Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Elizabeth, Strobert"'
Autor:
Elizabeth Strobert, Laura B. Higginbotham, Alfred Joseph Tector, Joseph M. Ladowski, Andrew B. Adams, Eric M. Walters, David V. Mathews, Alton B. Farris, Joe B. Jenkins, Gregory Martens, Cynthia P. Breeden, Christian P. Larsen, Allison Stephenson, Matthew Tector, Steven C. Kim
Publikováno v:
Am J Transplant
The shortage of available organs remains the greatest barrier to expanding access to transplantation. Despite advances in genetic editing and immunosuppression, survival in experimental models of kidney xenotransplantation has generally been limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b87a5734a4f63a76438da9209baf92
https://doi.org/10.1111/ajt.15329
https://doi.org/10.1111/ajt.15329
Autor:
W. C. Wakwe, Cynthia A. Breeden, Michael C. Lowe, Andrew B. Adams, Alton B. Farris, Mandy L. Ford, Robert M. Townsend, Mustimbo Roberts, David V. Mathews, Joe B. Jenkins, Christian P. Larsen, Steven C. Kim, Elizabeth Strobert
Publikováno v:
American Journal of Transplantation. 17:2285-2299
Recently, newer therapies have been designed to more specifically target rejection in an effort to improve efficacy and limit unwanted toxicity. Belatacept, a CD28-CD80/86 specific reagent, is associated with superior patient survival and graft funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17164be066e3d1af438bd1091092aadb
https://doi.org/10.1111/ajt.14349
https://doi.org/10.1111/ajt.14349
Autor:
Douglas J. Anderson, Elizabeth Strobert, Joe B. Jenkins, Denise J. Lo, Mingqing Song, Francis Leopardi, Allan D. Kirk, Christian P. Larsen
Publikováno v:
Clin Transplant
Belatacept, the CD28-B7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (CNI) alternative in kidney transplantation. Although costimulation blockade (CoB) allows for CNI avoidance, it is associated with increased rates o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ee556464c4060e451d2ee5c092f292
https://pubmed.ncbi.nlm.nih.gov/31006146
https://pubmed.ncbi.nlm.nih.gov/31006146
Autor:
Adriana E. Kajon, James E. Gern, Sujin Lee, Xiaoyan Lu, Martin L. Moore, Elizabeth Strobert, Yury A. Bochkov, Paul Spearman, Krishnendu Roy, Joe B. Jenkins, Ranjna Madan-Lala, Dean D. Erdman, Minh Trang Nguyen, Michael G. Currier
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Nature Communications
Nature Communications
As the predominant aetiological agent of the common cold, human rhinovirus (HRV) is the leading cause of human infectious disease. Early studies showed that a monovalent formalin-inactivated HRV vaccine can be protective, and virus-neutralizing antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e96e725866ea151ae25576afc0c14a3
https://doaj.org/article/1472e837dd8b4360bb69aa5950313aef
https://doaj.org/article/1472e837dd8b4360bb69aa5950313aef
Autor:
Allan D. Kirk, Francis Leopardi, Keith A. Reimann, Christian P. Larsen, Denise J. Lo, Joe B. Jenkins, Nicole A. Turgeon, Mingqing Song, Rijian Wang, Douglas J. Anderson, Elizabeth Strobert
Publikováno v:
American Journal of Transplantation. 16:1456-1464
Costimulation blockade with the fusion protein belatacept provides a desirable side effect profile and improvement in renal function compared with calcineurin inhibition in renal transplantation. This comes at the cost of increased rates of early acu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058ed20000773740b0f850ef07b62876
https://doi.org/10.1111/ajt.13628
https://doi.org/10.1111/ajt.13628
Autor:
Bradley H. Collins, J. Cano, Michael C. Lowe, Joe B. Jenkins, Peter W. Thompson, Benjamin M. Martin, Kannan P. Samy, C.R. Dove, F. Leopardi, Elizabeth Strobert, Alton B. Farris, M. Song, Christian P. Larsen, Allan D. Kirk
Publikováno v:
American Journal of Transplantation. 15:1241-1252
Islet xenotransplantation is a potential treatment for diabetes without the limitations of tissue availability. Although successful experimentally, early islet loss remains substantial and attributed to an instant blood mediated inflammatory reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c1691edc57bedfca70f3123a4404f7
https://doi.org/10.1111/ajt.13098
https://doi.org/10.1111/ajt.13098
Autor:
M. Song, Steven J. Chapin, Denise Lo, Frank V. Leopardi, Allan D. Kirk, Erik E. Karrer, Bruce H. Devens, Elizabeth Strobert, Douglas J. Anderson, Alton B. Farris
Publikováno v:
American Journal of Transplantation. 15:984-992
Costimulation blockade with the B7-CD28 pathway-specific agent belatacept is now used in clinical kidney transplantation, but its efficacy remains imperfect. Numerous alternate costimulatory pathways have been proposed as targets to synergize with be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecba3c405492bc31bde3f4a6ae175b2d
https://doi.org/10.1111/ajt.13100
https://doi.org/10.1111/ajt.13100
Autor:
Michael J. Ricciardi, Diogo M. Magnani, Cassia G. T. Silveira, Sherrie Jean, David E. Lee, Dennis R. Burton, Elizabeth Strobert, Lucas Gonzalez-Nieto, Nathan D. Grubaugh, Aline Domingues, Myrna C. Bonaldo, Guido Silvestri, Varian K. Bailey, Devin Sok, Khoa Le, Esper G. Kallas, Bryan Briney, Ann Chahroudi, Thomas H. Vanderford, Nathan Beutler, David I. Watkins, Thomas F. Rogers, Nuria Pedreño-Lopez, Erica E. Okwuazi, Stephen S. Whitehead, Mauricio A. Martins, Martin J. Gutman, Alexander Strubel, Helen S. Maxwell, Ronald C. Desrosiers
Publikováno v:
Science Translational Medicine. 9
Therapies to prevent maternal Zika virus (ZIKV) infection and its subsequent fetal developmental complications are urgently required. We isolated three potent ZIKV-neutralizing monoclonal antibodies (nmAbs) from the plasmablasts of a ZIKV-infected pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82006eb790f91928f254041a18bf376f
https://doi.org/10.1126/scitranslmed.aan8184
https://doi.org/10.1126/scitranslmed.aan8184
Autor:
Maria E. Fuentes, Ying Dong, Christian P. Larsen, Cynthia P. Breeden, William H. Kitchens, Elizabeth Strobert, David V. Mathews, Mandy L. Ford, Andrew B. Adams
Publikováno v:
JCI Insight. 2
The potential of costimulation blockade to serve as a novel transplant immunosuppression strategy has been explored for over 20 years, culminating in the recent clinical approval of belatacept for renal transplant patients. Despite improving long-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb709b3bf1adf640d72fe8e923519f2
https://doi.org/10.1172/jci.insight.90317
https://doi.org/10.1172/jci.insight.90317
Publikováno v:
Journal of Comparative Pathology. 149:524-528
Summary A 25-year-old, female rhesus macaque (Macaca mulatta) presented with a history of weight loss despite a normal appetite and supportive care. The animal was humanely destroyed due to poor prognosis. Post-mortem examination revealed a focally e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b935e3cc1683977634e343b127574a61
https://doi.org/10.1016/j.jcpa.2013.06.005
https://doi.org/10.1016/j.jcpa.2013.06.005