Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

Autor: Daniel Butler, Christopher Mozsary, Cem Meydan, Jonathan Foox, Joel Rosiene, Alon Shaiber, David Danko, Ebrahim Afshinnekoo, Matthew MacKay, Fritz J. Sedlazeck, Nikolay A. Ivanov, Maria Sierra, Diana Pohle, Michael Zietz, Undina Gisladottir, Vijendra Ramlall, Evan T. Sholle, Edward J. Schenck, Craig D. Westover, Ciaran Hassan, Krista Ryon, Benjamin Young, Chandrima Bhattacharya, Dianna L. Ng, Andrea C. Granados, Yale A. Santos, Venice Servellita, Scot Federman, Phyllis Ruggiero, Arkarachai Fungtammasan, Chen-Shan Chin, Nathaniel M. Pearson, Bradley W. Langhorst, Nathan A. Tanner, Youngmi Kim, Jason W. Reeves, Tyler D. Hether, Sarah E. Warren, Michael Bailey, Justyna Gawrys, Dmitry Meleshko, Dong Xu, Mara Couto-Rodriguez, Dorottya Nagy-Szakal, Joseph Barrows, Heather Wells, Niamh B. O’Hara, Jeffrey A. Rosenfeld, Ying Chen, Peter A. D. Steel, Amos J. Shemesh, Jenny Xiang, Jean Thierry-Mieg, Danielle Thierry-Mieg, Angelika Iftner, Daniela Bezdan, Elizabeth Sanchez, Thomas R. Campion, John Sipley, Lin Cong, Arryn Craney, Priya Velu, Ari M. Melnick, Sagi Shapira, Iman Hajirasouliha, Alain Borczuk, Thomas Iftner, Mirella Salvatore, Massimo Loda, Lars F. Westblade, Melissa Cushing, Shixiu Wu, Shawn Levy, Charles Chiu, Robert E. Schwartz, Nicholas Tatonetti, Hanna Rennert, Marcin Imielinski, Christopher E. Mason

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Here, using clinical samples and autopsy tissues, the authors combine fast-colorimetric test (LAMP) for SARS-CoV-2 infection and large-scale shotgun metatranscriptomics for host, viral, and microbial profiling and provide a map of the viral genetic f

Externí odkaz: https://doaj.org/article/e049d27579f84e2b9f12b7b11bc7c436

Caracterización fenotípica de genotipos de dos poblaciones naturales de Sorghastrum pellitum (Poaceae) del sudeste bonaerense

Autor: María Lis Echeverría, Gabriela Agustina Leofanti, Gisele Elizabeth Sanchez, María de las Mercedes Echeverría

Publikováno v: Boletín de la Sociedad Argentina de Botánica, Vol 56, Iss 4 (2021)

Introducción y objetivos: Sorghastrum pellitum es una Gramínea nativa de Sudamérica de gran potencial ornamental. Debido a la demanda de nuevas especies nativas por el mercado floricultor, resulta importante conocer si las plantas de esta especie

Externí odkaz: https://doaj.org/article/8eaef32c83b042c99847a418c97d8c0e

A significant portion of college students are not aware of HPV disease and HPV vaccine recommendations

Autor: Caitlyn Kellogg, Janella Shu, Ayana Arroyo, Ngoc Tuyen Dinh, Nia Wade, Elizabeth Sanchez, Ozlem Equils

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 15, Iss 7-8, Pp 1760-1766 (2019)

There is limited data on the HPV immunization status of Latino/Hispanic youth in the USA. In Los Angeles County in 2015, 54,973 (34.3%) college students were of Latino/Hispanic background. We examined Los Angeles County college students’ awareness

Externí odkaz: https://doaj.org/article/777a1f9cc6664795992b49a4ef866f62

Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women

Autor: María Fernanda Garces, Haiver Antonio Rodriguez - Navarro, Julieth Daniela Buell - Acosta, Alvaro Javier Burgos - Cardenas, Roberto Franco - Vega, Luis Miguel Maldonado - Acosta, Javier Eslava - Schmalbach, Arturo José Parada - Baños, Andres Castro - Pinzon, Elizabeth Sanchez, Edith Angel - Muller, Ezequiel Lacunza, Justo P. Castaño, Carlos Dieguez, Rubén Nogueiras, Ariel Ivan Ruiz - Parra, Jorge Eduardo Caminos

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

ObjectiveAngiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its re

Externí odkaz: https://doaj.org/article/6e875b5b540041dfabafcd51bf6db24b

Persistent severe acute respiratory distress syndrome for the prognostic enrichment of trials.

Autor: Elizabeth Sanchez, David R Price, Kuei-Pin Chung, Clara Oromendia, Augustine M K Choi, Edward J Schenck, Ilias I Siempos

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0227346 (2020)

BackgroundAcute respiratory distress syndrome (ARDS) is heterogeneous. As an indication of the heterogeneity of ARDS, there are patients whose syndrome improves rapidly (i.e., within 24 hours), others whose hypoxemia improves gradually and still othe

Externí odkaz: https://doaj.org/article/4638db1b8ab24e24ac988b464c20e1da