Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Autor: Elizabeth Spangenberg, Paul L. Severson, Lindsay A. Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A. Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y. Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L. West, Kim N. Green

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)

Genetics implicate microglia in Alzheimer’s disease pathogenesis, but their roles remain unclear. Here, the authors find that microglial depletion in a mouse model of Alzheimer’s disease impairs plaque formation and that Aβ-induced changes in ne

Externí odkaz: https://doaj.org/article/ab83dec7482d44a28b96b168ea75f0ff

Neoadjuvant immunotherapy across cancers: meeting report from the Immunotherapy Bridge—December 1st–2nd, 2021

Autor: Elizabeth M. Burton, Rodabe N. Amaria, Tina Cascone, Myriam Chalabi, Neil D. Gross, Elizabeth A. Mittendorf, Richard A. Scolyer, Padmanee Sharma, Paolo A. Ascierto

Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-11 (2022)

Abstract After the success of immunotherapy in the treatment of advanced metastatic cancer, further evaluation in earlier settings, including high-risk, surgically-resectable disease is underway. Potential benefits of a neoadjuvant immunotherapeutic

Externí odkaz: https://doaj.org/article/cfb90c8c178541e79522621d06de02ab

Clinical Characteristics and Cause of Death Among Hospitalized Decedents With Cancer and COVID-19

Autor: Dereddi Raja Reddy, John A. Cuenca, Joshua Botdorf, Mayoora Muthu, Ankit Hanmandlu, Robert Wegner, John Crommett, Cristina Gutierrez, Nisha Rathi, Bilja Sajith, Mark Knafl, Hussein A. Abbas, Scott E. Woodman, Joseph L. Nates, Ashley Aaroe, Thomas A. Aloia, Lee Andrews, Kiran K. Badami, Janna A. Baganz, Pratibha Bajwa, Lori R. Baker, Gregory R. Barbosa, Hannah C. Beird, Matt Bourgeois, Kristy Brock, Elizabeth M. Burton, Juan Cata, Caroline Chung, Michael Cutherell, Pierre B. Cyr, Bouthaina Dabaja, Hiba Dagher, Kevin M. Daniels, Mary Domask, Giulio Draetta, Sarah Fisher, Katy Elizabeth French, Andrew Futreal, Maria Gaeta, Christopher Gibbons, Myrna Godoy, Drew Goldstein, Jillian Gunther, Cristhiam Hernandez, Kate Hutcheson, David Jaffray, Jeff Jin, Teny Matthew John, Trey Kell, Anai Kothari, Rayson C. Kwan, J. Jack Lee, Yue Liao, Jennifer Litton, Alex Liu, Kevin W. McEnery, Mary McGuire, Tego Musunuru, Craig S. Owen, Priyadharshini Padmakumar, Melody Page, Nicholas Palaskas, Jay J. Patel, Sabitha Prabhakaran, Vinod Ravi, Ludivine Russell, Paul A. Scheet, Stephanie Schmidt, Kenna R. Shaw, Sanjay Shete, Daniel P. Shoenthal, Lessley J. Stoltenberg, Ishwaria Subbiah, Chuck Suitor, Hussein Tawbi, Phillip Thompson, Anastasia Turin, Samir Unni, Benju Vicknamparampil, Max C. Weber, John Weinstein, Zoe Williams, Mark C. Wozny, Carol Wu, Jia Wu, James C. Yao, Chingyi Young, Emily Yu, Steven Zatorski

Publikováno v: Mayo Clinic Proceedings. 98:451-457

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0e4285ed56e25e2fcce40cf942510c3
https://doi.org/10.1016/j.mayocp.2022.12.008

Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma

Autor: Alexander C J, van Akkooi, Tina J, Hieken, Elizabeth M, Burton, Charlotte, Ariyan, Paolo A, Ascierto, Salvatore V M A, Asero, Christian U, Blank, Matthew S, Block, Genevieve M, Boland, Corrado, Caraco, Sydney, Chng, B Scott, Davidson, Joao Pedreira, Duprat Neto, Mark B, Faries, Jeffrey E, Gershenwald, Dirk J, Grunhagen, David E, Gyorki, Dale, Han, Andrew J, Hayes, Winan J, van Houdt, Giorgos C, Karakousis, Willem M C, Klop, Georgina V, Long, Michael C, Lowe, Alexander M, Menzies, Roger, Olofsson Bagge, Thomas E, Pennington, Piotr, Rutkowski, Robyn P M, Saw, Richard A, Scolyer, Kerwin F, Shannon, Vernon K, Sondak, Hussein, Tawbi, Alessandro A E, Testori, Mike T, Tetzlaff, John F, Thompson, Jonathan S, Zager, Charlotte L, Zuur, Jennifer A, Wargo, Andrew J, Spillane, Merrick I, Ross

Publikováno v: Annals of Surgical Oncology, 29(6), 3694-3708. Springer New York

Exciting advances in melanoma systemic therapies have presented the opportunity for surgical oncologists and their multidisciplinary colleagues to test the neoadjuvant systemic treatment approach in high-risk, resectable metastatic melanomas. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e872abd5d1a96ea257aff63c3b671c
https://doi.org/10.1245/s10434-021-11236-y

Supplementary Tables 1 - 6, Figures 1 - 7 from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 'Gatekeeper' F691L Mutation with PLX3397

Autor: Neil P. Shah, Gideon Bollag, Brian L. West, Gaston Habets, Henry H. Hsu, Mai H. Le, Prabha N. Ibrahim, Wayne Spevak, Jiazhong Zhang, Bernice Matusow, Elizabeth A. Burton, Ben Powell, Heidi Carias, Garson Tsang, Rafe Shellooe, Andrew Kasarskis, Alexander Perl, Robert Sebra, Ali Bashir, Matthew Pendleton, Lauren E. Damon, Evan Massi, Ying Zhang, Elisabeth A. Lasater, Kimberly C. Lin, Chao Zhang, Catherine C. Smith

Supplementary Table 1. Crystallographic Data and Refinement statistics. Supplementary Table 2. Comparing Target Inhibition by Quizartinib and PLX3397 in Engineered Ba/F3 cells Expressing FLT3-ITD, FLT3-ITD/F691L and FLT3-ITD/D835Y. Supplementary Tabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3238bc9253c505ce861afdefa65ccf
https://doi.org/10.1158/2159-8290.22531562.v1