Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elizabeth A Aisenbrey"'
Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels
Autor:
Joydeb Majumder, Elizabeth E Torr, Elizabeth A Aisenbrey, Connie S Lebakken, Peter F Favreau, William D Richards, Yanhong Yin, Qiang Chang, William L Murphy
Publikováno v:
Journal of Tissue Engineering, Vol 15 (2024)
The tailorable properties of synthetic polyethylene glycol (PEG) hydrogels make them an attractive substrate for human organoid assembly. Here, we formed human neural organoids from iPSC-derived progenitor cells in two distinct formats: (i) cells see
Externí odkaz:
https://doaj.org/article/86c87a2ea4184847a73652280ca741fb
Autor:
Elizabeth A. Aisenbrey, Elizabeth Torr, Hunter Johnson, Cheryl Soref, William Daly, William L. Murphy
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100261- (2021)
Summary: Pericytes play a critical role in promoting, regulating, and maintaining numerous vascular functions. Their dysfunction is a major contributor to the progression of vascular and neurodegenerative diseases, making them an ideal candidate for
Externí odkaz:
https://doaj.org/article/c41d66c61a254e58bd1a284c75ffc494
Autor:
Andrew A. Tomaschke, Stephanie J. Bryant, Sarah A. Schoonraad, Elizabeth A. Aisenbrey, Mark A. Randolph, Joseph A. Wahlquist, Kristine M. Fischenich, Virginia L. Ferguson
Publikováno v:
Biochem Biophys Res Commun
Focal defects in articular cartilage are unable to self-repair and, if left untreated, are a leading risk factor for osteoarthritis. This study examined cartilage degeneration surrounding a defect and then assessed whether infilling the defect preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2fe939da8ac75e0ae8974122cbe39f
https://doi.org/10.1016/j.bbrc.2019.05.034
https://doi.org/10.1016/j.bbrc.2019.05.034
Publikováno v:
Biomater Sci
Human induced pluripotent stem cells (iPSCs) have emerged as a promising alternative to bone-marrow derived mesenchymal stem/stromal cells for cartilage tissue engineering. However, the effect of biochemical and mechanical cues on iPSC chondrogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d90045bdf4f53876944d15e8ad356c9
https://doi.org/10.1039/c9bm01081e
https://doi.org/10.1039/c9bm01081e
Publikováno v:
Nat Rev Mater
Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse sarcomas, has been used for more than four decades for a myriad of cell-culture applications. However, Matrigel is limited in its applicability to cellular biology, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2457b7d47c2dc90cdabaa63e4db51ec9
https://europepmc.org/articles/PMC7500703/
https://europepmc.org/articles/PMC7500703/
Publikováno v:
Journal of Biomedical Materials Research Part A. 106:2344-2355
Cartilage tissue engineering strategies that use in situ forming degradable hydrogels for mesenchymal stem cell (MSC) delivery are promising for treating chondral defects. Hydrogels that recapitulate aspects of the native tissue have the potential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7dcefd7bbb4dd2d5dc47d4431627b35
https://doi.org/10.1002/jbm.a.36412
https://doi.org/10.1002/jbm.a.36412
Autor:
Joseph A. Wahlquist, Stephanie J. Bryant, Robert R. McLeod, Elizabeth A. Aisenbrey, Callie Fiedler, Chelsea M. Heveran, Virginia L. Ferguson
Publikováno v:
Soft Matter. 12:9095-9104
Current hydrogels used for tissue engineering are limited to a single range of mechanical properties within the replicated tissue construct. We show that repeated in-swelling by a single hydrogel pre-cursor solution into an existing polymerized hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6427514b87e6e9422854e922d9770e
https://doi.org/10.1039/c6sm01768a
https://doi.org/10.1039/c6sm01768a
Autor:
Laurie R. Goodrich, Cecilia Pascual-Garrido, Elizabeth A. Aisenbrey, Stephanie J. Bryant, Francisco Rodriguez-Fontan, Karin A. Payne
Publikováno v:
The American journal of sports medicine. 47(1)
Background: In this study, we investigate the in vitro and in vivo chondrogenic capacity of a novel photopolymerizable cartilage mimetic hydrogel, enhanced with extracellular matrix analogs, for cartilage regeneration. Purpose: To (1) determine wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b517cec7d6d7c95cc970c304be2039
https://pubmed.ncbi.nlm.nih.gov/30481048
https://pubmed.ncbi.nlm.nih.gov/30481048
Publikováno v:
Biomaterials
Mesenchymal stem cells (MSCs) are promising for cartilage regeneration, but readily undergo terminal differentiation. The aim of this study was two-fold: a) investigate physiochemical cues from a cartilage-mimetic hydrogel under dynamic compressive l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c511e412fdf5fb60263587e777ca729
https://pubmed.ncbi.nlm.nih.gov/30391802
https://pubmed.ncbi.nlm.nih.gov/30391802
Autor:
Kristofer K. Westbrook, Elizabeth A. Aisenbrey, Stephanie J. Bryant, Neven J. Steinmetz, H. Jerry Qi
Publikováno v:
Acta Biomaterialia. 21:142-153
A bioinspired multi-layer hydrogel was developed for the encapsulation of human mesenchymal stem cells (hMSCs) as a platform for osteochondral tissue engineering. The spatial presentation of biochemical cues, via incorporation of extracellular matrix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9a9c8885d8cda47d802cad797832cf
https://doi.org/10.1016/j.actbio.2015.04.015
https://doi.org/10.1016/j.actbio.2015.04.015