Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Elizabeth A. Frey"'
Autor:
Calvin K. Yip, Elizabeth A. Frey, Natalie C. J. Strynadka, José L. Puente, Wanyin Deng, Nikhil A. Thomas, B. Brett Finlay
Publikováno v:
Molecular Microbiology. 57:1762-1779
Enteropathogenic Escherichia coli (EPEC) is an intestinal attaching and effacing pathogen that utilizes a type III secretion system (T3SS) for the delivery of effectors into host cells. The chaperone CesT has been shown to bind and stabilize the type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cce9bc0845304873c24da03eaa9d896
https://doi.org/10.1111/j.1365-2958.2005.04802.x
https://doi.org/10.1111/j.1365-2958.2005.04802.x
Autor:
Natalie C. J. Strynakda, Samantha Gruenheid, Philip R. Hardwidge, Richard A. Pfuetzner, José L. Puente, Wanyin Deng, Sansan Lee, B. Brett Finlay, Yuling Li, Elizabeth A. Frey
Publikováno v:
Infection and Immunity. 73:2135-2146
Human enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC), and the mouse pathogen Citrobacter rodentium (CR) belong to the family of attaching and effacing (A/E) bacterial pathogens. They possess the locus of enterocyte effacem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bf8d755465a5b9912acb46b8d09222
https://doi.org/10.1128/iai.73.4.2135-2146.2005
https://doi.org/10.1128/iai.73.4.2135-2146.2005
Autor:
Paula I. Lario, Louise Creagh, Charles A. Haynes, Elizabeth A. Frey, Anthony T. Maurelli, Richard A. Pfuetzner, Natalie C. J. Strynadka
Publikováno v:
The EMBO Journal. 24:1111-1121
The ability to translocate virulence proteins into host cells through a type III secretion apparatus (TTSS) is a hallmark of several Gram‐negative pathogens including Shigella, Salmonella, Yersinia, Pseudomonas , and enteropathogenic Escherichia co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5589f9b267ad8c4db03bb6c932b0be
https://doi.org/10.1038/sj.emboj.7600610
https://doi.org/10.1038/sj.emboj.7600610
Autor:
Pavel Metalnikov, Nikhil A. Thomas, David L Goode, Nathaniel Francis Brown, Tony Pawson, Yuling Li, Elizabeth A. Frey, Paul O'Donnell, B. Brett Finlay, Samantha Gruenheid, Wanyin Deng, Keith Ashman, Inna Sekirov
Publikováno v:
Molecular Microbiology. 51:1233-1249
Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 uses a specialized protein translocation apparatus, the type III secretion system (TTSS), to deliver bacterial effector proteins into host cells. These effectors interfere with host cytoskeletal path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c9e95608ae53a0d4531de2125f1578
https://doi.org/10.1046/j.1365-2958.2003.03911.x
https://doi.org/10.1046/j.1365-2958.2003.03911.x
Autor:
Rodney A. Moxley, Dragan Rogan, B. Brett Finlay, Susanne Hinkley, Andrew A. Potter, Hugh G.G. Townsend, Terry J. Klopfenstein, David R. Smith, Galen E. Erickson, Sandra Klashinsky, Yuling Li, Elizabeth A. Frey
Publikováno v:
Vaccine. 22:362-369
Cattle are an important reservoir of Escherichia coli O157:H7 leading to contamination of food and water, and subsequent human disease. This pathogen colonizes its hosts by producing several proteins such as Tir and EspA that are secreted by a type I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda7a8758ebb1c38af4418d512aff991
https://doi.org/10.1016/j.vaccine.2003.08.007
https://doi.org/10.1016/j.vaccine.2003.08.007
Autor:
Michela G. Bertero, B. Brett Finlay, Sandra L. Marcus, Cyril M. Kay, Louise Creagh, Daniel Lim, Charles A. Haynes, Natalie C. J. Strynadka, Elizabeth A. Frey, Frank Sicheri, Yu Luo, Markus R. Wenk, Richard A. Pfuetzner
Publikováno v:
Nature Structural Biology. 8:1031-1036
Several Gram-negative bacterial pathogens have evolved a type III secretion system to deliver virulence effector proteins directly into eukaryotic cells, a process essential for disease. This specialized secretion process requires customized chaperon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e639afb1e77c305c68fc65f5775715ae
https://doi.org/10.1038/nsb717
https://doi.org/10.1038/nsb717
Autor:
Maia M. Cherney, Richard A. Pfuetzner, John W. Little, Mark Paetzel, Yu Luo, Natalie C. J. Strynadka, Steve Mosimann, Elizabeth A. Frey, Baek Kim
Publikováno v:
Cell. 106:585-594
LexA repressor undergoes a self-cleavage reaction. In vivo, this reaction requires an activated form of RecA, but it occurs spontaneously in vitro at high pH. Accordingly, LexA must both allow self-cleavage and yet prevent this reaction in the absenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d77a6f8c27101bfd24b47d9da92b4f
https://doi.org/10.1016/s0092-8674(01)00479-2
https://doi.org/10.1016/s0092-8674(01)00479-2
Publikováno v:
Infection and Immunity. 68:5090-5095
Vaccination has been proposed for the prevention of disease due to enterohemorrhagic Escherichia coli (EHEC), but the immune response following human infection, including the choice of potential antigens, has not been well characterized. To study thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8b9d0b1901ac7b44299336ba1f6e91
https://doi.org/10.1128/iai.68.9.5090-5095.2000
https://doi.org/10.1128/iai.68.9.5090-5095.2000
Autor:
Elizabeth A. Frey, Danika L. Goosney, Richard A. Pfuetzner, Natalie C. J. Strynadka, B. Brett Finlay, Rebekah DeVinney
Publikováno v:
Current Biology. 10:735-738
Enteropathogenic Escherichia coli (EPEC) triggers a dramatic rearrangement of the host epithelial cell actin cytoskeleton to form an attaching and effacing lesion, or pedestal. The pathogen remains attached extracellularly to the host cell through th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71163030a64d995b3b7affbd790923fc
https://doi.org/10.1016/s0960-9822(00)00543-1
https://doi.org/10.1016/s0960-9822(00)00543-1
Autor:
B. Brett Finlay, Elizabeth A. Frey
Publikováno v:
Microbial Pathogenesis. 24:101-109
We investigated the mode of bovine endothelial cell death induced by lipopolysaccharide (LPS). Inter-nucleosomal DNA fragmentation was observed indicating apoptotic cell death. Apoptosis was confirmed by examining cell morphology using confocal laser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58222d200b97f236dde60473dd75abf0
https://doi.org/10.1006/mpat.1997.0178
https://doi.org/10.1006/mpat.1997.0178