Drug resistance of cancer cells is crucially affected by expression levels of ABC-transporters

Autor: Petr Mlejnek, Petr Dolezel, Eliska Ruzickova

Publikováno v: BioDiscovery, Vol 20, Iss , Pp 1-13 (2017)

Dasatinib (DAS), a second generation of tyrosine kinase inhibitor (TKI), represents excellent choice for the treatment of chronic myeloid leukemia resistant to imatinib. Unfortunately, recent laboratory studies suggested that antiproliferative effect

Externí odkaz: https://doaj.org/article/7f828382aaac4306b406d719871240eb

Reversal of ABCB1 mediated efflux by imatinib and nilotinib in cells expressing various transporter levels

Autor: Eliska Ruzickova, Susan E. Bates, Petr Kosztyu, Petr Dolezel, Petr Mlejnek

Publikováno v: Chemico-Biological Interactions. 273:171-179

Recently, it has been suggested that imatinib (IM) and nilotinib (NIL) could be studied beyond their original application, as inhibitors of the drug efflux pump ABCB1 (P-glycoprotein, MDR1). Since the reversal of ABCB1-mediated resistance has never b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4184c44b4d7f6e33ee58b69cbf0e8efd
https://doi.org/10.1016/j.cbi.2017.06.012

Apoptosis Induced by the Curcumin Analogue EF-24 Is Neither Mediated by Oxidative Stress-Related Mechanisms nor Affected by Expression of Main Drug Transporters ABCB1 and ABCG2 in Human Leukemia Cells

Autor: Petr Dolezel, Eliska Ruzickova, Nikola Skoupa, Petr Mlejnek

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 11, p 2289 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2289

The synthetic curcumin analogue, 3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone (EF-24), suppresses NF-κB activity and exhibits antiproliferative effects against a variety of cancer cells in vitro. Recently, it was reported that EF-24-induced apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925742af84ff446eb727e53593f03277
http://europepmc.org/articles/PMC5713259

Drug resistance of cancer cells is crucially affected by expression levels of ABC-transporters

Autor: Eliska Ruzickova, Petr Mlejnek, Petr Dolezel

Publikováno v: BioDiscovery, Vol 20, Iss, Pp 1-13 (2017)
BioDiscovery 20: e11211

Dasatinib (DAS), a second generation of tyrosine kinase inhibitor (TKI), represents excellent choice for the treatment of chronic myeloid leukemia resistant to imatinib. Unfortunately, recent laboratory studies suggested that antiproliferative effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a739b680efdf073b30351a06225d8c22
https://doi.org/10.3897/biodiscovery.20.e11211