Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elissa A. Fink"'
Autor:
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth, Brian K. Shoichet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostagl
Externí odkaz:
https://doaj.org/article/5afef5b1703241589164379113e645d4
Autor:
Elissa A. Fink, Jun Xu, Harald Hübner, Joao M. Braz, Philipp Seemann, Charlotte Avet, Veronica Craik, Dorothee Weikert, Maximilian F. Schmidt, Chase M. Webb, Nataliya A. Tolmachova, Yurii S. Moroz, Xi-Ping Huang, Chakrapani Kalyanaraman, Stefan Gahbauer, Geng Chen, Zheng Liu, Matthew P. Jacobson, John J. Irwin, Michel Bouvier, Yang Du, Brian K. Shoichet, Allan I. Basbaum, Peter Gmeiner
Publikováno v:
Science. 377
Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α 2A -adrenergic receptor (α 2A AR), seeking new α 2A AR agonists chemotypes that lack the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d0d773df6654433617ced8c92103ff
https://doi.org/10.1126/science.abn7065
https://doi.org/10.1126/science.abn7065
Autor:
Elissa A. Fink, Conner Bardine, Stefan Gahbauer, Isha Singh, Kris White, Shuo Gu, Xiaobo Wan, Beatrice Ary, Isabella Glenn, Joseph O’Connell, Henry O’Donnell, Pavla Fajtová, Jiankun Lyu, Seth Vigneron, Nicholas J. Young, Ivan S. Kondratov, Anthony J. O’Donoghue, Yurii Moroz, Jack Taunton, Adam R. Renslo, John J. Irwin, Adolfo García-Sastre, Brian K. Shoichet, Charles S. Craik
Antiviral therapeutics to treat SARS-CoV-2 are much desired for the on-going pandemic. A well-precedented viral enzyme is the main protease (MPro), which is now targeted by an approved drug and by several investigational drugs. With the inevitable li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a54cce0adbd99c2d1934399aea5fb9c
https://doi.org/10.1101/2022.07.05.498881
https://doi.org/10.1101/2022.07.05.498881
Autor:
Leila Peraro, Sigrid Carle, Xiaoyu Zang, Heli K. Shah, Ryan T. Davison, Travis R. Blum, David J. Slade, Deepak Vallabhaneni, Caitlyn E. Fennell, Kathryn E. Cole, Matthew R. Burnett, Justin S. Miller, Deirdre M. Wholly, Kathryn M. Ingalls, Jacob T. Sivak, Vernon E. Lawson, Elissa A. Fink, Stephanie L. Cramer, Chelsea T. Herr
Publikováno v:
The Journal of Organic Chemistry. 85:8253-8260
We describe the synthesis of Xyzidepsin, a depsipeptidic analogue of HDAC inhibitor Romidepsin (FK228), using a solid-phase strategy. Our latent thioester solid-phase linker was synthesized in 92% yield (three steps). Chemoselective conditions unmask
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d336d3c2d41912dc2b9df760e904381
https://doi.org/10.1021/acs.joc.0c00854
https://doi.org/10.1021/acs.joc.0c00854
Autor:
John J. Irwin, Stefan Gahbauer, Brian K. Shoichet, Elissa A Fink, Andreas Luttens, Chase M Webb, Jens Carlsson, Trent E. Balius, Reed M. Stein, Jiankun Lyu, Brian J. Bender
Publikováno v:
Nature protocols, vol 16, iss 10
Nature Protocols
Nat Protoc
Nature Protocols
Nat Protoc
Structure-based docking screens of large compound libraries have become common in early drug and probe discovery. As computer efficiency has improved and compound libraries have grown, the ability to screen hundreds of millions, and even billions, of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a64d6d4f3dbd3694374d6452f510ec
https://escholarship.org/uc/item/9hs932s0
https://escholarship.org/uc/item/9hs932s0
Autor:
Zun Zar Chi Naing, Maru Jaime-Garza, Taia S. Wu, Laurel S Estes, Martin Kampmann, Eric D. Chow, Taylor B. Cavazos, Miriam A. Goldman, Yessica K. Gomez, William F. DeGrado, Stephanie A. Wankowicz, Matthew C. Johnson, Christa Caggiano, Christina A. Stephens, Bryan Faust, Daniel Barrero, Lakshmi E. Miller-Vedam, Elizabeth E. McCarthy, Kyle E. Lopez, Sy Redding, Jenna Pellegrino, Elissa A Fink, Wren Saylor, Alison M Maxwell, Hayarpi Torosyan, Jared Lumpe, Robert W. Newberry, George C. Hartoularos, Daniel M. C. Schwarz, Calla Martyn, Laura M. Gunsalus, Jack Strickland, Maureen Pittman, Taylor Arhar, Andrew F. Kung, Daniel R. Wong, Garrett Wong, Nishith R. Reddy, Matthew G. Jones, Aji Palar, Erik J. Navarro, Nick Hoppe, M. Grace Gordon, Douglas R. Wassarman, Jean Costello, Adam Catching
Publikováno v:
ACS Chem Biol
ACS chemical biology, vol 15, iss 8
ACS chemical biology, vol 15, iss 8
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8292e5bf8e0f1174d79b4faba3fc334b
Autor:
Brian J. Bender, Stefan Gahbauer, Andreas Luttens, Jiankun Lyu, Chase M. Webb, Reed M. Stein, Elissa A. Fink, Trent E. Balius, Jens Carlsson, John J. Irwin, Brian K. Shoichet
Publikováno v:
Nature Protocols. 17:177-177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86560bfaa1ca5b3d20a03464f500007
https://doi.org/10.1038/s41596-021-00650-x
https://doi.org/10.1038/s41596-021-00650-x