Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elizabeth, Hutto"'
Antibody-mediated targeting of TNFR2 activates CD8 + T cells in mice and promotes antitumor immunity
Autor:
Wenlian Qiao, James Qiu, James Lulo, Jian Tang, Anne-Sophie Dugast, Ross B. Fulton, Galina Craig, Stephanie Grabow, Maja Razlog, James F. Sampson, Eric M. Tam, Sonia Feau, Alexander Koshkaryev, Neeraj Kohli, Kathy Zhang, Yang Jiao, Lia Luus, Adam Camblin, Jennifer Richards, Christina S. F. Wong, Daryl C. Drummond, James Suchy, Aniela Jakubowski, Michael Croft, Marco Muda, James D. Marks, Elizabeth Hutto, Vinodh B. Kurella, Yu Zhou, Andreas Raue, Hong Zhang, Lihui Xu, Fabien Dépis, Sandeep Kumar, Violette Paragas
Publikováno v:
Science Translational Medicine. 11
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (Tregs) in autoimm
Autor:
Eric M, Tam, Ross B, Fulton, James F, Sampson, Marco, Muda, Adam, Camblin, Jennifer, Richards, Alexander, Koshkaryev, Jian, Tang, Vinodh, Kurella, Yang, Jiao, Lihui, Xu, Kathy, Zhang, Neeraj, Kohli, Lia, Luus, Elizabeth, Hutto, Sandeep, Kumar, James, Lulo, Violette, Paragas, Christina, Wong, James, Suchy, Stephanie, Grabow, Anne-Sophie, Dugast, Hong, Zhang, Fabien, Depis, Sonia, Feau, Aniela, Jakubowski, Wenlian, Qiao, Galina, Craig, Maja, Razlog, James, Qiu, Yu, Zhou, James D, Marks, Michael, Croft, Daryl C, Drummond, Andreas, Raue
Publikováno v:
Science translational medicine. 11(512)
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (T
Autor:
Elizabeth Hutto, John Marshall, Gregory A. Grabowski, Kerry Anne McEachern, Svetlana Komarnitsky, John J. Fung, James A. Shayman, Johannes M. F. G. Aerts, Diane Copeland, Seng H. Cheng, Craig Siegel, Wei-Lien Chuang
Publikováno v:
Molecular genetics and metabolism, 91(3), 259-267. Academic Press Inc.
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An approach to treating Gaucher disease is substrate inhibition therapy which seeks to abate the aberrant lysosomal accumulation of glucosylceramide. We have identified a novel inhibitor of glucosylceramide synthase (Genz-112638) and assessed its act
Autor:
Elizabeth Hutto, Wei-Lien Chuang, Gregory A. Grabowski, Seng H. Cheng, Kerry Anne McEachern, John Marshall, Jennifer B. Nietupski, Jennifer Johnson, Donna Armentano
Publikováno v:
The Journal of Gene Medicine. 8:719-729
Background Gaucher disease is the most common of the lysosomal storage disorders. The primary manifestation is the accumulation of glucosylceramide (GL-1) in the macrophages of liver and spleen (Gaucher cells), due to a deficiency in the lysosomal hy
Autor:
Sirkka, Kyostio-Moore, Bindu, Nambiar, Elizabeth, Hutto, Patty J, Ewing, Susan, Piraino, Patricia, Berthelette, Cathleen, Sookdeo, Gloria, Matthews, Donna, Armentano
Publikováno v:
Comparative medicine. 61(4)
Osteoarthritis is a common joint disease that currently lacks disease-modifying treatments. Development of therapeutic agents for osteoarthritis requires better understanding of the disease and cost-effective in vivo models that mimic the human disea
Autor:
Cecile Rouleau, Beverly A. Teicher, Yao-Shi Fu, Robert Smale, Gina Wallar, Glenn Miller, Guodong Hui, Yi Ren, Steven Schmid, Bruce Horten, Craig Jones, Fei Wang, Elizabeth Hutto, Maritza Curiel, Robert Fogle, Stephanie Roth, Roy Krumbholz, Rebecca G. Bagley
Publikováno v:
International Journal of Oncology.
We previously surveyed the expression of endosialin/ CD248/TEM-1 by immunohistochemistry in human clinical specimens of sarcomas and documented expression in tumor cells, stromal cells and vasculature. In the present study, we completed a retrospecti
Autor:
Sandra Dethlefsen, Elizabeth Hutto, Mindy Zhang, Stephen Duguay, Brenda Richards, Stephen Rapko
Publikováno v:
Tissue engineering. Part C, Methods. 16(6)
Methods for the lineage identification of cell or tissue-engineered therapeutics must provide a high degree of performance to confidently distinguish the intended cell type from other lineages that could be present in the finished product. For many a
Autor:
G.A. Grabowski, Wei-Lien Chuang, Craig Siegel, Elizabeth Hutto, Diane Copeland, Kerry Anne McEachern, Ronald K. Scheule, James A. Shayman, Seng H. Cheng, John Marshall
Publikováno v:
Journal of inherited metabolic disease. 33(3)
Gaucher disease is caused by a deficiency of the lysosomal enzyme glucocerebrosidase (acid beta-glucosidase), with consequent cellular accumulation of glucosylceramide (GL-1). The disease is managed by intravenous administrations of recombinant gluco
Autor:
Johanne Kaplan, Jacqueline Shields, Michael J. Turner, William M. Siders, Bruce L. Roberts, Elizabeth Hutto, Yanping Hu, Matthew Gale
Publikováno v:
Immunology. 128(2)
Alemtuzumab is a humanized monoclonal antibody against CD52, an antigen found on the surface of normal and malignant lymphocytes. It is approved for the treatment of B-cell chronic lymphocytic leukaemia and is undergoing Phase III clinical trials for
Autor:
Sheila Cummings Sm Macri, Elizabeth Curran, Rosemary Santos, Miguel Sena-Esteves, Diane Golebiowski, Julie G. Pilitsis, Elizabeth Hutto, Wael F. Asaad, Keiko Y. Petrosky, Nina Bishop, Kajo van der Marel, Matthew J. Gounis, Elena Balkanska-Sinclair, Douglas R. Martin
Publikováno v:
Molecular Therapy. 23:S283
The GM2 gangliosidoses are lysosomal storage disorders that encompass both Tay-Sachs and Sandhoff diseases. These diseases are associated with deficiencies in the lysosomal enzyme β-N-acetylhexosaminidase (HexA). These deficiencies result in accumul