Frequency determination of breast tumor-reactive CD4 and CD8 T cells in humans: unveiling the antitumor immune response

Autor: Mariana Pereira Pinho, Thiago Andrade Patente, Elizabeth Alexandra Flatow, Federica Sallusto, José Alexandre Marzagão Barbuto

Publikováno v: OncoImmunology, Vol 8, Iss 8 (2019)

As cancer immunotherapy gains importance, the determination of a patient’s ability to react to his/her tumor is unquestionably relevant. Though the presence of T cells that recognize specific tumor antigens is well established, the total frequency

Externí odkaz: https://doaj.org/article/0dacdb1f02834a77916bffc981aedd11

Abstract B80: Frequency of tumor-reactive T cells in the blood of breast cancer patients and healthy donors

Autor: Thiago A. Patente, Elizabeth Alexandra Flatow, Mariana Pereira Pinho, José Alexandre Marzagão Barbuto

Publikováno v: Cancer Immunology Research. 8:B80-B80

As cancer immunotherapy gains importance, the determination of a patient’s ability to react to his/her tumor is unquestionable. Though the presence of T cells that recognize specific tumor antigens is well established, the total frequency of tumor-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a56a8719b0d090beb26c31b4346d0ad
https://doi.org/10.1158/2326-6074.tumimm18-b80

Hypometabolism and hypothermia in the rat model of endotoxic shock: independence of circulatory hypoxia

Autor: Elizabeth Alexandra Flatow, Kevin Lewis, Alexandre A. Steiner, Joshua J. Corrigan, Monique T. Fonseca

Publikováno v: The Journal of Physiology. 592:3901-3916

Key points The hypometabolic, hypothermic response that often replaces fever in endotoxic shock might be consequential to hypoxia, but the available evidence is circumstantial. Here, this hypothesis was tested in an unprecedented experimental prepara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d939d8fa8adf2b00830f4e3198e115a
https://doi.org/10.1113/jphysiol.2014.277277

The role of leptin on hypothermia during endotoxic shock

Autor: Elizabeth Alexandra Flatow

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

A hipotermia é uma das respostas presentes em casos mais graves de sepse. Em modelos animais, essa hipotermia parece regulada e pode ter valor adaptativo quando a febre torna-se uma ameaça ao hospedeiro. A leptina é um hormônio produzido pelo tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5546ddec9af58d26b03efc050c7c01f7

Respiratory gas exchange as a new aid to monitor acidosis in endotoxemic rats: relationship to metabolic fuel substrates and thermometabolic responses

Autor: Elizabeth Alexandra Flatow, Monique T. Fonseca, Evilin Naname Komegae, Alexandre A. Steiner, Camila F. Brito

Publikováno v: Physiological Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

This study introduces the respiratory exchange ratio (RER; the ratio of whole‐body CO 2 production to O 2 consumption) as an aid to monitor metabolic acidosis during the early phase of endotoxic shock in unanesthetized, freely moving rats. Two sero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df39216adf89f6a12599cdd647c50d2
https://doi.org/10.14814/phy2.13100