Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Eliya Bitman-Lotan"'
Autor:
Rostislav Novak, Yamen Abu Ahmad, Michael Timaner, Eliya Bitman-Lotan, Avital Oknin-Vaisman, Roi Horwitz, Oliver Hartmann, Michaela Reissland, Viktoria Buck, Mathias Rosenfeldt, David Nikomarov, Markus Elmar Diefenbacher, Yuval Shaked, Amir Orian
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-12 (2022)
Abstract Molecular understanding of osteogenic differentiation (OD) of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for regenerative medicine and has direct implications for cancer. We report that the RNF4 ubiquitin ligase i
Externí odkaz:
https://doaj.org/article/b0277c5b77ee4bf686658fdcd6fc4695
Autor:
Neta Erez, Lena Israitel, Eliya Bitman-Lotan, Wing H Wong, Gal Raz, Dayanne V Cornelio-Parra, Salwa Danial, Na'ama Flint Brodsly, Elena Belova, Oksana Maksimenko, Pavel Georgiev, Todd Druley, Ryan D Mohan, Amir Orian
Publikováno v:
eLife, Vol 10 (2021)
A hallmark of aging is loss of differentiated cell identity. Aged Drosophila midgut differentiated enterocytes (ECs) lose their identity, impairing tissue homeostasis. To discover identity regulators, we performed an RNAi screen targeting ubiquitin-r
Externí odkaz:
https://doaj.org/article/cff4c8a77cb2428b815197729e5e45f4
Publikováno v:
Cells, Vol 10, Iss 9, p 2374 (2021)
A hallmark of cancer is dysregulated protein turnover (proteostasis), which involves pathologic ubiquitin-dependent degradation of tumor suppressor proteins, as well as increased oncoprotein stabilization. The latter is due, in part, to mutation with
Externí odkaz:
https://doaj.org/article/51bd82036931426a95bb5b5f97a81875
Publikováno v:
Bio-Protocol, Vol 9, Iss 22 (2019)
Regulation of gene expression involves dynamic changes in chromatin organization, where in many cases open chromatin structure correlates with gene activation. Several methods enable monitoring changes in chromatin accessibility, including ATAC-seq,
Externí odkaz:
https://doaj.org/article/70a37fa24cc14f7ab1d7ae98f87d8780
Autor:
Naama Flint Brodsly, Eliya Bitman-Lotan, Olga Boico, Adi Shafat, Maria Monastirioti, Manfred Gessler, Christos Delidakis, Hector Rincon-Arano, Amir Orian
Publikováno v:
eLife, Vol 8 (2019)
The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises the identity of differentiated enterocytes (ECs) in the adult Drosophila midgut. Lineage tra
Externí odkaz:
https://doaj.org/article/01c984f6dcdf4551a99d8a95c4cf63fc
Autor:
Yifat Yanku, Eliya Bitman-Lotan, Yaniv Zohar, Estee Kurant, Norman Zilke, Martin Eilers, Amir Orian
Publikováno v:
Cells, Vol 7, Iss 10, p 151 (2018)
The HECT-type ubiquitin ligase HECT, UBA and WWE Domain Containing 1, (HUWE1) regulates key cancer-related pathways, including the Myc oncogene. It affects cell proliferation, stress and immune signaling, mitochondria homeostasis, and cell death. HUW
Externí odkaz:
https://doaj.org/article/675a75e8f41a44a49f9d7b6b72d0f6f6
Autor:
Michaela Reissland, Oliver Hartmann, Saskia Tauch, Cristian Prieto-Garcia, Clemens Schulte, Daniel Solvie, Sinah Loebbert, Anne-Claire Jacomin, Marina Pesic, Jeroen Bugter, Christina Schülein-Völk, Carmina Fuss, Nikolett Pahor, Carsten Ade, Viktoria Buck, Michael Potente, Vivian Li, Gerti Beliu, Armin Wiegering, Eliya Bitman-Lotan, Tom Grossmann, Mathias Rosenfeldt, Martin Eilers, Hans Maric, Madelon Maurice, Florian Greten, Ivan Dikic, Amir Oryan, Peter Gallant, Markus Diefenbacher
The contribution of deubiquitylating enzymes to β-Catenin stabilisation in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here, we report the deubiquitylase USP10 as an APC-truncation- specific enhancer of β-Catenin stabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cbc08d25e5786a9e89293d3727f74c9
https://doi.org/10.21203/rs.3.rs-2647009/v1
https://doi.org/10.21203/rs.3.rs-2647009/v1
Autor:
Michaela Reissland, Oliver Hartmann, Saskia Tauch, Cristian Prieto-Garcia, Clemens Schulte, Daniel Solvie, Sinah Loebbert, Anne-Claire Jacomin, Marina Pesic, Jeroen M. Bugter, Christina Schuelein-Voelk, Carmina T. Fuss, Nikolet Pahor, Carsten Ade, Viktoria Buck, Michael Potente, Vivian Li, Gerti Beliu, Armin Wiegering, Eliya Bitman-Lotan, Tom Grossmann, Mathias Rosenfeldt, Martin Eilers, Hans Maric, Madelon M. Maurice, Florian Greten, Ivan Dikič, Amir Orian, Peter Gallant, Markus E. Diefenbacher
SummaryThe contribution of deubiquitylating enzymes to β-Catenin stabilisation in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here, we report the deubiquitylase USP10 as an APC-truncation- specific enhancer of β-Catenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07cbccc13dc3cb445f4a5957beac5545
https://doi.org/10.1101/2023.02.10.527983
https://doi.org/10.1101/2023.02.10.527983
Autor:
Amir Orian, Eliya Bitman-Lotan
Publikováno v:
Cellular and Molecular Life Sciences
Regulation of the differentiated identity requires active and continued supervision. Inability to maintain the differentiated state is a hallmark of aging and aging-related disease. To maintain cellular identity, a network of nuclear regulators is de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37933515641ccb932ea03ffabbe2a175
http://europepmc.org/articles/PMC8038961
http://europepmc.org/articles/PMC8038961
Publikováno v:
Cells, Vol 10, Iss 2374, p 2374 (2021)
Cells
Cells
A hallmark of cancer is dysregulated protein turnover (proteostasis), which involves pathologic ubiquitin-dependent degradation of tumor suppressor proteins, as well as increased oncoprotein stabilization. The latter is due, in part, to mutation with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f8b77fcff54c504c420d5e201bcf04
https://www.mdpi.com/2073-4409/10/9/2374
https://www.mdpi.com/2073-4409/10/9/2374