Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Elizabeth, Pohler"'
Autor:
Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses. Here we solve the cryoEM structure of the IL-11 recept
Externí odkaz:
https://doaj.org/article/bbc396d2171b448a8f4b408bf1d66f66
Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100417- (2021)
Summary: Stable isotope labeling by amino acid-based high-resolution phosphoproteomics is a powerful technique that allows for direct comparison of cells stimulated under different experimental conditions. This feature makes it the ideal methodology
Externí odkaz:
https://doaj.org/article/5df94d1deb984c8f8a873b94c098fbc3
Autor:
Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Maximillian Hafer, Paul K Fyfe, Elizabeth Pohler, Silvia Gaggero, Martín López-García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-París, Ignacio Moraga
Publikováno v:
eLife, Vol 10 (2021)
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological rol
Externí odkaz:
https://doaj.org/article/036f2f9b6d674d24920c5291fa65c2f9
Autor:
Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga
Publikováno v:
eLife, Vol 8 (2019)
Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes. We have engineered IL-6 variants with different affinities to gp130 to i
Externí odkaz:
https://doaj.org/article/1b051ad15afd4701b89407a5956a40df
Autor:
Alison McFarlane, Junel Sotolongo Bellón, Thomas Meyer, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga
Cytokines dimerize/oligomerize surface receptors to activate signaling. While cytokine receptors preferentially bind only one member of the JAK family, ancestral cytokine receptors, such as Gp130, promiscuously recruit different JAKs to elicit their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b708dcd13498ad0f993f3799938214a9
https://doi.org/10.1101/2023.05.24.542077
https://doi.org/10.1101/2023.05.24.542077
Publikováno v:
The FEBS journalReferences.
Cytokines are soluble factors vital for mammalian physiology. Cytokines elicit highly pleiotropic activities, characterized by their ability to induce a wide spectrum of functional responses in a diverse range of cell subsets, which makes their study
Autor:
Elizabeth Pohler, Ignacio Moraga, Suman Mitra, Martín López-García, Jacob Piehler, Grant Lythe, Stephan Wilmes, Silvia Gaggero, Charles Taylor, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Carmen Molina-París, Maximillian Hafer, T. Guerrier, David Launay, Paul K. Fyfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a345388a0ce6d98b032f01ba82ca9a3
https://doi.org/10.7554/elife.66014.sa2
https://doi.org/10.7554/elife.66014.sa2
Autor:
Silvia Gaggero, David Launay, Jacob Piehler, Polly-Anne Jeffrey, Stephan Wilmes, Grant Lythe, Ignacio Moraga, Jonathan Martinez-Fabregas, Charles Taylor, Suman Mitra, Martín López-García, Elizabeth Pohler, Maximillian Hafer, T. Guerrier, Carmen Molina-París, Paul K. Fyfe
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological rol
Autor:
Maximillian Hafer, T. Guerrier, Paul K. Fyfe, David Launay, Carmen Molina-París, Polly-Anne Jeffrey, Stephan Wilmes, Elizabeth Pohler, Grant Lythe, Martín López-García, Jonathan Martinez-Fabregas, Mitra Suman, Jacob Piehler, Ignacio Moraga, Silvia Gaggero
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f5c1c8cfd65bc7f0733b6275d7f5a52
https://doi.org/10.1101/2021.01.08.425379
https://doi.org/10.1101/2021.01.08.425379
Autor:
Ignacio Moraga, Suman Mitra, Adeline Cozzani, Majid Kazemian, Elizabeth Pohler, Stephan Wilmes, Jonathan Martinez-Fabregas, Luopin Wang
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2020, 33, pp.108545-. ⟨10.1016/j.celrep.2020.108545⟩
Cell Reports, 2020, 33, pp.108545-. ⟨10.1016/j.celrep.2020.108545⟩
Cell Reports, Elsevier Inc, 2020, 33, pp.108545-. ⟨10.1016/j.celrep.2020.108545⟩
Cell Reports, 2020, 33, pp.108545-. ⟨10.1016/j.celrep.2020.108545⟩
Summary Cytokines are highly pleiotropic ligands that regulate the immune response. Here, using interleukin-6 (IL-6) as a model system, we perform detailed phosphoproteomic and transcriptomic studies in human CD4+ T helper 1 (Th-1) cells to address t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8eee974fe9898f8d81056d348dfb05
https://hal.archives-ouvertes.fr/hal-03492639
https://hal.archives-ouvertes.fr/hal-03492639