Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elizabeth A, Misener"'
Autor:
Warshawsky Alan M, Chahrzad Montrose-Rafizadeh, Henry James Robert, Rose T. Ajamie, Viswanath Devanarayan, Nathan Yumibe, Elizabeth A. Misener, Richard W. Zink, Daniel A. Briere, Yihong Li, Eric D. Hawkins, Joseph T. Brozinick, Brad Wilken
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6293-6297
Novel tetrahydroisoquinolines have been developed as potent PPAR ligands. Evaluation of these compounds in PPARgamma responsive models of type 2 diabetes is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94957c4cce8b27e53fdca0e28edb89f8
https://doi.org/10.1016/j.bmcl.2006.09.028
https://doi.org/10.1016/j.bmcl.2006.09.028
Autor:
Donald B. Bennett, Brian Eugene Cunningham, Jill R. Wagner, Burkholder Timothy P, O'toole John Cunningham, Daniel A. Briere, David Mendel, Kelly Wayne Furness, Thomas A. Engler, Eric D. Hawkins, Jon K. Reel, Joseph T. Brozinick, Henry James Robert, Renee Vaughn, Robert M. Campbell, Joshua Ryan Clayton, Mclean Johnathan Alexander, Clive Gideon Diefenbacher, Timothy I. Meier, Richard A. Brier, Angela Lynn Marquart, Bryan D. Anderson, James A. Cook, Warren J. Porter, Yihong Li, Elizabeth A. Misener, Sushant Malhotra
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:899-903
Many 3-aryl-4-(1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl)maleimides exhibit potent GSK3 inhibitory activity (100 nM IC(50)), although few show significant selectivity (100x) versus CDK2, CDK4, or PKCbetaII. However, combining 3-(imidazo[1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a386c90f11d8bbe8af6add872ac1ee74
https://doi.org/10.1016/j.bmcl.2004.12.063
https://doi.org/10.1016/j.bmcl.2004.12.063
Autor:
Lourdes Prieto, Chahrzad Montrose-Rafizadeh, Daniel A. Briere, Elizabeth A. Misener, Tony Y. Zhang, Javier Agejas, Eric D. Hawkins, Rosario Gonzalez, Carlos Lamas, John R. Rizzo, Rafael Ferritto, Francisco Parra, Dawn A. Brooks, Beatrriz Lopez De Uralde, Anne Reifel-Miller, Joseph T. Brozinick, Roger L. Robey, Robert J. Ardecky, James D. Fraser, Charles A. Alt, Warshawsky Alan M, Isabel Rojo, Rhodes Gary Anthony, Samuel R. Wendel, Alicia Torrado, Maria Dolores Martin-Ortega, Jose Alfredo Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:51-55
Herein we describe a series of potent and selective PPARgamma agonists with moderate PPARalpha affinity and little to no affinity for other nuclear receptors. In vivo studies in a NIDDM animal model (ZDF rat) showed that these compounds are efficacio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5cbcaf1bec8052c3f4047fb81eceb5
https://doi.org/10.1016/j.bmcl.2004.10.042
https://doi.org/10.1016/j.bmcl.2004.10.042
Publikováno v:
Families, Systems, & Health. 22:180-192
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d1693723d6408c4c9b7dcee7f6ba8d6
https://doi.org/10.1037/1091-7527.22.2.180
https://doi.org/10.1037/1091-7527.22.2.180
Autor:
James R. Paterniti, James M. Bilakovics, Mccarthy James R, William R. Bensch, Joseph T. Brozinick, Brian A. Oldham, Garret J. Etgen, Kathleen M. Ogilvie, Sha Liu, Christopher John Rito, Carol L. Broderick, Anthony J. Shuker, Robert J. Ardecky, James S. Bean, Elizabeth A. Misener, John S. Tyhonas, Sharon L. Dana, William T. Johnson, Dawn A. Brooks, Raymond F. Kauffman, Chahrzad R. Montrose
Publikováno v:
Diabetes. 51:1083-1087
A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-α/γ agonist, LY465608, was designed to address the major metabolic disturbances of type 2 diabetes. LY465608 altered PPAR-responsive genes in liver and fat of db/d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b450b25eeadc156ea632676a20dd572
https://doi.org/10.2337/diabetes.51.4.1083
https://doi.org/10.2337/diabetes.51.4.1083
Autor:
Warshawsky Alan M, Charles A. Alt, Vance Jennifer Ann, Anne Reifel Miller, Harkness Allen Robert, Henry James Robert, Donald P. Matthews, Minmin Wang, Richard W. Zink, Eric D. Hawkins, Elizabeth A. Misener, Joseph T. Brozinick, Uko E. Udodong, Rhodes Gary Anthony, Chahrzad Montrose-Rafizadeh, Tony Y. Zhang, Shen Quanrong
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(24)
PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701a0bcd6bdbbe7496389752b1e74cb4
https://pubmed.ncbi.nlm.nih.gov/17005394
https://pubmed.ncbi.nlm.nih.gov/17005394
Autor:
Philip W. Iversen, Thomas A. Engler, Daniel A. Briere, Eric D. Hawkins, Michael P. Clay, YiHong Burlingame Li, Queener S, O'toole John Cunningham, Robert M. Campbell, Joshua Ryan Clayton, Clive Gideon Diefenbacher, Elizabeth A. Misener, Jon K. Reel, Terry D. Lindstrom, Warren J. Porter, Vaughn R, Brian Eugene Cunningham, Henry, Richard A. Brier, Kelly Wayne Furness, Sushant Malhotra, Burkholder Timothy P, Joseph T. Brozinick, Owens Rebecca Anne, Angela Lynn Marquart, David Mendel, Thomas E Eessalu, Wagner, Mclean Johnathan Alexander
Publikováno v:
Journal of medicinal chemistry. 47(16)
Glycogen synthase kinase-3 (GSK3) is involved in signaling from the insulin receptor. Inhibitors of GSK3 are expected to effect lowering of plasma glucose similar to insulin, making GSK3 an attractive target for the treatment of type 2 diabetes. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fe6d62503568cadbbd9dbb210bf4f3
https://pubmed.ncbi.nlm.nih.gov/15267232
https://pubmed.ncbi.nlm.nih.gov/15267232
Autor:
Garret J, Etgen, Brian A, Oldham, William T, Johnson, Carol L, Broderick, Chahrzad R, Montrose, Joseph T, Brozinick, Elizabeth A, Misener, James S, Bean, William R, Bensch, Dawn A, Brooks, Anthony J, Shuker, Christopher J, Rito, James R, McCarthy, Robert J, Ardecky, John S, Tyhonas, Sharon L, Dana, James M, Bilakovics, James R, Paterniti, Kathleen M, Ogilvie, Sha, Liu, Raymond F, Kauffman
Publikováno v:
Diabetes. 51(4)
A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-alpha/gamma agonist, LY465608, was designed to address the major metabolic disturbances of type 2 diabetes. LY465608 altered PPAR-responsive genes in liver and fat o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3ddd62954c3b4612390765cc89e207d
https://pubmed.ncbi.nlm.nih.gov/11916929
https://pubmed.ncbi.nlm.nih.gov/11916929
Publikováno v:
Cancer Research. 71:5325-5325
Metastatic bone disease is common in multiple myeloma, breast, prostate, and lung cancer patients and is a frequent cause of morbidity in advanced disease. Metastatic bone tumors destroy bone and cause severe bone remodeling which leads to structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14f30925f8ea2c69ac2aa0819cb6b865
https://doi.org/10.1158/1538-7445.am2011-5325
https://doi.org/10.1158/1538-7445.am2011-5325