Výsledky vyhledávání - "Elissa B Dodd-Eaton"

Data from Penetrance Estimates Over Time to First and Second Primary Cancer Diagnosis in Families with Li-Fraumeni Syndrome: A Single Institution Perspective

Autor: Wenyi Wang, Louise C. Strong, Jing Ning, Christopher I. Amos, Xianhua Kong, Jingxiao Chen, Jasmina Bojadzieva, Fan Gao, Elissa B. Dodd-Eaton, Seung Jun Shin

Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder associated with TP53 germline mutations and an increased lifetime risk of multiple primary cancers (MPC). Penetrance estimation of time to first and second primary cancer within LFS rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab064eb205777831f540711a870ea1e
https://doi.org/10.1158/0008-5472.c.6512032.v1

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Personalized Risk Prediction for Cancer Survivors: A Bayesian Semi-parametric Recurrent Event Model with Competing Outcomes

Autor: Nam H Nguyen, Seung Jun Shin, Elissa B Dodd-Eaton, Jing Ning, Wenyi Wang

Multiple primary cancers are increasingly more frequent due to improved survival of cancer patients. Characteristics of the first primary cancer largely impact the risk of developing subsequent primary cancers. Hence, model-based risk characterizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f58fbc354551f8f83e20b9fea25f3b28
https://doi.org/10.1101/2023.02.28.530537

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Abstract 5761: Bayesian estimation of a semi-parametric recurrent event model with competing outcomes for personalized risk prediction among cancer survivors

Autor: Nam H. Nguyen, Elissa B. Dodd-Eaton, Seung Jun Shin, Jing Ning, Wenyi Wang

Publikováno v: Cancer Research. 83:5761-5761

Multiple primary cancer (MPC) is becoming more common in the general population, accounting for approximately 20% of incidence cases in the United States. Epidemiological studies indicate a strong dependence of the subsequent primary on the character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfdb86185aaaae145d99df1b09da2fd5
https://doi.org/10.1158/1538-7445.am2023-5761

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Abstract 5240: Validation of research cohort based penetrance estimates for multiple cancer types and multiple primary cancers on clinically ascertained families

Autor: Nam H. Nguyen, Elissa B. Dodd-Eaton, Jessica L. Corredor, Jacynda Woodman-Ross, Nathaniel D. Hernandez, Angelica M. Gutierrez Barrera, Banu K. Arun, Wenyi Wang

Publikováno v: Cancer Research. 83:5240-5240

Age-at-onset penetrance is the probability of developing disease by a certain age given a patient’s characteristics. Accurate penetrance estimates are important for cancer screening and diagnosis, and for policy making in public health. We develope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66eb0521db827d1c81555846139539d4
https://doi.org/10.1158/1538-7445.am2023-5240

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Penetrance Estimates Over Time to First and Second Primary Cancer Diagnosis in Families with Li-Fraumeni Syndrome: A Single Institution Perspective

Autor: Louise C. Strong, Christopher I. Amos, Elissa B. Dodd-Eaton, Jingxiao Chen, Wenyi Wang, Jing Ning, Jasmina Bojadzieva, Fan Gao, Xianhua Kong, Seung Jun Shin

Publikováno v: Cancer Res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4879382bc2bbe4b8656d95cdd290b37
https://doi.org/10.1158/0008-5472.can-19-0725

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Penetrance of Different Cancer Types in Families with Li-Fraumeni Syndrome: A Validation Study Using Multicenter Cohorts

Autor: Elissa B. Dodd-Eaton, Ying Yuan, Jasmina Bojadzieva, Phuong L. Mai, Megan N. Frone, Sharon A. Savage, Mandy L. Ballinger, Louise C. Strong, Jingxiao Chen, Seung Jun Shin, Wenyi Wang, Payal P. Khincha, Gang Peng, Christopher I. Amos, David Thomas

Publikováno v: Cancer Research. 80:354-360

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an autosomal-dominant mutation inheritance in the TP53 tumor suppressor gene and a wide spectrum of cancer diagnoses. The previously developed R package, LFSPRO, is capab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89ea6666106dfbfd9279847fd76d6656
https://doi.org/10.1158/0008-5472.can-19-0728

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Determining concordance of LFSPRO TP53 germline carrier risk predictions to standard genetic counseling practice

Autor: Elissa B. Dodd-Eaton, Hoai Nam Nguyen, Jessica Corredor, Jacynda Woodman-Ross, Gang Peng, Sierra Green, Nathaniel D. Hernandez, Angelica Gutierrez Barrera, Banu Arun, Wenyi Wang

Publikováno v: Journal of Clinical Oncology. 40:10593-10593

10593 Background: Li-Fraumeni Syndrome (LFS) is a hereditary cancer syndrome associated with a germline mutation in the TP53 tumor suppressor gene and an increased risk of developing a spectrum of cancers throughout a carrier’s lifetime. Early canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ca263d8e3088f37ffc9d45d1a7f8931
https://doi.org/10.1200/jco.2022.40.16_suppl.10593

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A pedigree-based prediction model identifies carriers of deleterious de novo mutations in families with Li-Fraumeni syndrome

Autor: Phuong L. Mai, Danielle Braun, Valen E. Johnson, Matthew D. Montierth, Jasmina Bojadzieva, Kristin Zelley, Carlos Christian Vera Recio, Elissa B. Dodd-Eaton, Louise C. Strong, Fan Gao, Wenyi Wang, Judy Garber, Xuedong Pan, Sharon A. Savage, Kim E. Nichols

Publikováno v: Genome Res

De novo mutations (DNMs) are increasingly recognized as rare disease causal factors. Identifying DNM carriers will allow researchers to study the likely distinct molecular mechanisms of DNMs. We developed Famdenovo to predict DNM status (DNM or famil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c033edb8a0b62093c872bf57e82ed8
https://pubmed.ncbi.nlm.nih.gov/32817165

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