Výsledky vyhledávání - "Elitza S. Sevova"

Cell-free Synthesis and Functional Characterization of Sphingolipid Synthases from Parasitic Trypanosomatid Protozoa

Autor: John Turk, Fong-Fu Hsu, James D. Bangs, Elitza S. Sevova, Kevin J. Schwartz, Michael A. Goren, Brian G. Fox

Publikováno v: Journal of Biological Chemistry. 285:20580-20587

The Trypanosoma brucei genome has four highly similar genes encoding sphingolipid synthases (TbSLS1-4). TbSLSs are polytopic membrane proteins that are essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bdab113f9a79b8e280c4c31ce5b14b
https://doi.org/10.1074/jbc.m110.127662

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Role of AP-1 in Developmentally Regulated Lysosomal Trafficking in Trypanosoma brucei

Autor: Kevin J. Schwartz, Jason S. Silverman, Elitza S. Sevova, James D. Bangs, Shaheen S. Sutterwala, Ngii N. Tazeh

Publikováno v: Eukaryotic Cell. 8:1352-1361

African trypanosomes are the causative agents of human trypanosomiasis (sleeping sickness). The pathogenic stage of the parasite has unique adaptations to life in the bloodstream of the mammalian host, including upregulation of endocytic and lysosoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896d40e6c0c742718095fa04499a2d47
https://doi.org/10.1128/ec.00156-09

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Developmentally regulated sphingolipid synthesis in African trypanosomes

Autor: Stephen M. Beverley, Fong-Fu Hsu, Phillip Key, Elitza S. Sevova, John Turk, Shaheen S. Sutterwala, James D. Bangs, Kevin J. Schwartz, Kai Zhang

Publikováno v: Molecular Microbiology. 70:281-296

Sphingolipids are essential components of eukaryotic membranes, and many unicellular eukaryotes, including kinetoplastid protozoa, are thought to synthesize exclusively inositol phosphorylceramide (IPC). Here we characterize sphingolipids from Trypan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80abbc95b5d52332be59dc784fa0706b
https://doi.org/10.1111/j.1365-2958.2008.06393.x

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Conserved residues in the Plasmodium vivax Duffy-binding protein ligand domain are critical for erythrocyte receptor recognition

Autor: John H. Adams, Kelley M. VanBuskirk, Elitza S. Sevova

Publikováno v: Proceedings of the National Academy of Sciences. 101:15754-15759

Malaria merozoite invasion of human erythrocytes depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium vivax merozoite invasion is totally dependent on the recognition of the Duffy blood group antigen by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744c32d6d417b299b17839ca5a154f3a
https://doi.org/10.1073/pnas.0405421101

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Streamlined Architecture and Glycosylphosphatidylinositol-dependent Trafficking in the Early Secretory Pathway of African Trypanosomes

Autor: James D. Bangs, Elitza S. Sevova

The variant surface glycoprotein (VSG) of bloodstream form Trypanosoma brucei (Tb) is a critical virulence factor. The VSG glycosylphosphatidylinositol (GPI)-anchor strongly influences passage through the early secretory pathway. Using a dominant-neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed8cf16959e9756a065f87d108a4a64
https://europepmc.org/articles/PMC2777104/

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