Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eliver E.B. Ghosn"'
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105123- (2022)
Summary: Single-cell transcriptomics enables the definition of diverse human immune cell types across multiple tissues and disease contexts. Further deeper biological understanding requires comprehensive integration of multiple single-cell omics (tra
Externí odkaz:
https://doaj.org/article/372f05bd44cd4854825e14b536a1bcfb
Autor:
Debopam Ghosh, Tho D. Pham, Padma P. Nanaware, Deepanwita Sengupta, Lital N. Adler, Caiyun G. Li, Xiao He, Mary E. O'Mara, Aaron B. Kantor, Khoa D. Nguyen, Yang Yang, Laurence C. Eisenlohr, Peter E. Jensen, Leonore A. Herzenberg, Lawrence J. Stern, Scott D. Boyd, Eliver E.B. Ghosn, Elizabeth D. Mellins
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110200- (2022)
Summary: The non-classical Major Histocompatibility Complex class II (MHCII) protein, H2-M, edits peptides bound to conventional MHCII in favor of stable peptide/MHCII (p/MHCII) complexes. Here, we show that H2-M deficiency affects B-1 cell survival,
Externí odkaz:
https://doaj.org/article/bd96043bdd1c4fd6babe806d58bfbeb0
Stromal STAT5-mediated trophic activity regulates hematopoietic multipotent progenitor niche factors
Autor:
Zhengqi Wang, Grace Emmel, Hong Seo Lim, Wandi Zhu, Astrid Kosters, Eliver E.B. Ghosn, Peng Qiu, Kevin D. Bunting
Signal transducer and activator of transcription 5 (STAT5a and STAT5b) are intrinsically critical for normal hematopoiesis but are also expressed in stromal cells. Here, STAT5ab knockout (KO) was generated with a variety of bone marrow hematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5559f33b9237abcfb456687caaa37b1
https://doi.org/10.1101/2022.10.07.511255
https://doi.org/10.1101/2022.10.07.511255
Autor:
Zhihong Chen, Nishant Soni, Gonzalo Pinero, Bruno Giotti, Devon J. Eddins, Katherine E. Lindblad, James L Ross, Nadejda Tsankova, David H. Gutmann, Sergio A. Lira, Amaia Lujambio, Eliver E.B. Ghosn, Alexander M. Tsankov, Dolores Hambardzumyan
SUMMARYMyeloid cells comprise the majority of immune cells in tumors, contributing to tumor growth and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor driver mutation and therapeutic intervention impedes effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a59f3a1da663d4f8f758f9361091c0
https://doi.org/10.1101/2022.07.21.500690
https://doi.org/10.1101/2022.07.21.500690
Publikováno v:
The Journal of Immunology. 204:63.11-63.11
Tissue-resident macrophages (TRMΦ) are important immune sentinels responsible for maintaining tissue and immune homeostasis, where most develop during embryogenesis independently of long-term hematopoietic stem cells (LT-HSCs) and are maintained thr