Early impairment of thalamocortical circuit activity and coherence in a mouse model of Huntington's disease

Autor: Justin L. Shobe, Elissa J. Donzis, Kwang Lee, Samiksha Chopra, Sotiris C. Masmanidis, Carlos Cepeda, Michael S. Levine

Publikováno v: Neurobiology of Disease, Vol 157, Iss , Pp 105447- (2021)

Huntington's disease (HD) is a progressive, fatal neurodegenerative disorder characterized by motor, cognitive, and psychiatric disturbances. There is no known cure for HD, but its progressive nature allows for early therapeutic intervention. Current

Externí odkaz: https://doaj.org/article/23018235b2024f95bbe738d7aa2c872f

Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke

Autor: Ana María Estrada-Sánchez, Elissa J. Donzis, Michael Levine, S. Thomas Carmichael, Rouhollah Habibey, H Rezaei Nejad, Peyman Golshani, Simon Mitchell, Shahrzad Latifi, F. Hosseini

Publikováno v: Cerebral cortex (New York, N.Y. : 1991), vol 30, iss 12
Cereb Cortex

Despite substantial recent progress in network neuroscience, the impact of stroke on the distinct features of reorganizing neuronal networks during recovery has not been defined. Using a functional connections-based approach through 2-photon in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc2fe9a29e2aa51b2507aaaa1cf0bd2
https://escholarship.org/uc/item/0xq5h214

Neurophysiological Assessment of Huntington's Disease Model Mice

Autor: Elissa J, Donzis, Sandra M, Holley, Carlos, Cepeda, Michael S, Levine

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1780

Electrophysiological and cell imaging techniques are powerful tools for understanding alterations in neuronal activity in Huntington's disease (HD), a fatal neurological disorder caused by an expansion of CAG repeats in the HTT gene. Changes in neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7978decda9f152cac89e1328c0cb5449
https://pubmed.ncbi.nlm.nih.gov/29856019

Quantitative Electroencephalographic Biomarkers in Preclinical and Human Studies of Huntington’s Disease: Are They Fit-for-Purpose for Treatment Development?

Autor: Elissa J. Donzis, Michael S. Levine, Aimee M. Hunter, Michael K. Leuchter, Ian A. Cook, Carlos Cepeda, Andrew F. Leuchter, Ana María Estrada-Sánchez

Publikováno v: Frontiers in Neurology
Leuchter, MK; Donzis, EJ; Cepeda, C; Hunter, AM; Estrada-Sánchez, AM; Cook, IA; et al.(2017). Quantitative electroencephalographic biomarkers in preclinical and human studies of Huntington's disease: Are they fit-for-purpose for treatment development?. Frontiers in Neurology, 8(MAR). doi: 10.3389/fneur.2017.00091. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0tb9k5qb
Frontiers in neurology, vol 8, iss MAR

© 2017 Leuchter, Donzis, Cepeda, Hunter, Estrada-Sánchez, Cook, Levine and Leuchter. A major focus in development of novel therapies for Huntington's disease (HD) is identification of treatments that reduce the burden of mutant huntingtin (mHTT) pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d79c0ebb7944460e1b7d735b22444e
https://doi.org/10.3389/fneur.2017.00091

Inhibition of mTOR Activity Restores Tamoxifen Response in Breast Cancer Cells with Aberrant Akt Activity

Autor: Jessica M. Silva, Richard A. Roth, William E. Friedrichs, Linda A. deGraffenried, Manuel Hidalgo, Douglas H. Russell, Amanda K. Middleton, Elissa J. Donzis

Publikováno v: Clinical Cancer Research. 10:8059-8067

The Akt kinase is a serine/threonine protein kinase that has been implicated in mediating a variety of biological responses. Studies show that high Akt activity in breast carcinoma is associated with a poor pathophenotype, as well as hormone and chem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6611835ccf1445a244dad02590113c
https://doi.org/10.1158/1078-0432.ccr-04-0035