Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Elizabeth A, Repasky"'
Autor:
Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. MacDonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M. Fan, Jianmin Wang, Philip L. McCarthy, Elizabeth A. Repasky, Hemn Mohammadpour
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy
Externí odkaz:
https://doaj.org/article/38460ce622de479f9a32204e95da4901
Autor:
Taylor P. Uccello, Maggie L. Lesch, Sarah A. Kintzel, Lauren B. Gradzewicz, Lillia Lamrous, Shawn P. Murphy, Fergal J. Fleming, Bradley N. Mills, Joseph D. Murphy, Angela Hughson, Gary Hannon, Jesse Garrett-Larsen, Haoming Qiu, Michael G. Drage, Jian Ye, Nicholas W. Gavras, David C. Keeley, Tanzy M. T. Love, Elizabeth A. Repasky, Edith M. Lord, David C. Linehan, Scott A. Gerber
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-12 (2023)
Abstract Rectal cancer ranks as the second leading cause of cancer-related deaths. Neoadjuvant therapy for rectal cancer patients often results in individuals that respond well to therapy and those that respond poorly, requiring life-altering excisio
Externí odkaz:
https://doaj.org/article/e9b3abc8040b4f838d19d476c4b23ebc
Autor:
Brian Yu, Sung Jun Ma, Michael Khan, Jasmin Gill, Austin Iovoli, Fatemeh Fekrmandi, Mark K. Farrugia, Kimberly Wooten, Vishal Gupta, Ryan McSpadden, Moni A. Kuriakose, Michael R. Markiewicz, Ayham Al-Afif, Wesley L. Hicks, Mukund Seshadri, Andrew D. Ray, Elizabeth A. Repasky, Anurag K. Singh
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Given the role of systematic inflammation in cancer progression, lymphocyte-monocyte ratio (LMR) from peripheral blood has been suggested as a biomarker to assess the extent of inflammation in several solid malignancies. However,
Externí odkaz:
https://doaj.org/article/cb13876a50a8464da6ddcddeffcc4c6b
Autor:
Jianhong Chen, Mark D. Long, Sirinapa Sribenja, Sung Jun Ma, Li Yan, Qiang Hu, Song Liu, Thaer Khoury, Chi-Chen Hong, Elisa Bandera, Anurag K. Singh, Elizabeth A. Repasky, Elizabeth G. Bouchard, Michael Higgins, Christine B. Ambrosone, Song Yao
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-10 (2023)
Abstract Background Disadvantaged socioeconomic position (SEP), including lower educational attainment and household income, may influence cancer risk and outcomes. We hypothesized that DNA methylation could function as an intermediary epigenetic mec
Externí odkaz:
https://doaj.org/article/f1076641aa4049a1a139134b19728f57
Autor:
Paul K Wallace, Thomas Schwaab, Scott I Abrams, Elizabeth A Repasky, Alexis Conway, Jason B Muhitch, Jacky Chow, Adil Khan, Madeline Gaudieri, Brianna J Wasik, Kah Teong Soh, Anurag K Singh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Studies evaluating peripheral patient samples show radiation can modulate immune responses, yet the biological changes in human tumors particularly at the cellular level remain largely unknown. Here, we address how radiation treatment shap
Externí odkaz:
https://doaj.org/article/be083ad959af46eea3224d5aecd46e1e
Autor:
Hemn Mohammadpour, Takemasa Tsuji, Cameron R. MacDonald, Joseph L. Sarow, Hanna Rosenheck, Saeed Daneshmandi, Jee Eun Choi, Jingxin Qiu, Junko Matsuzaki, Agnieszka K. Witkiewicz, Kristopher Attwood, Bruce R. Blazar, Kunle Odunsi, Elizabeth A. Repasky, Philip L. McCarthy
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112250- (2023)
Summary: Abundant donor cytotoxic T cells that attack normal host organs remain a major problem for patients receiving allogeneic hematopoietic cell transplantation (allo-HCT). Despite an increase in our knowledge of the pathobiology of acute graft v
Externí odkaz:
https://doaj.org/article/f1e3b8cf52994b1c9c4108441a3ac6b7
Autor:
Minhyung Kim, Daniel T. Fisher, Paul N. Bogner, Umesh Sharma, Han Yu, Joseph J. Skitzki, Elizabeth A. Repasky
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 8, Pp n/a-n/a (2022)
Abstract Background Vascularized composite tissue allotransplantation (VCA) to replace limbs or faces damaged beyond repair is now possible. The resulting clear benefit to quality of life is a compelling reason to attempt this complex procedure. Unfo
Externí odkaz:
https://doaj.org/article/179e74dc68fd40c5a5c224843613d961
Autor:
Jee Eun Choi, Cameron R. MacDonald, Nishant Gandhi, Gokul Das, Elizabeth A. Repasky, Hemn Mohammadpour
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101389- (2022)
Summary: Metabolic reprogramming is associated with myeloid-derived suppressor cell (MDSC) immunosuppressive function. Here, we outline the process for acquiring MDSCs from human and murine sources for subsequent analysis of fatty acid oxidation, oxi
Externí odkaz:
https://doaj.org/article/9c001372732a414bb47ee73fc7e90fce
Autor:
Taylor P. Uccello, MS, Sarah A. Kintzel, BS, Bradley N. Mills, PhD, Joseph D. Murphy, MS, Jesse Garrett-Larsen, BS, Nicholas G. Battaglia, PhD, Carlos J. Rodriguez, BS, Michael G. Drage, MD, Jian Ye, PhD, Tanzy M.T. Love, PhD, Carl J. Johnston, PhD, Elizabeth A. Repasky, PhD, Haoming Qiu, MD, David C. Linehan, MD, Edith M. Lord, PhD, Scott A. Gerber, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 2, Pp 100867- (2022)
Purpose: Orthotopic tumors more closely recapitulate human cancers than do ectopic models; however, precision targeting of such internal tumors for radiation therapy (RT) without inducing systemic toxicity remains a barrier. We developed an innovativ
Externí odkaz:
https://doaj.org/article/e6a54b79ca5a4a35a5fb31b880e6b168
Autor:
Minhui Chen, Guanxi Qiao, Bonnie L. Hylander, Hemn Mohammadpour, Xiang-Yang Wang, John R. Subjeck, Anurag K. Singh, Elizabeth A. Repasky
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Abscopal responses in patients and preclinical models following radiation therapy are rare. Here the authors show that, in murine tumor models, reducing adrenergic stress or β2-adrenergic receptor signalling not only improves control of the irradiat
Externí odkaz:
https://doaj.org/article/bf540c3fc9a8411c9f4089714a3b4c2c