Výsledky vyhledávání - "Elizabeth A Hinnant"

Akademický článek

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent.

Autor: Sarah A Comerford, Elizabeth A Hinnant, Yidong Chen, Robert E Hammer

Publikováno v: PLoS Genetics, Vol 19, Iss 1, p e1010595 (2023)

Defective ribosome biogenesis (RiBi) underlies a group of clinically diverse human diseases collectively known as the ribosomopathies, core manifestations of which include cytopenias and developmental abnormalities that are believed to stem primarily

Externí odkaz: https://doaj.org/article/1b21ea99c6e74ce281bd9d329146aa8d

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Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin

Autor: Dinesh Rakheja, Hima Bansal, Sarah A. Comerford, Yi Chen, Shawn Klapproth, Dolores Lopez-Terrada, Robert E. Hammer, Gail E. Tomlinson, Milton J. Finegold, Elizabeth A. Hinnant, Kathryn A. O'Donnell

Aberrant wnt/β-catenin signaling and amplification/overexpression of Myc are associated with hepatoblastoma (HB), the most prevalent type of childhood liver cancer. To address their roles in the pathogenesis of HB, we generated mice in which Myc and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a8a47dd257d334072c0eee0441ba51
https://europepmc.org/articles/PMC5053152/

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Induction of hepatocyte proliferation and death by modulation of T-Antigen expression

Autor: Sarah A. Comerford, David E. Clouthier, Robert E. Hammer, Elizabeth A. Hinnant

Publikováno v: Oncogene. 22(16)

Mice expressing SV40 T-Antigen in liver under control of the phosphoenolpyruvate carboxykinase promoter were generated. By altering the carbohydrate content of the diet, TAg expression, the rate of hepatocyte proliferation and apoptosis, and hence he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c198beea7932becdbfb116ea9b417f09
https://pubmed.ncbi.nlm.nih.gov/12717428

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Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT’s C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver

Autor: Sarah A. Comerford, Robert E. Hammer, Nikolaus Schultz, S. Klapproth, Elizabeth A. Hinnant

Publikováno v: Oncogenesis

Transformation by Simian Virus 40 (SV40) large T antigen (LT) is mediated in large part by its interaction with a variety of cellular proteins at distinct binding domains within LT. While the interaction of LT's N-terminus with the tumor suppressor R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5464dc7a0995cb161e6e89dd4f6e3c27
https://doi.org/10.1038/oncsis.2012.27

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