Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Elizabeth A Komives"'
Publikováno v:
eLife, Vol 11 (2022)
Argonaute (Ago) proteins play a central role in post-transcriptional gene regulation through RNA interference (RNAi). Agos bind small RNAs (sRNAs) including small interfering RNAs (siRNAs) and microRNAs (miRNAs) to form the functional core of the RNA
Externí odkaz:
https://doaj.org/article/57c22c00cddd48feb08566deaa338e49
Autor:
Tobias Kromann-Hansen, Eva Louise Lange, Ida K Lund, Gunilla Høyer-Hansen, Peter A Andreasen, Elizabeth A Komives
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192661 (2018)
The catalytic activity of trypsin-like serine proteases is in many cases regulated by conformational changes initiated by binding of physiological modulators to exosites located distantly from the active site. A trypsin-like serine protease of partic
Externí odkaz:
https://doaj.org/article/e330651c2ec4416eab304ecffe07f697
Autor:
Matthew Mealka, Nicole A. Sierra, Diego Avellaneda Matteo, Elene Albekioni, Rachel Khoury, Timothy Mai, Brittany M. Conley, Nalani J. Coleman, Kaitlyn A. Sabo, Elizabeth A. Komives, Andrey A. Bobkov, Andrew L. Cooksy, Steve Silletti, Jamie M. Schiffer, Tom Huxford, Christal D. Sohl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is understood of the mechanistic di
Externí odkaz:
https://doaj.org/article/7dd4b88185a6417cae6407ecdeef7ede
Autor:
Nicholas P Schafer, Ryan M B Hoffman, Anat Burger, Patricio O Craig, Elizabeth A Komives, Peter G Wolynes
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50635 (2012)
A general method for facilitating the interpretation of computer simulations of protein folding with minimally frustrated energy landscapes is detailed and applied to a designed ankyrin repeat protein (4ANK). In the method, groups of residues are ass
Externí odkaz:
https://doaj.org/article/ec82ee5bf64b4e8586c0007edef214e3
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 5, p e1000070 (2008)
Repeat-proteins are made up of near repetitions of 20- to 40-amino acid stretches. These polypeptides usually fold up into non-globular, elongated architectures that are stabilized by the interactions within each repeat and those between adjacent rep
Externí odkaz:
https://doaj.org/article/42799375a96d4f6ca842d7db60bab7fa
Autor:
Elizabeth A. Komives
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Thrombin is a serine protease that catalyzes a large number of different reactions including proteolytic cleave of fibrinogen to make the fibrin clot (procoagulant activity), of the protease activated receptors (for cell signaling) and of protein C g
Externí odkaz:
https://doaj.org/article/32a52ad047e74b93a0be24d7674c281f
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/c6f33251197e47a780a4655907d13cbd
Publikováno v:
Methods. 213:18-25
Autor:
Kaitlyn A. Sabo, Elene Albekioni, Danielle Caliger, Nalani J. Coleman, Ella Thornberg, Diego Avellaneda Matteo, Elizabeth A. Komives, Steve Silletti, Christal D. Sohl
Publikováno v:
Biochemistry
Human isocitrate dehydrogenase 1 (IDH1) is a highly conserved metabolic enzyme that catalyzes the interconversion of isocitrate and α-ketoglutarate. Kinetic and structural studies with IDH1 have revealed evidence of striking conformational changes t
Autor:
José Alejandro Molina, Pablo Galaz-Davison, Elizabeth A Komives, Irina Artsimovitch, César A Ramírez-Sarmiento
Publikováno v:
Nucleic Acids Research. 50:6384-6397
In every domain of life, NusG-like proteins bind to the elongating RNA polymerase (RNAP) to support processive RNA synthesis and to couple transcription to ongoing cellular processes. Structures of factor-bound transcription elongation complexes (TEC