Fibroblast-like cells change gene expression of bone remodelling markers in transwell cultures

Autor: Eliza S. Hartmann, Sabine Schluessel, Miriam I. Köhler, Felicitas Beck, Julia I. Redeker, Burkhard Summer, Veronika Schönitzer, Andreas Fottner, Susanne Mayer-Wagner

Publikováno v: European Journal of Medical Research, Vol 25, Iss 1, Pp 1-12 (2020)

Abstract Introduction Periprosthetic fibroblast-like cells (PPFs) play an important role in aseptic loosening of arthroplasties. Various studies have examined PPF behavior in monolayer culture systems. However, the periprosthetic tissue is a three-di

Externí odkaz: https://doaj.org/article/53bc3cf378a64d019c93ee2ac412830b

Impact of Periprosthetic Fibroblast-Like Cells on Osteoclastogenesis in Co-Culture with Peripheral Blood Mononuclear Cells Varies Depending on Culture System

Autor: Andreas Fottner, Miriam I. Koehler, Felicitas Beck, Baerbel Schmitt, Susanne Mayer-Wagner, Marina Unger, Burkhard Summer, Martijn van Griensven, Eliza S. Hartmann, Julia I. Redeker, Sabine Schluessel

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2583 (2019)
Volume 20
Issue 10
International journal of molecular sciences, 20(10):2583. Multidisciplinary Digital Publishing Institute (MDPI)

Co-culture studies investigating the role of periprosthetic fibroblasts (PPFs) in inflammatory osteoclastogenesis reveal contrary results, partly showing an osteoprotective function of fibroblasts and high OPG expression in monolayer. These data disa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdabf1c37ee1d947909f8686cadabd8
https://doi.org/10.3390/ijms20102583

Immobilization of Denosumab on Titanium Affects Osteoclastogenesis of Human Peripheral Blood Monocytes

Autor: Sabine Schluessel, Andreas Fottner, Paul J. Kostenuik, Julia I. Redeker, Marina Unger, Martijn van Griensven, Jan Michael, Susanne Mayer-Wagner, Rene Beutner, Eliza S. Hartmann, Baerbel Schmitt, Miriam I. Koehler, Dieter Scharnweber, Burkhard Summer, Karl-Heinz Kunzelmann, Felicitas Beck

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 5
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1002 (2019)
International journal of molecular sciences, 20(5):1002. Multidisciplinary Digital Publishing Institute (MDPI)

Immobilization of proteins has been examined to improve implant surfaces. In this study, titanium surfaces were modified with nanofunctionalized denosumab (cDMAB), a human monoclonal anti-RANKL IgG. Noncoding DNA oligonucleotides (ODN) served as link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee58e8738d71feb31e8b23f8c037a5c
https://mediatum.ub.tum.de/doc/1546329/document.pdf