Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2

Autor: Ranjan K. Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Störmer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H. Schmidt, Deep Chatterjee, Joshua A. David, Els Pardon, Thomas U. Schwartz, Stefan Knapp, Eileen J. Kennedy, Jan Steyaert, Friedrich W. Herberg, Arjan Kortholt, Christian Johannes Gloeckner, Wim Versées

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 119(9):e2112712119. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America 119(9), e2112712119 (2022). doi:10.1073/pnas.2112712119

Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson's disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec9137a034b6629ae019cb5b5d3957f
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98457

Nanobodies as allosteric modulators of Parkinson’s disease-associated LRRK2

Autor: Giambattista Guaitoli, Ranjan Kumar Singh, Laura Van Rillaer, Els Pardon, Christian Johannes Gloeckner, Eliza Störmer, Ahmed Soliman, Deep Chatterjee, Thomas Dal Maso, Stefan Knapp, Arjan Kortholt, Jan Steyaert, Felix von Zweydorf, Eileen J. Kennedy, Sven H. Schmidt, Friedrich W. Herberg, Wim Versées

Mutations in the gene coding for Leucine-Rich Repeat Kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson’s disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39d780491f3d0d4ed084ae130620a85
https://doi.org/10.1101/2021.08.30.458082