Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Elizabeth A, Killion"'
Autor:
Elizabeth A. Killion, Michelle Chen, James R. Falsey, Glenn Sivits, Todd Hager, Larissa Atangan, Joan Helmering, Jae Lee, Hongyan Li, Bin Wu, Yuan Cheng, Murielle M. Véniant, David J. Lloyd
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Here the authors show that this may be explained
Externí odkaz:
https://doaj.org/article/35bda07550384ea78b2522ff1a815550
Autor:
Shu-Chen Lu, Michelle Chen, Larissa Atangan, Elizabeth A. Killion, Renee Komorowski, Yuan Cheng, Chawita Netirojjanakul, James R. Falsey, Marina Stolina, Denise Dwyer, Clarence Hale, Shanaka Stanislaus, Todd Hager, Veena A. Thomas, John M. Harrold, David J. Lloyd, Murielle M. Véniant
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263- (2021)
Summary: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor (GIPR) antagonist antibody (GIPR-Ab) and GLP-1 receptor (GLP-1R) agonis
Externí odkaz:
https://doaj.org/article/6fa1243f07684a9b91237d0446fb0986
Autor:
Elizabeth A. Killion, Andrew R. Reeves, Mahmoud A. El Azzouny, Qing-Wu Yan, Defne Surujon, John D. Griffin, Thomas A. Bowman, Chunyan Wang, Nirupa R. Matthan, Eric L. Klett, Dong Kong, John W. Newman, Xianlin Han, Mi-Jeong Lee, Rosalind A. Coleman, Andrew S. Greenberg
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 43-56 (2018)
Objective: Regulation of fatty acid (FA) metabolism is central to adipocyte dysfunction during diet-induced obesity (DIO). Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), in
Externí odkaz:
https://doaj.org/article/42c15968b17c43c98d7bae19e9948e6b
Autor:
Gabriel Hundeshagen, David N. Herndon, Karel D. Capek, Ludwik K. Branski, Charles D. Voigt, Elizabeth A. Killion, Janos Cambiaso-Daniel, Michaela Sljivich, Andrew De Crescenzo, Ronald P. Mlcak, Michael P. Kinsky, Celeste C. Finnerty, William B. Norbury
Publikováno v:
Critical Care, Vol 21, Iss 1, Pp 1-10 (2017)
Abstract Background Burn patients are prone to infections which often necessitate broad antibiotic coverage. Vancomycin is a common antibiotic after burn injury and is administered alone (V), or in combination with imipenem-cilastin (V/IC) or piperac
Externí odkaz:
https://doaj.org/article/52a9c34029014152bd3344374cabea34
Autor:
Thomas A. Bowman, Kayleigh R. O'Keeffe, Theresa D'Aquila, Qing Wu Yan, John D. Griffin, Elizabeth A. Killion, Deanna M. Salter, Douglas G. Mashek, Kimberly K. Buhman, Andrew S. Greenberg
Publikováno v:
Molecular Metabolism, Vol 5, Iss 3, Pp 210-220 (2016)
Objective: The family of acyl-CoA synthetase enzymes (ACSL) activates fatty acids within cells to generate long chain fatty acyl CoA (FACoA). The differing metabolic fates of FACoAs such as incorporation into neutral lipids, phospholipids, and oxidat
Externí odkaz:
https://doaj.org/article/c75a3426e7aa4e40b744b72527d2cb64
Autor:
Todd Hager, Jae Lee, Hongyan Li, David Lloyd, James R. Falsey, Elizabeth A. Killion, Bin Wu, Larissa Atangan, Yuan Cheng, Michelle Chen, Murielle M. Véniant, Joan Helmering, Glenn Sivits
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Based on the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e345ea930fa8a2a065b4ce5c63e709e9
http://link.springer.com/article/10.1038/s41467-020-18751-8
http://link.springer.com/article/10.1038/s41467-020-18751-8
Autor:
Elizabeth A. Killion, Rajaa Hussien, Artem Shkumatov, Rhian Davies, David J. Lloyd, Murielle M. Véniant, Herve Lebrec, Madeline M. Fort
Publikováno v:
AndrologyREFERENCES. 10(4)
Glucose-dependent insulinotropic polypeptide receptor (Gipr) gene expression has been reported in mouse spermatids and Gipr knockout male mice have previously been reported to have decreased in vitro fertilization, although the role of Gipr signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1235c38e69e39ff25e106227bec129d7
https://pubmed.ncbi.nlm.nih.gov/35224888
https://pubmed.ncbi.nlm.nih.gov/35224888
Autor:
Madeline M. Fort, Yuichiro Yamada, David Lloyd, Murielle M. Véniant, Shu-Chen Lu, Elizabeth A. Killion
Publikováno v:
Endocrine Reviews. 41:1-21
Glucose-dependent insulinotropic polypeptide receptor (GIPR) is associated with obesity in human genome-wide association studies. Similarly, mouse genetic studies indicate that loss of function alleles and glucose-dependent insulinotropic polypeptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccb12e41f93c29400813421c7a4cf4f
https://doi.org/10.1210/endrev/bnz002
https://doi.org/10.1210/endrev/bnz002
Autor:
Elizabeth A. Killion, Yuan Cheng, John M. Harrold, Veena A. Thomas, Shu-Chen Lu, James R. Falsey, Chawita Netirojjanakul, David Lloyd, Clarence Hale, Todd Hager, Shanaka Stanislaus, Marina Stolina, Renee Komorowski, Larissa Atangan, Murielle M. Véniant, Denise Dwyer, Michelle Chen
Publikováno v:
Cell Reports Medicine
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263-(2021)
Cell Reports Medicine, Vol 2, Iss 5, Pp 100263-(2021)
Summary Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor (GIPR) antagonist antibody (GIPR-Ab) and GLP-1 receptor (GLP-1R) agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ac5166f5323cefa07e391f43ee52d4
https://pubmed.ncbi.nlm.nih.gov/34095885
https://pubmed.ncbi.nlm.nih.gov/34095885
Autor:
Thomas A. Bowman, Defne Surujon, Chunyan Wang, Nirupa R Matthan, John D. Griffin, Mi-Jeong Lee, Eric L. Klett, Dong Kong, Andrew S. Greenberg, Rosalind A. Coleman, Xianlin Han, Mahmoud A. El Azzouny, Elizabeth A. Killion, Qing-Wu Yan, Andrew R. Reeves, John W. Newman
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 9, Iss, Pp 43-56 (2018)
Molecular Metabolism, Vol 9, Iss, Pp 43-56 (2018)
Objective Regulation of fatty acid (FA) metabolism is central to adipocyte dysfunction during diet-induced obesity (DIO). Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88e6438d5815da67160d4bf8e7d091a
https://doi.org/10.1016/j.molmet.2018.01.012
https://doi.org/10.1016/j.molmet.2018.01.012