Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Elizabeth A. Creasey"'
Autor:
Jinjin Xu, Lingjia Kong, Blayne A. Oliver, Bihua Li, Elizabeth A. Creasey, Gaelen Guzman, Monica Schenone, Kimberly L. Carey, Steven A. Carr, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112708- (2023)
Summary: Autophagy is an essential cellular process that is deeply integrated with innate immune signaling; however, studies that examine the impact of autophagic modulation in the context of inflammatory conditions are lacking. Here, using mice with
Externí odkaz:
https://doaj.org/article/f9611e7977944a31a27cb9364c77c01a
Autor:
Won Young Choi, Seongok Kim, Philipp Aurass, Wenwen Huo, Elizabeth A. Creasey, Marc Edwards, Martin Lowe, Ralph R. Isberg
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109894- (2021)
Summary: Legionella pneumophila grows intracellularly within a replication vacuole via action of Icm/Dot-secreted proteins. One such protein, SdhA, maintains the integrity of the vacuolar membrane, thereby preventing cytoplasmic degradation of bacter
Externí odkaz:
https://doaj.org/article/68d2299132fb4f0b9cf551af7808893d
Autor:
Robert G. Mealer, Sarah E. Williams, Maxence Noel, Bo Yang, Alexandria K. D’Souza, Toru Nakata, Daniel B. Graham, Elizabeth A. Creasey, Murat Cetinbas, Ruslan I. Sadreyev, Edward M. Scolnick, Christina M. Woo, Jordan W. Smoller, Ramnik J. Xavier, Richard D. Cummings
Publikováno v:
Mol Psychiatry
A missense mutation (A391T) in SLC39A8 is strongly associated with schizophrenia in genomic studies, though the molecular connection to the brain is unknown. Human carriers of A391T have reduced serum manganese, altered plasma glycosylation, and brai
Autor:
Lingjia Kong, Vladislav Pokatayev, Ariel Lefkovith, Grace T. Carter, Elizabeth A. Creasey, Chirag Krishna, Sathish Subramanian, Bharati Kochar, Orr Ashenberg, Helena Lau, Ashwin N. Ananthakrishnan, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Publikováno v:
Immunity. 56:444-458.e5
Autor:
Motohiko Kadoki, Daniel B. Graham, Mark J. Daly, Ariel Lefkovith, Helen Lin, Toru Nakata, Martin K. Selig, Elizabeth A. Creasey, Junmei Yao, Ramnik J. Xavier
Publikováno v:
Proceedings of the National Academy of Sciences. 117:28930-28938
Common genetic variants interact with environmental factors to impact risk of heritable diseases. A notable example of this is a single-nucleotide variant in the Solute Carrier Family 39 Member 8 (SLC39A8) gene encoding the missense variant A391T, wh
Autor:
Martin Lowe, Philipp Aurass, Marc Edwards, Wenwen Huo, Seongok Kim, Won Young Choi, Ralph R. Isberg, Elizabeth A. Creasey
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109894-(2021)
Choi, W Y, Kim, S, Aurass, P, Huo, W, Creasey, E A, Edwards, M, Lowe, M & Isberg, R R 2021, ' SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase ', Cell Reports, vol. 37, no. 5, 109894, pp. 109894 . https://doi.org/10.1016/j.celrep.2021.109894
Cell reports
Choi, W Y, Kim, S, Aurass, P, Huo, W, Creasey, E A, Edwards, M, Lowe, M & Isberg, R R 2021, ' SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase ', Cell Reports, vol. 37, no. 5, 109894, pp. 109894 . https://doi.org/10.1016/j.celrep.2021.109894
Cell reports
SUMMARY Legionella pneumophila grows intracellularly within a replication vacuole via action of Icm/Dot-secreted proteins. One such protein, SdhA, maintains the integrity of the vacuolar membrane, thereby preventing cytoplasmic degradation of bacteri
Autor:
Xiangjun Chen, Alok Jaiswal, Zachary Costliow, Paula Herbst, Elizabeth A. Creasey, Noriko Oshiro-Rapley, Mark J. Daly, Kimberly L. Carey, Daniel B. Graham, Ramnik J. Xavier
Publikováno v:
Nat Immunol
Extracellular acidification occurs in inflamed tissue and the tumor microenvironment; however, a systematic study on how pH sensing contributes to tissue homeostasis is lacking. Here, we examine cell type-specific roles of the pH sensor GPR65 and its
Autor:
Daniel B. Graham, Maxence Noel, Alexandria K. D’Souza, Sarah E. Williams, Richard D. Cummings, Elizabeth A. Creasey, Robert G. Mealer, Ruslan I. Sadreyev, Murat Cetinbas, Toru Nakata, Edward M. Scolnick, Bo Yang, Jordan W. Smoller, Christina M. Woo, Ramnik J. Xavier
A missense mutation (A391T) in the manganese transporter SLC39A8 is strongly associated with schizophrenia in genomic studies, though the molecular connection to the brain remains hypothetical. Human carriers of A391T have reduced serum manganese, al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba30ba7db651dfa9ac4d6d2996bd76bf
https://doi.org/10.1101/2020.12.22.424076
https://doi.org/10.1101/2020.12.22.424076
Autor:
Toru, Nakata, Elizabeth A, Creasey, Motohiko, Kadoki, Helen, Lin, Martin K, Selig, Junmei, Yao, Ariel, Lefkovith, Mark J, Daly, Daniel B, Graham, Ramnik J, Xavier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SLC39A8 A391T exhibits remarkable pleiotropic effects on multiple conditions, including cardiovascular diseases, Parkinson’s disease, and Crohn’s disease. However, how this single coding variant impacts such a wide range of pathologi
Autor:
Steven A. Carr, Elizabeth A. Creasey, A. Nicole Desch, Atul K. Bhan, Zhifang Cao, Vishnu Mohanan, Gaelen Guzman, Chloé Lévesque, Junmei Yao, Angela C. Boroughs, Monica Schenone, Ramnik J. Xavier, Toru Nakata, John D. Rioux, Guy Charron, Kara G. Lassen, Gabrielle Boucher, Hans Christian Reinecker, Mark J. Daly
Publikováno v:
Science. 359:1161-1166
Overcoming a barrier to IBD Inflammatory bowel disease (IBD) is a group of disorders linked to inflammation of the gastrointestinal tract. Colitis is a type of IBD that affects the inner lining of the colon and has been linked to a gene known as C1or