458cf
Autor:
Jens H. Gundlach, Elizabeth A. Manrao, Matthew T. Noakes, Joshua J. Bartlett, Benjamin I. Tickman, Jackie Blum, Henry Brinkerhoff, Kyle W. Langford, Ian M. Derrington, Andrew H. Laszlo
Publikováno v:
Biophysical Journal. 110:404a
Nanopore sequencing is a promising next-generation technology that is being enabled by the biological nanopore MspA. In this sequencing technique, current is driven through the ∼1 nm constriction of MspA. Single stranded DNA molecules are first dra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0da4c420fbf370411877b8a4cc87722
https://doi.org/10.1016/j.bpj.2015.11.2180
https://doi.org/10.1016/j.bpj.2015.11.2180
Autor:
Jens H. Gundlach, Andrew H. Laszlo, Jacquelyn E. Blum, Kyle W. Langford, Elizabeth A. Manrao, Ian M. Derrington, Henry Brinkerhoff
Publikováno v:
Biophysical Journal. 106:632a-633a
We use an engineered mutant of the protein nanopore Mycobacteria smegmatis porin A (MspA) to examine single stranded DNA. The ssDNA is either held stationary within the pore by a biotin-streptavidin anchor or is processively drawn through the pore by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7144879873f04bb2e2203b587a391654
https://doi.org/10.1016/j.bpj.2013.11.3498
https://doi.org/10.1016/j.bpj.2013.11.3498
Autor:
Ian M. Derrington, Jens H. Gundlach, Marcus D. Collins, Thomas Z. Butler, Mikhail Pavlenok, Michael Niederweis, Elizabeth A. Manrao
Nanopore sequencing has the potential to become a direct, fast, and inexpensive DNA sequencing technology. The simplest form of nanopore DNA sequencing utilizes the hypothesis that individual nucleotides of single-stranded DNA passing through a nanop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4abd700eb4c44385f7dc7ceb9cf61f
https://europepmc.org/articles/PMC2941267/
https://europepmc.org/articles/PMC2941267/
Autor:
Elizabeth A. Manrao, Mikhail Pavlenok, Jens H. Gundlach, Michael Niederweis, Kyle W. Langford, Marcus D. Collins, Ian M. Derrington
Publikováno v:
Biophysical Journal. 98(3)
Biological nanopores are currently being investigated as a fast, low cost DNA sequencing platform. Single stranded DNA (ssDNA) is electrophoretically driven through a protein pore as the ionic current through the constriction is measured. The porin M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3526042d17bf7c0b05b85cb56449cfb