Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Elizabeth, Skellam"'
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Natural products are small molecules synthesized by fungi, bacteria and plants, which historically have had a profound effect on human health and quality of life. These natural products have evolved over millions of years resulting in specif
Externí odkaz:
https://doaj.org/article/251c7f13773f47fbb5057defe67cc987
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 321-330 (2024)
Several under-explored Aspergillus sp. produce intriguing heptapeptides containing a γ-aminobutyric acid (GABA) residue with as yet unknown biological functions. In this study, a new GABA-containing heptapeptide – unguisin J (1) – along with kno
Externí odkaz:
https://doaj.org/article/46568e21c00244a1b7a147d43b796093
Autor:
Elizabeth Skellam
Publikováno v:
Fungal Biology and Biotechnology, Vol 9, Iss 1, Pp 1-25 (2022)
Abstract Fungal specialized metabolites play an important role in the environment and have impacted human health and survival significantly. These specialized metabolites are often the end product of a series of sequential and collaborating biosynthe
Externí odkaz:
https://doaj.org/article/19732ed39f224307b08ab6629e9f38a3
Publikováno v:
Journal of Fungi, Vol 8, Iss 4, p 355 (2022)
Trichoderma reesei (Hypocrea jecorina) was developed as a microbial cell factory for the heterologous expression of fungal secondary metabolites. This was achieved by inactivation of sorbicillinoid biosynthesis and construction of vectors for the rap
Externí odkaz:
https://doaj.org/article/c15ec1a86dbd47999dd014647db6ffd8
Publikováno v:
Journal of Fungi, Vol 7, Iss 12, p 1085 (2021)
Microbial natural products have had phenomenal success in drug discovery and development yet form distinct classes based on the origin of their native producer. Methods that enable metabolic engineers to combine the most useful features of the differ
Externí odkaz:
https://doaj.org/article/707949a162434bf6adf3aa79931b3919
Autor:
Elizabeth Skellam
Publikováno v:
Natural Product Reports. 39:754-783
Covering: 1999 up to 2021Fungal polyketides encompass a range of structurally diverse molecules with a wide variety of biological activities. The giant multifunctional enzymes that synthesize polyketide backbones remain enigmatic, as do many of the t
Publikováno v:
Angewandte Chemie (International Ed. in English)
The polyketide synthase (PKS)‐like protein TerB, consisting of inactive dehydratase, inactive C‐methyltransferase, and functional ketoreductase domains collaborates with the iterative non reducing PKS TerA to produce 6‐hydroxymellein, a key pat
Publikováno v:
Chemical Communications. 56:10934-10937
Sorbicillinoids are a large family of fungal secondary metabolites with a diverse range of structures and numerous bioactivites, some of which have pharmaceutical potential. The flavin-dependent monooxygenase SorD from Penicillium chrysogenum (PcSorD
Autor:
Elizabeth, Skellam
Publikováno v:
Natural product reports. 39(4)
Covering: 1999 up to 2021Fungal polyketides encompass a range of structurally diverse molecules with a wide variety of biological activities. The giant multifunctional enzymes that synthesize polyketide backbones remain enigmatic, as do many of the t
Publikováno v:
Journal of Fungi
Microbial natural products have had phenomenal success in drug discovery and development yet form distinct classes based on the origin of their native producer. Methods that enable metabolic engineers to combine the most useful features of the differ