Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Elizabeth A. Leadbetter"'
Autor:
Thomas Hägglöf, Raksha Parthasarathy, Nathaniel Liendo, Elizabeth A. Dudley, Elizabeth A. Leadbetter
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors. Mutations in the scaffolding domain
Externí odkaz:
https://doaj.org/article/6217533d98db42d0ad868a273dc2c06b
Autor:
Raksha Parthasarathy, Thomas Hägglöf, Jason T. Hadley, Alexandra McLennan, Aiden Mattke, Elizabeth A. Dudley, Abigail Kumagai, Lily Q. Dong, Elizabeth A. Leadbetter
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mutations in the scaffolding domain of Receptor Interacting Protein kinases (RIP) underlie the recently described human autoimmune syndrome, CRIA, characterized by lymphadenopathy, splenomegaly, and autoantibody production. While disease mechanisms f
Externí odkaz:
https://doaj.org/article/db4f48a3c5e94c50b7153271a0c76fc0
Autor:
Yajun Shou, Ekaterina Koroleva, Cody M. Spencer, Sergey A. Shein, Anna A. Korchagina, Kizil A. Yusoof, Raksha Parthasarathy, Elizabeth A. Leadbetter, Armen N. Akopian, Amanda R. Muñoz, Alexei V. Tumanov
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Lymphotoxin beta receptor (LTβR) is a promising therapeutic target in autoimmune and infectious diseases as well as cancer. Mice with genetic inactivation of LTβR display multiple defects in development and organization of lymphoid organs, mucosal
Externí odkaz:
https://doaj.org/article/c223dc1cf02846ff9d4522e84a2b6a2b
Autor:
Sergey A. Shein, Anna A. Korchagina, Alexei V. Tumanov, Raksha Parthasarathy, Elizabeth A. Leadbetter, Kizil A Yusoof, Armen N. Akopian, Cody M. Spencer, Ekaterina P. Koroleva, Yajun Shou, Amanda R. Muñoz
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Lymphotoxin beta receptor (LTβR) is a promising therapeutic target in autoimmune and infectious diseases as well as cancer. Mice with genetic inactivation of LTβR display multiple defects in development and organization of lymphoid organs, mucosal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa4deaf24021ce67cd24d715f2d1f40
https://doi.org/10.3389/fimmu.2021.712632
https://doi.org/10.3389/fimmu.2021.712632
Autor:
Jr-Shiuan Lin, Elizabeth A. Leadbetter, K. Mohrs, Frank M. Szaba, Lawrence W. Kummer, Markus Mohrs
Publikováno v:
Mucosal immunology
Epidemiological data and animal studies suggest that helminth infection exerts potent immunomodulatory effects that dampen host immunity against unrelated pathogens. Despite this notion, we unexpectedly discovered that prior helminth infection result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bc090f089baa231020ef9a4eefafdf
https://doi.org/10.1038/s41385-018-0100-x
https://doi.org/10.1038/s41385-018-0100-x
Autor:
Thomas Hägglöf, Carlo Vanz, Abigail Kumagai, Elizabeth Dudley, Vanessa Ortega, McKenzie Siller, Raksha Parthasarathy, Josh Keegan, Abigail Koenigs, Travis Shute, Elizabeth A. Leadbetter
Publikováno v:
Cell Metabolism. 34:1121-1136.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3f4e73ad6a9a9c54e3697c1efaa908f
https://doi.org/10.1016/j.cmet.2022.07.002
https://doi.org/10.1016/j.cmet.2022.07.002
Publikováno v:
Immunol Rev
Invariant natural killer T (iNKT) cells mediate rapid immune responses which bridge the gap between innate and adaptive responses to pathogens while also providing key regulation to maintain immune homeostasis. Both types of important iNKT immune res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505c97f8ed1947bc4a04f19c524937b7
https://europepmc.org/articles/PMC8485762/
https://europepmc.org/articles/PMC8485762/
Publikováno v:
The Journal of Immunology. 208:160.09-160.09
Immune cells are increasingly appreciated to play a role in inflammation in adipose and hepatic tissue during obesity and may contribute to the development of non-alcoholic fatty liver disease (NAFLD). Both invariant Natural Killer T (iNKT) cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a936b7d58f30552f6691839d05251bfe
https://doi.org/10.4049/jimmunol.208.supp.160.09
https://doi.org/10.4049/jimmunol.208.supp.160.09
Publikováno v:
The Journal of Immunology. 208:122.13-122.13
Invariant natural killer T cells (iNKT) have a well-documented role in direct and indirect killing of tumor cells through their release of proinflammatory cytokines and cytotoxic compounds. To improve outcomes in poorly immunogenic cancers while avoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb8fb631a50bd1c6b4b70d6767ef27a
https://doi.org/10.4049/jimmunol.208.supp.122.13
https://doi.org/10.4049/jimmunol.208.supp.122.13
Autor:
Mitchell Laughlin, Amanda Weyers, Elizabeth Dudley, Adriana Serrata, Elizabeth A. Leadbetter, Devon A. Shipp, Rachel Fromme, Jennifer Yates, Briana Hauff Salas, Robert J. Linhardt, Travis Shute, Jianjun Miao, Chloe Mesa, Brandy Vincent, Olivia Z. Durham, Eyal Amiel, Paula A. Lanthier, Noran Alam, Emilie E. Vomhof-DeKrey, Daniel Angel, Kelly L. Nash, Katya Mohrs
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 206(8)
CD4+ T cells enable the critical B cell humoral immune protection afforded by most effective vaccines. We and others have recently identified an alternative source of help for B cells in mice, invariant NK T (iNKT) cells. iNKT cells are innate glycol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063512a4a50d32540e90f353ad46386d
https://pubmed.ncbi.nlm.nih.gov/33811104
https://pubmed.ncbi.nlm.nih.gov/33811104