Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elitza Deltcheva"'
Autor:
Holly Simpson Ragdale, Melanie Clements, Wenhao Tang, Elitza Deltcheva, Catia Andreassi, Alvina G. Lai, Wai Hoong Chang, Maria Pandrea, Ivan Andrew, Laurence Game, Imran Uddin, Michael Ellis, Tariq Enver, Antonella Riccio, Samuel Marguerat, Simona Parrinello
Publikováno v:
Current Biology. 33:1082-1098.e8
Autor:
Masatake Araki, David C. Linch, Gillian May, Rachael Nimmo, P. Datta, Essam Ghazaly, Jane K. Howard, Graham M. Lord, J. Kasturiarachchi, Simon P. Brooks, Jamie Brown, Alan G. Marshall, Tariq Enver, Elitza Deltcheva, Asim Khwaja, Y. Guo, Nelomi Anandagoda, Chela James, Ian Jackson, Kimi Araki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Sladjana Gagrica, Simon Richardson, Jason Wray, Jyoti Bikram Chettri, Joost H.A. Martens, Anuradha Illendula, John H. Bushweller, Elitza Deltcheva, Yan-Ping Guo, Tariq Enver, Hendrik G. Stunnenberg, Rachael Nimmo, Charlotta Böiers
SummaryThe ETV6-RUNX1 onco-fusion arises in utero, initiating a clinically silent pre-leukemic state associated with the development of pediatric B-acute lymphoblastic leukemia (B-ALL). We characterize the ETV6-RUNX1 regulome by integrating chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cee28eace6b1c6895ce45cbfab03bc6
https://doi.org/10.1101/2020.12.22.423823
https://doi.org/10.1101/2020.12.22.423823
Autor:
Simon P. Brooks, J. Kasturiarachchi, Graham M. Lord, Jane K. Howard, Elitza Deltcheva, Asim Khwaja, David C. Linch, Tariq Enver, Kimi Araki, Rachael Nimmo, Alan G. Marshall, Nelomi Anandagoda, Chela James, P. Datta, Ian Jackson, Gillian May, Essam Ghazaly, Jamie Brown, Y. Guo, Masatake Araki
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
AML is a genetically heterogeneous disease and understanding how different co-occurring mutations cooperate to drive leukemogenesis will be crucial for improving diagnostic and therapeutic options for patients. MIR142 mutations have been recurrently
Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function
Autor:
John Brown, Shamit Soneji, Kenichi Miharada, Elitza Deltcheva, Els Mansell, Valgardur Sigurdsson, Tariq Enver, Jonas Larsson, Chela James
Publikováno v:
Cell Stem Cell. 28:241-256.e6
Summary Aging is associated with reduced fitness and increased myeloid bias of the hematopoietic stem cell (HSC) compartment, causing increased risk of immune compromise, anemia, and malignancy. We show that mitochondrial membrane potential (MMP) can
Autor:
Rachael Nimmo, Elitza Deltcheva
Publikováno v:
The Biochemical journal. 474(11)
The RUNX1 transcription factor is a critical regulator of normal haematopoiesis and its functional disruption by point mutations, deletions or translocations is a major causative factor leading to leukaemia. In the majority of cases, genetic changes
Autor:
Elitza Deltcheva, Anuradha Illendula, Jyoti Bikram Chettri, Chela James, Simon Richardson, John H. Bushweller, Rachael Nimmo, Charlotta Böiers, Jason Wray, Tariq Enver
Publikováno v:
Experimental Hematology. 76:S63
Leukaemia is the most common childhood cancer and acute lymphoblastic leukaemia (ALL) is responsible for a third of all childhood cancer deaths. Despite the overall good prognosis, failure to eradicate the disease leads to relapse in ∼20% of patien
Autor:
Tariq Enver, Elitza Deltcheva, Sten Eirik W. Jacobsen, Joe Harman, Emanuele Azzoni, Vincent Frontera, Marella F. T. R. de Bruijn, Chela James, John W. S. Brown
Publikováno v:
Experimental Hematology. 76:S57
Hematopoietic stem cells (HSCs) emerge from aortic hemogenic endothelium through a continuum of precursors, the pro- and pre-HSCs. Studies in zebrafish have implicated blood flow in this process. In the mouse, embryos without blood flow die before tr
Autor:
Emmanuelle Charpentier, Krzysztof Chylinski, Maria R. Eckert, Jörg Vogel, Zaid Ahmed Pirzada, Karine Gonzales, Elitza Deltcheva, Yanjie Chao, Cynthia M. Sharma
Publikováno v:
Nature
CRISPR/Cas systems constitute a widespread class of immunity systems that protect bacteria and archaea against phages and plasmids, and commonly use repeat/spacer-derived short crRNAs to silence foreign nucleic acids in a sequence-specific manner. Al