Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Elizabeth, Wille"'
Publikováno v:
Experimental Neurology. 225:74-84
Sirtuins are NAD-dependent deacetylases that regulate important biologic processes including transcription, cell survival and metabolism. Activation of SIRT1, a mammalian sirtuin, extends longevity and increases neuronal survival. An important substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdb9822687b8ba4f116ceb6ef1141e4
https://doi.org/10.1016/j.expneurol.2010.05.006
https://doi.org/10.1016/j.expneurol.2010.05.006
Autor:
Magali Dumont, Daniel J. Ho, Cliona Stack, Karen T. Liby, Charlotte R. Williams, Noel Y. Calingasan, M. Flint Beal, Michael B. Sporn, Elizabeth Wille
Publikováno v:
Free Radical Biology and Medicine. 49:147-158
Oxidative stress is a prominent feature of Huntington's disease (HD) due to mitochondrial dysfunction and the ensuing overproduction of reactive oxygen species (ROS). This phenomenon ultimately contributes to cognitive and motor impairment, as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897c394bc54261119c25236daefe12d5
https://doi.org/10.1016/j.freeradbiomed.2010.03.017
https://doi.org/10.1016/j.freeradbiomed.2010.03.017
Autor:
M. Flint Beal, Noel Y. Calingasan, Arie Neymotin, Mahmoud Kiaei, Susanne Petri, Kenneth Hensley, Charles A. Stewart, Peter H. Schafer, Elizabeth Wille
Publikováno v:
Experimental Neurology. 220:191-197
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which is currently untreatable. Inflammation plays a major role in the pathogenesis of motor neuron death in ALS. Pro-inflammatory cytokines such as tumor necrosis factor-alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20a011bee2064ccd1ffe0a9edceec8a
https://doi.org/10.1016/j.expneurol.2009.08.028
https://doi.org/10.1016/j.expneurol.2009.08.028
Autor:
Elizabeth Wille, Hui Xu, Noel Y. Calingasan, Huan-Lian Chen, Daniel J. Ho, Steven F. Zhang, Lichuan Yang, Anatoly A. Starkov, Gary E. Gibson, Cliona Stack, M. Flint Beal, Qingli Shi
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 2, Pp 320-330 (2009)
The activity of a key mitochondrial tricarboxylic acid cycle enzyme, alpha-ketoglutarate dehydrogenase complex (KGDHC), declines in many neurodegenerative diseases. KGDHC consists of three subunits. The dihydrolipoyl succinyl transferase (DLST) compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94190283fdaec14cdd699f097bda2e03
https://doi.org/10.1016/j.nbd.2009.07.023
https://doi.org/10.1016/j.nbd.2009.07.023
Autor:
Noel Y. Calingasan, Karen M. Smith, Robert J. Ferrante, Lichuan Yang, Elizabeth Wille, M. Flint Beal, Kerry Cormier
Publikováno v:
Journal of Neurochemistry. 109:1427-1439
Coenzyme Q(10) (CoQ(10)) and creatine are promising agents for neuroprotection in neurodegenerative diseases via their effects on improving mitochondrial function and cellular bioenergetics and their properties as antioxidants. We examined whether a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281d8d570be078153b9ba92e00e9fb54
https://doi.org/10.1111/j.1471-4159.2009.06074.x
https://doi.org/10.1111/j.1471-4159.2009.06074.x
Autor:
Magali, Dumont, Elizabeth, Wille, Noel Y, Calingasan, Davide, Tampellini, Charlotte, Williams, Gunnar K, Gouras, Karen, Liby, Michael, Sporn, Carl, Nathan, M, Flint Beal, Michael T, Lin
Publikováno v:
Journal of Neurochemistry. 109:502-512
Oxidative stress is one of the earliest events in the pathogenesis of Alzheimer's disease (AD) and can markedly exacerbate amyloid pathology. Modulation of antioxidant and anti-inflammatory pathways represents an important approach for AD therapy. Sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558c3df49c071c664a5cc8175fac9798
https://doi.org/10.1111/j.1471-4159.2009.05970.x
https://doi.org/10.1111/j.1471-4159.2009.05970.x
Autor:
Noel Y. Calingasan, Daniel J. Ho, Lichuan Yang, M. F. Beal, M.V. Campagna, Gary E. Gibson, Magali Dumont, Elizabeth Wille, Jia Ruan, Qingli Shi
Publikováno v:
Neuroscience. 153:986-996
Mitochondrial defects including reduction of a key mitochondrial tricarboxylic acid cycle enzyme alpha-ketoglutarate-dehydrogenase complex (KGDHC) are characteristic of many neurodegenerative diseases. KGDHC consists of alpha-ketoglutarate dehydrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f858eb7c842cccc70eed522d1b98de
https://doi.org/10.1016/j.neuroscience.2008.02.071
https://doi.org/10.1016/j.neuroscience.2008.02.071
Autor:
Andrew Schomer, Lichuan Yang, M. Flint Beal, Anthony Sireci, Carine Cleren, Elizabeth Wille, Beverly J. Lorenzo, Noel Y. Calingasan
Publikováno v:
Journal of Neurochemistry. 104:1613-1621
Coenzyme Q10 (CoQ10) is a promising agent for neuroprotection in neurodegenerative diseases. We tested the effects of various doses of two formulations of CoQ10 in food and found that administration in the diet resulted in significant protection agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c357a3811030523102fbae9e47b73004
https://doi.org/10.1111/j.1471-4159.2007.05097.x
https://doi.org/10.1111/j.1471-4159.2007.05097.x
Autor:
M. Flint Beal, Noel Y. Calingasan, Junyu Chen, Stefan Lorenzl, Shahin Rafii, Mahmoud Kiaei, Elizabeth Wille, Beate Heissig, Khatuna Kipiani
Publikováno v:
Experimental Neurology. 205:74-81
Whether increased levels of matrix metalloproteinases (MMPs) correspond to a role in the pathogenesis of amyotrophic lateral sclerosis (ALS) needs to be determined and it is actively being pursued. Here we present evidence suggesting that MMP-9 contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74abf382a118e5da00cf183d481ca5ea
https://doi.org/10.1016/j.expneurol.2007.01.036
https://doi.org/10.1016/j.expneurol.2007.01.036
Autor:
Osama A. Alsaied, Noel Y. Calingasan, Jonathan E. Friedman, M. Flint Beal, Mahmoud Kiaei, Juan C. Chavez, Elizabeth Wille, Susanne Petri, Oxana Baranova
Publikováno v:
Journal of Neurochemistry. 102:991-1000
One of the hypotheses for the development of familial amyotrophic lateral sclerosis (ALS) is that mutations in the superoxide dismutase 1 enzyme lead to aberrant properties of the copper within the active site of the enzyme which then causes increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdb4f69d9ab336b3d94922de3f6ce93d
https://doi.org/10.1111/j.1471-4159.2007.04604.x
https://doi.org/10.1111/j.1471-4159.2007.04604.x