Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Elizabeth, Matthes"'
Autor:
Graeme W. Carlile, Qi Yang, Elizabeth Matthes, Jie Liao, Véronique Birault, Helen F. Sneddon, Darren L. Poole, Callum J. Hall, John W. Hanrahan, David Y. Thomas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER). Partial rescue of the
Externí odkaz:
https://doaj.org/article/6c974b2051ad451a915f788a93fa1833
Autor:
Patrick Kim Chiaw, Christine Hantouche, Michael J H Wong, Elizabeth Matthes, Renaud Robert, John W Hanrahan, Alvin Shrier, Jason C Young
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220984 (2019)
Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degra
Externí odkaz:
https://doaj.org/article/80281f7f22984ccf97aa287ac7cca643
Autor:
Elizabeth Matthes, Julie Goepp, Carolina Martini, Jiajie Shan, Jie Liao, David Y. Thomas, John W. Hanrahan
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Interest in precision medicine has grown in recent years due to the variable clinical benefit provided by some medications, their cost, and by new opportunities to tailor therapies to individual patients. In cystic fibrosis it may soon be possible to
Externí odkaz:
https://doaj.org/article/1125c634de6d439eb5cd4b9a631d19ee
Autor:
Christopher Moraes, Sonya Kouthouridis, John W. Hanrahan, Carolina Martini, Elizabeth Matthes, Julie Goepp
Publikováno v:
Integr Biol (Camb)
Culture at the air–liquid interface is broadly accepted as necessary for differentiation of cultured epithelial cells towards an in vivo-like phenotype. However, air–liquid interface cultures are expensive, laborious and challenging to scale for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb581a3f703052fcc505131aa7c1059
https://doi.org/10.1093/intbio/zyab002
https://doi.org/10.1093/intbio/zyab002
Autor:
Graeme W, Carlile, Qi, Yang, Elizabeth, Matthes, Jie, Liao, Véronique, Birault, Helen F, Sneddon, Darren L, Poole, Callum J, Hall, John W, Hanrahan, David Y, Thomas
Publikováno v:
Scientific reports. 12(1)
Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER). Partial rescue of the most com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::070682b4642869394a56f6fafdd2f765
https://pubmed.ncbi.nlm.nih.gov/35302062
https://pubmed.ncbi.nlm.nih.gov/35302062
Autor:
Dusik Kim, Asmahan Abu-Arish, Marc A. Tewfik, Saul Frenkiel, John W. Hanrahan, Arnaud Billet, Elizabeth Matthes, Julie Goepp, Junwei Huang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 60:705-716
Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport mechanisms in the airways are not well understood. cAMP stimulates anion efflux through the cystic fibrosis (CF) transmembrane conductance regulator (CFTR; ABCC7) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb59bd484df9d5707365978ae987b36
https://doi.org/10.1165/rcmb.2018-0158oc
https://doi.org/10.1165/rcmb.2018-0158oc
Publikováno v:
Current Opinion in Pharmacology. 34:105-111
These are exciting times in the development of therapeutics for cystic fibrosis (CF). New correctors and potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) are being developed in academic laboratories and pharmaceutical co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ca9fae34a9ed80bfd38e1c381c5eea
https://doi.org/10.1016/j.coph.2017.09.016
https://doi.org/10.1016/j.coph.2017.09.016
Autor:
Andrea Armirotti, Daniela Guidone, Elizabeth Matthes, Alan S. Verkman, John W. Hanrahan, Deborah M. Cholon, Clarissa Braccia, Puay-Wah Phuan, Gergely L. Lukacs, Nicoletta Pedemonte, Valeria Tomati, Luis J. V. Galietta, Guido Veit, Martina Gentzsch
Publikováno v:
Scientific reports, vol 9, iss 1
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abe56d7927ad9f24071d894ba136c91
https://escholarship.org/uc/item/049193dx
https://escholarship.org/uc/item/049193dx
Autor:
John W. Hanrahan, Christine Hantouche, Renaud Robert, Michael J.H. Wong, Jason C. Young, Elizabeth Matthes, Patrick Kim Chiaw, Alvin Shrier
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0220984 (2019)
PLoS ONE, Vol 14, Iss 8, p e0220984 (2019)
Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167ae493f1e22029bdae7afffbeaedb5
https://pubmed.ncbi.nlm.nih.gov/31408507
https://pubmed.ncbi.nlm.nih.gov/31408507
Autor:
Dusik Kim, Arnaud Billet, Junwei Huang, Asmahan Abu-Arish, Julie Goepp, John W. Hanrahan, Elizabeth Matthes, Marc A. Tewfik, Saul Frenkiel
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2019, 60 (6), pp.705-716. ⟨10.1165/rcmb.2018-0158OC⟩
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2019, 60 (6), pp.705-716. ⟨10.1165/rcmb.2018-0158OC⟩
International audience; Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport mechanisms in the airways are not well understood. cAMP stimulates anion efflux through the cystic fibrosis (CF) transmembrane conductance r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3e6fcd661e2c42711d00e1a2bc3d30
https://hal.archives-ouvertes.fr/hal-03145546/document
https://hal.archives-ouvertes.fr/hal-03145546/document