Výsledky vyhledávání - "Elizabeth A. Faidley"

Akademický článek

Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction

Autor: Lori N. Eidson, Qingzeng Gao, Hongyan Qu, Daniel S. Kikuchi, Ana Carolina P. Campos, Elizabeth A. Faidley, Yu-Yo Sun, Chia-Yi Kuan, Rosana L. Pagano, Bernard Lassègue, Malú G. Tansey, Kathy K. Griendling, Marina S. Hernandes

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Stroke is a multiphasic process involving a direct ischemic brain injury which is then exacerbated by the influx of immune cells into the brain tissue. Activation of brain endothelial cells leads to the expression of adhesion molecules such

Externí odkaz: https://doaj.org/article/ca6d527a5c274240a41e6c574dee592d

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Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome

Autor: Guogang Zhang, Bernard Lassègue, Marina S. Hernandes, Kathy K. Griendling, Steven J. Forrester, Elizabeth A. Faidley, Derick Okwan-Duodu, Ana Carolina Pinheiro Campos, Daniel S. Kikuchi, Qian Xu, Ruxana T. Sadikot

Publikováno v: Clin Sci (Lond)

Acute respiratory distress syndrome (ARDS) in a deadly disease that can be brought on by endotoxins such as lipopolysaccharide (LPS). ARDS is characterized by vascular permeability, a severe inflammatory response, lung leukocyte infiltration, and res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42793e057c26186c0cd21038e05a50a
https://doi.org/10.1042/cs20180944

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Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction

Autor: Yu-Yo Sun, Marina S. Hernandes, Hongyan Qu, Ana Carolina Pinheiro Campos, Kathy K. Griendling, Rosana L. Pagano, Daniel S. Kikuchi, Qingzeng Gao, Malú G. Tansey, Lori N. Eidson, Chia-Yi Kuan, Bernard Lassègue, Elizabeth A. Faidley

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Stroke is a multiphasic process involving a direct ischemic brain injury which is then exacerbated by the influx of immune cells into the brain tissue. Activation of brain endothelial cells leads to the expression of adhesion molecules such vascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac904218bbddc1918a88a64c15c651b
https://pubmed.ncbi.nlm.nih.gov/33692398

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Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer

Autor: Bernard Lassègue, Samantha M. Yeligar, Alejandra San Martin, Victor M. Darley-Usmar, Gloria A. Benavides, Holly C. Williams, Elizabeth A. Faidley, Felipe Paredes, Fernanda Sanhueza-Olivares, Kely L. Sheldon, Kathy K. Griendling, Gloria Torres

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance The present work establishes that the addition of the prosthetic group lipoic acid to catabolic enzymes is a dynamically regulated posttranslational modification that increases metabolic plasticity under hypoxia and in cancer cells. We s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aa2b542f8361b8af5c0210b0893565
https://doi.org/10.1073/pnas.1720693115

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Polymerase-δ-interacting protein 2 activates the RhoGEF epithelial cell transforming sequence 2 in vascular smooth muscle cells

Autor: Michelle Z. Tsai, Steven J. Forrester, Daniel Seicho Kikuchi, Lauren P. Huff, Kathy K. Griendling, Elizabeth A. Faidley, Bernard Lassègue

Publikováno v: Am J Physiol Cell Physiol

Polymerase-δ-interacting protein 2 (Poldip2) controls a wide variety of cellular functions and vascular pathologies. To mediate these effects, Poldip2 interacts with numerous proteins and generates reactive oxygen species via the enzyme NADPH oxidas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1ca1c712be747406cd124827b1a7fe
https://europepmc.org/articles/PMC6580162/

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NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion

Autor: Lula Hilenski, Kathy K. Griendling, Bernard Lassègue, Leslie B. Poole, Ulrich P. Jorde, Qian Xu, Anna Dikalova, Guogang Zhang, Sasa Vukelic, Elizabeth A. Faidley, Bonnie Seidel-Rogol

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 38(10)

Objective— Actin cytoskeleton assembly and organization, as a result of focal adhesion (FA) formation during cell adhesion, are dependent on reactive oxygen species and the cellular redox environment. Poldip2 (polymerase δ-interacting protein 2),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b050289f1cdeceda938b659b0a08eaf3
https://pubmed.ncbi.nlm.nih.gov/30354218

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Reply to Bailey et al.: New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway

Autor: A. San Martin, Gloria A. Benavides, Kathy K. Griendling, Samantha M. Yeligar, Bernard Lassègue, Hugh Williams, Victor M. Darley-Usmar, Felipe Paredes, Elizabeth A. Faidley

Publikováno v: Proceedings of the National Academy of Sciences. 115

We appreciate Bailey et al.’s (1) interest in our publication (2), in which we define a role for polymerase-δ interacting protein 2 (Poldip2) in controlling a salvage pathway of lipoylation. Our study builds on a substantial body of evidence, indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35363d7f70a9bb3217e3d02c1328be1f
https://doi.org/10.1073/pnas.1807968115

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A minimal dose of electrically induced muscle activity regulates distinct gene signaling pathways in humans with spinal cord injury

Autor: Manish Suneja, Elizabeth A. Faidley, Michael A. Petrie, Richard K. Shields

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 12, p e115791 (2014)

Paralysis after a spinal cord injury (SCI) induces physiological adaptations that compromise the musculoskeletal and metabolic systems. Unlike non-SCI individuals, people with spinal cord injury experience minimal muscle activity which compromises op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626703e806e5df617453dcbdbe1871fc
https://pubmed.ncbi.nlm.nih.gov/25531450

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Low force contractions induce fatigue consistent with muscle mRNA expression in people with spinal cord injury

Autor: Manish Suneja, Richard K. Shields, Michael A. Petrie, Elizabeth A. Faidley

Publikováno v: Physiological Reports

Spinal cord injury (SCI) is associated with muscle atrophy, transformation of muscle fibers to a fast fatigable phenotype, metabolic inflexibility (diabetes), and neurogenic osteoporosis. Electrical stimulation of paralyzed muscle may mitigate muscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7a3336adb14604f09d0c97c1fd00bf
http://europepmc.org/articles/PMC3966256

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Choriocapillaris vascular dropout related to density of drusen in human eyes with early age-related macular degeneration

Autor: Elizabeth A. Faidley, Micaela N. Johnson, Robert F. Mullins, Jian Huang, Jessica M. Skeie

Publikováno v: Investigative ophthalmologyvisual science. 52(3)

Age-related macular degeneration (AMD) is a common, potentially blinding disorder affecting the aged. In advanced stages of the disease, vision in the macular region can be severely compromised by either atrophic changes in the retinal pigment epithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d9efcdbbf19fc9631680eb70198f58
https://pubmed.ncbi.nlm.nih.gov/21398287

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