Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elizabeth A. Daley"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT The understanding of the antimicrobial activities of non-antibiotic pharmaceuticals is evolving, with growing interest in their implications for antimicrobial resistance (AMR) in gut bacteria. Quetiapine, a frequently prescribed second-gener
Externí odkaz:
https://doaj.org/article/201ec77ab2c34236abe049799d15f6bd
Autor:
Amanda M. Gleixner, Brandie Morris Verdone, Charlton G. Otte, Eric N. Anderson, Nandini Ramesh, Olivia R. Shapiro, Jenna R. Gale, Jocelyn C. Mauna, Jacob R. Mann, Katie E. Copley, Elizabeth L. Daley, Juan A. Ortega, Maria Elena Cicardi, Evangelos Kiskinis, Julia Kofler, Udai B. Pandey, Davide Trotti, Christopher J. Donnelly
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
ALS and FTLD are both characterized by insoluble cytoplasmic depositions of TDP43. Here the authors show that the nucleopore protein NUP62 is mislocalized in C9orf72 and sporadic ALS/FTLD and propose that it interacts with TDP-43 to promote its insol
Externí odkaz:
https://doaj.org/article/04c38fed278645e2a4a1f52a4ea229f4
Autor:
Nandini Ramesh, Elizabeth L. Daley, Amanda M. Gleixner, Jacob R. Mann, Sukhleen Kour, Darilang Mawrie, Eric N. Anderson, Julia Kofler, Christopher J. Donnelly, Evangelos Kiskinis, Udai Bhan Pandey
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract The most common genetic cause of amyotrophic lateral sclerosis (ALS) is a GGGGCC (G4C2) hexanucleotide repeat expansions in first intron of the C9orf72 gene. The accumulation of repetitive RNA sequences can mediate toxicity potentially throu
Externí odkaz:
https://doaj.org/article/1cf66c3ab0a940b798d08606fc8852ef
Autor:
Juan A. Ortega, Ivan R. Sasselli, Marco Boccitto, Andrew C. Fleming, Tyler R. Fortuna, Yichen Li, Kohei Sato, Tristan D. Clemons, Elizabeth L. Daley, Thao P. Nguyen, Eric N. Anderson, Justin K. Ichida, Udai B. Pandey, Sandra Wolin, Samuel I. Stupp, Evangelos Kiskinis
Amyotrophic lateral sclerosis and frontotemporal dementia patients with a hexanucleotide repeat expansion inC9ORF72(C9-HRE) accumulate poly-GR and poly-PR aggregates. The pathogenicity of these arginine-rich dipeptide repeats (R-DPRs) is thought to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e27b2598f16fa7130cbc75eb630d06c
https://doi.org/10.1101/2022.12.30.522259
https://doi.org/10.1101/2022.12.30.522259
Autor:
Brandie Morris Verdone, Jacob R. Mann, Nandini Ramesh, Charlton Otte, Amanda M. Gleixner, Christopher J. Donnelly, Udai Bhan Pandey, Juan A. Ortega, Julia Kofler, Davide Trotti, Evangelos Kiskinis, Maria Elena Cicardi, Elizabeth L. Daley, Jenna Gale, Katie E. Copley, Jocelyn C. Mauna
Amyotrophic lateral sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD) share clinical, neuropathological, and genetic features. This includes common genetic disease-causing mutations such as the expanded G4C2 repeat in the C9orf72 gene (C9-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac407f7f82855b5fa923fc2e50fe1450
https://doi.org/10.21203/rs.3.rs-144654/v1
https://doi.org/10.21203/rs.3.rs-144654/v1
Autor:
Amanda M. Gleixner, Brandie Morris Verdone, Charlton G. Otte, Eric N. Anderson, Nandini Ramesh, Olivia R. Shapiro, Jenna R. Gale, Jocelyn C. Mauna, Jacob R. Mann, Katie E. Copley, Elizabeth L. Daley, Juan A. Ortega, Maria Elena Cicardi, Evangelos Kiskinis, Julia Kofler, Udai B. Pandey, Davide Trotti, Christopher J. Donnelly
Publikováno v:
Nature communications. 13(1)
A G4C2 hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of ALS and FTLD (C9-ALS/FTLD) with cytoplasmic TDP-43 inclusions observed in regions of neurodegeneration. The accumulation of repetitive RNAs and dipeptide r
Autor:
Elizabeth M. Daley, Holly Willis
Publikováno v:
Educating the Whole Child for the Whole World ISBN: 9780814786550
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46da0cc15663e53a15dc1fc8bdf1352a
https://doi.org/10.18574/nyu/9780814741405.003.0008
https://doi.org/10.18574/nyu/9780814741405.003.0008
Autor:
Juan A. Ortega, Christopher J. Donnelly, Marisa Samani, Haley S. Smith, Elizabeth L. Daley, Evangelos Kiskinis, Sukhleen Kour, Elizabeth A. H. Hall, Jeffrey N. Savas, Yung Hsu Tsai, Teepu Siddique, Tania F. Gendron, Udai Bhan Pandey, Y. Taylan Esengul, Liana Tellez
SUMMARYThe most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a hexanucleotide repeat expansion in C9orf72 (C9-HRE). While RNA and dipeptide repeats produced by the C9-HRE disrupt nucleocytoplasmic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e944948dbf3037afb7b2ef895da761e
https://doi.org/10.1101/677419
https://doi.org/10.1101/677419
Autor:
Divya Joshi, Kyriakos Dalamagkas, Elizabeth L. Daley, Evangelos Kiskinis, Rogan A. Grant, John D. Finan, Audrey S. Leung, Colin K. Franz
Publikováno v:
J Neurophysiol
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons, which manifests clinically as progressive weakness. Although several epidemiological studies have found an association betw
Autor:
Tania F. Gendron, Liana Tellez, Elizabeth L. Daley, Elizabeth A. H. Hall, Jeffrey N. Savas, Sukhleen Kour, Udai Bhan Pandey, Y. Taylan Esengul, Marisa Samani, Yung Hsu Tsai, Evangelos Kiskinis, Haley S. Smith, Christopher J. Donnelly, Teepu Siddique, Juan A. Ortega
Publikováno v:
Neuron. 106:90-107.e13
Summary The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a hexanucleotide repeat expansion in C9orf72 (C9-HRE). While RNA and dipeptide repeats produced by C9-HRE disrupt nucleocytoplasmic tran