Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elissa Swearingen"'
Autor:
Jiamiao Lu, Elissa Swearingen, Miki Hardy, Patrick Collins, Bin Wu, Eric Yuan, Daniel Lu, Chi-Ming Li, Songli Wang, Michael Ollmann
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 423-434 (2022)
Small interfering RNA (siRNA) therapeutics have developed rapidly in recent years, despite the challenges associated with delivery of large, highly charged nucleic acids. Delivery of siRNA therapeutics to the liver has been established, with conjugat
Externí odkaz:
https://doaj.org/article/935d8624c35e4475a84459a08c7ac35c
Autor:
Karen Rex, Shawn Jeffries, Matthew L Brown, Timothy Carlson, Angela Coxon, Flordeliza Fajardo, Brendon Frank, Darin Gustin, Alexander Kamb, Paul D Kassner, Shyun Li, Yihong Li, Kurt Morgenstern, Matthew Plant, Kim Quon, Astrid Ruefli-Brasse, Joanna Schmidt, Elissa Swearingen, Nigel Walker, Zhulun Wang, J E Vivienne Watson, Dineli Wickramasinghe, Mariwil Wong, Guifen Xu, Holger Wesche
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68328 (2013)
Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen and potent chemoattractant, SPHK a
Externí odkaz:
https://doaj.org/article/dfda1f39979a456d9edd17f32579cba1
Autor:
Lei Liu, Jason Long, Ingrid C. Rulifson, Brad Herberich, Miki Hardy, Oliver Homann, Monica Florio, Mei-Chu Lo, Jerry Ryan Holder, Shivani Singh, Hui Dou, Michael Ollmann, Elissa Swearingen, Danielle Pruitt, Kelvin K. C. Sham, Bin Wu, Justin K. Murray, Artem Shkumatov
Publikováno v:
Nucleic Acid Therapeutics. 31:324-340
Human genome wide association studies confirm the association of the rs738409 single nucleotide polymorphism (SNP) in the gene encoding protein patatin like phospholipase domain containing 3 (PNPLA...
Publikováno v:
SLAS Discovery. 8:198-204
A generic high-throughput screening assay based on the scintillation proximity assay technology has been developed for protein kinases. In this assay, the biotinylated (33)P-peptide product is captured onto polylysine Ysi bead via avidin. The scintil
Autor:
Olivier Nolan-Stevaux, Mariana Pfreimer, Peter Jaeckel, Wendy Zhong, Astrid Ruefli-Brasse, Vivienne J. Watson, Elissa Swearingen, Elissa Cosgrove, Silvia Materna-Reichelt, Holger Beckmann, Mike Ollmann, Paul D. Kassner, Jayee Banerjee
Publikováno v:
Cancer Research. 76:4548-4548
USP8 and the ESCRT pathway (endosomal sorting complex required for transport) are required for cellular homeostasis through key functions in shuttling ubiquitinated proteins towards lysosomal degradation, and through regulating the maturation of auto
Autor:
Timothy J. Carlson, Astrid Ruefli-Brasse, Elissa Swearingen, Darin J. Gustin, Matthew L. Brown, Paul D. Kassner, Joanna Schmidt, Mariwil Wong, Matthew H. Plant, Karen Rex, Flordeliza Fajardo, Alexander Kamb, Shawn M. Jeffries, Kim Quon, Dineli Wickramasinghe, Zhulun Wang, Shyun Li, Angela Coxon, Yihong Li, Kurt Morgenstern, J. E. Vivienne Watson, Nigel Walker, Brendon Frank, Holger Wesche, Guifen Xu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e68328 (2013)
PLoS ONE, Vol 8, Iss 7, p e68328 (2013)
Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen and potent chemoattractant, SPHK a
Autor:
Astrid A. Ruefli-Brasse, Cynthia Hart, Liza Fajardo, Elissa Swearingen, Linda Wong, Doreen Sakamoto, Kari Hale, Huanying Ge, Jeffery McDowell, Bharath Ramachandran, Elissa Cosgrove, J.E.Vivienne Watson, Seamus Ragan, Paul Kassner, Kim Quon
Publikováno v:
Cancer Research. 73:2992-2992
The interpretation of RNAi knockdown experiments can be challenging due to the extensive off-target effects exhibited by siRNAs and shRNAs. This has led to the reporting of results that cannot be independently verified, or to the identification of pu