Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Elizabeth A Comen"'
Autor:
Jennifer D. Brooks, Elizabeth A. Comen, Anne S. Reiner, Irene Orlow, Siok F. Leong, Xiaolin Liang, Lene Mellemkjær, Julia A. Knight, Charles F. Lynch, Esther M. John, Leslie Bernstein, Meghan Woods, David R. Doody, The WECARE Study collaborative group, Kathleen E. Malone, Jonine L. Bernstein
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background Tamoxifen treatment greatly reduces a woman’s risk of developing a second primary breast cancer. There is, however, substantial variability in treatment response, some of which may be attributed to germline genetic variation. CY
Externí odkaz:
https://doaj.org/article/b76fb10b53db43d095312fb86cc18288
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Historically, the link between chronic inflammation and cancer has long been speculated. Only more recently, pre-clinical and epidemiologic data as well as clinical evidence all point to the role of the tumor microenvironment as inextricably connecte
Externí odkaz:
https://doaj.org/article/9313b06bd7d7461db00f24055da2da1e
Autor:
Daniel C. Danila, Thompson N. Doman, Jonathan Landa, David Schaer, Shanu Modi, Elizabeth A. Comen, Matthew Adamow, Jill S. Gluskin, Susan F. Slovin, Michael J. Morris, Suhyun Kang, Manisha Brahmachary, Sonya C. Chapman, David M. J. Hoffman, Rachel Sanford, Jeremy C. Durack, Josef J. Fox, Michelle Carlsen, Ruslan D. Novosiadly, Philomena McAndrew, John S. Kauh, Dana E. Rathkopf, Courtney M. Tate, Danni Yu, Karen A. Autio, Victoria S. Blinder, Phillip Wong, Praneet Kang, Christopher A. Klebanoff, Heather L. McArthur
Publikováno v:
Clin Cancer Res
Purpose: Tumor-associated macrophages correlate with increased invasiveness, growth, and immunosuppression. Activation of the colony-stimulating factor-1 receptor (CSF-1R) results in proliferation, differentiation, and migration of monocytes/macropha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448fc06501a6592a9a8ac8ca34449998
https://doi.org/10.1158/1078-0432.ccr-20-0855
https://doi.org/10.1158/1078-0432.ccr-20-0855
Autor:
Mark E. Robson, Betty Ann Caravella, Mario E. Lacouture, Helen Won, Richard B. Lanman, M. Scaltriti, Neil Vasan, David B. Solit, Payal D. Shah, Aimee Cowan, Maura N. Dickler, Shanu Modi, Ronglai Shen, Elizabeth A. Comen, Weiyi Toy, Bob T. Li, Anne M. Covey, Komal Jhaveri, Sujata Patil, Jorge S. Reis-Filho, Rebecca J. Nagy, Pier Selenica, Pedram Razavi, Michael F. Berger, Stephen Zamora, Larry Norton, Mary Ellen Moynahan, Justin I. Odegaard, David N Brown, Clifford A. Hudis, Edi Brogi, Sarat Chandarlapaty, Andy Singh
Publikováno v:
Nature Cancer. 1:382-393
Alpelisib is a selective inhibitor of PI3Kα, shown to improve outcomes for PIK3CA mutant, hormone receptor positive (HR+) metastatic breast cancers (MBC) when combined with antiestrogen therapy. To uncover mechanisms of resistance, we conducted a de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42df8bb7a3275c5f1e48f36c9fa0c54e
https://doi.org/10.1038/s43018-020-0047-1
https://doi.org/10.1038/s43018-020-0047-1
Autor:
Jorge S. Reis-Filho, Fresia Pareja, Britta Weigelt, Noushin Farnoud, Robert L. Bowman, Guray Akturk, Pier Selenica, Abigail Alon, Elizabeth A. Comen, Felipe C Geyer, Larry Norton, Corinne E. Hill, Ross L. Levine, Maria Kleppe
Publikováno v:
JNCI: Journal of the National Cancer Institute. 112:107-110
Chemotherapy and radiation therapy are the foundations of adjuvant therapy for early-stage breast cancer. As a complication of cytotoxic regimens, breast cancer patients are at risk for therapy-related myeloid neoplasms (t-MNs). These t-MNs are commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62696333a4f414f08caf8ab21b5a36a7
https://doi.org/10.1093/jnci/djz157
https://doi.org/10.1093/jnci/djz157
Autor:
Smita S. Chandran, Y. Liu, Mary Philip, Christopher A. Klebanoff, Tyler Walther, Jonathan Kaye, Peter Lauer, Mojdeh Shakiba, Dmitriy Zamarin, Prerak Trivedi, Hannah Y Wen, Heather Appleby, Andrew Scott, Alexandra Snyder, Niroshana Anandasabapathy, Matthew D. Hellmann, Steven Camara, Olivier Levy, Andrea Schietinger, Laura Menocal, Nasser K. Altorki, Elizabeth A. Comen, Doron Betel, Michael S. Glickman, Paul Zumbo, Matthew R. Femia, Friederike Dündar
Publikováno v:
Nature
Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the functional effector or memory T cell states1–6. Here we identify the nuclear factor TOX as a crucial regulator of the differentiation of tumour-specific T (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c89d0ce3d63de6646be6ef831a2b76
https://doi.org/10.1038/s41586-019-1324-y
https://doi.org/10.1038/s41586-019-1324-y
Autor:
ME Moynahan, Gabriela Chiosis, Monica Fornier, Tony Taldone, S. Patil, S Khoshi, W. Ma, Shanu Modi, Elizabeth A. Comen, Jason S. Lewis, J. Bromberg, Valentina Sterlin, Mark Dunphy, Larry Norton, Komal Jhaveri, Renjing Wang, Anna Rodina
Publikováno v:
Cancer Research. 79:P6-20
Background: The epichaperome is a new cancer target required for tumor survival (Joshi et al. Nature Reviews Cancer 2018). PU-H71 is a synthetic, purine scaffold epichaperome inhibitor that binds to the ATP-binding site of HSP90 specifically when HSP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7316d0d4bc2ea75ad703b3ff3d3a7242
https://doi.org/10.1158/1538-7445.sabcs18-p6-20-03
https://doi.org/10.1158/1538-7445.sabcs18-p6-20-03
Autor:
C DiLauro Abaya, Elizabeth A. Comen, Larry Norton, S. Patil, Micaela Rodine, Heather L. McArthur, Stephen B. Solomon, Jhs Leal
Publikováno v:
Cancer Research. 79:OT2-06
Background: Triple negative breast cancer (TNBC) is a biologically distinct subtype with high risk of early relapse, particularly for patients who do not achieve a pathological complete response (pCR) after neoadjuvant chemotherapy (NAC), with an eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3159979e1a202e53c7ab26a12051d44a
https://doi.org/10.1158/1538-7445.sabcs18-ot2-06-05
https://doi.org/10.1158/1538-7445.sabcs18-ot2-06-05
Autor:
Chau T. Dang, J. Das, J. Bromberg, Quincey LaPlant, Atif J. Khan, Daniel R. Gomez, D.M. Guttmann, Annemarie F. Shepherd, Tiffany A. Traina, Steven Sugarman, Charles M. Rudin, Isabel Ruth Preeshagul, C.J. Tsai, J.M. Mann, Erin F. Gillespie, Shanu Modi, Carla Hajj, Elizabeth A. Comen, Rachel Ann Sanford, M.E. Robson, Wanqing Iris Zhi, Marsha Reyngold, Pamela Drullinsky, A. Iqbal, A.J. Xu, Ayca Gucalp, Jeffrey Girshman, Azadeh Namakydoust, Kenneth K.-S. Ng, Narek Shaverdian, R. Yeh, J.T. Yang, Zhigang Zhang, Simon N. Powell, Daphna Y. Gelblum, Juliana Eng, J.Y. Shin, Andreas Rimner, Andrew D. Seidman, Abraham J. Wu
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 111:1325-1326
Purpose/Objective(s) We hypothesize that there is an oligoprogressive state in metastatic cancer, in which disease control can be improved with local therapy to progressive lesions only. This study therefore evaluated the impact of stereotactic body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0743f07d11bf676da6f1777a7045ff
https://doi.org/10.1016/j.ijrobp.2021.09.014
https://doi.org/10.1016/j.ijrobp.2021.09.014
Autor:
Heather L. McArthur, Elizabeth Anne Comen, Yolanda Bryce, Stephen Barnett Solomon, Jorge Henrique S. Leal, Christina DiLauro Abaya, Cristal Martinez, Reva K Basho, Dorothy J. Park, Philomena McAndrew, Brigid Larkin, William Mills, David B. Page, Staci L. Mellinger, Nicole Fredrich, Nicole Moxon, Sangeetha M. Reddy, Meredith Carter, Sujata Patil, Larry Norton
Publikováno v:
Journal of Clinical Oncology. 40:TPS617-TPS617
TPS617 Background: Local tumor destruction with cryoablation (cryo) induces inflammation and releases antigens that can activate tumor-specific immune responses. Pre-clinically, cryo with checkpoint inhibition augmented tumor-specific immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07461f6a5b29a50021b9af4b9835eff2
https://doi.org/10.1200/jco.2022.40.16_suppl.tps617
https://doi.org/10.1200/jco.2022.40.16_suppl.tps617