Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Elisia, Villemure"'
Autor:
Luiz F. T. Novaes, Justin S. K. Ho, Kaining Mao, Kaida Liu, Mayank Tanwar, Matthew Neurock, Elisia Villemure, Jack A. Terrett, Song Lin
Publikováno v:
Journal of the American Chemical Society. 144:1187-1197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a54585b9021d1767e1818900bed6ce74
https://doi.org/10.1021/jacs.1c09412
https://doi.org/10.1021/jacs.1c09412
Autor:
Martin Dery, Huifen Chen, Shannon D. Shields, Elisia Villemure, Robin Larouche-Gauthier, Rebecca M. Reese, Jack A. Terrett, Matthew Volgraf, Jun Chen, Steven Magnuson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Transient receptor potential ankyrin 1 (TRPA1) antagonists have generated broad interest in the pharmaceutical industry for the treatment of both pain and asthma. Over the past decade, multiple antagonist classes have been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577568716436f8ad375243faf967e8af
https://doi.org/10.1021/acsmedchemlett.1c00305
https://doi.org/10.1021/acsmedchemlett.1c00305
Autor:
Jun Chen, Baihua Hu, Kevin M. Johnson, Kang-Jye Chou, Jack A. Terrett, Yunli Wang, Lea Constantineau-Forget, Steven Magnuson, Chantal Grand-Maître, Francis Beaumier, John Liu, Lorena Riol-Blanco, Shannon D. Shields, Yong Chen, Brian Safina, Martin Dery, Elisia Villemure, Claudio Sturino, Huifen Chen, Luce Lépissier, Matthew Volgraf, Alessia Balestrini, Xiumin Wu, Daniel G. Shore, Stuart Ward, Wyne P. Lee, David H. Hackos, Andrew Peter Cridland, Robin Larouche-Gauthier, Lionel Rouge, Stephane Ciblat, Aijun Lu, Matt Baumgardner, Justin Ly, Rebecca M. Reese, Alexis Rohou, Eric Suto, Juan Zhang, Hank La
Publikováno v:
Journal of Medicinal Chemistry. 64:3843-3869
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespread interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17e5be6b310c8cbde93a6ecff3b6232
https://doi.org/10.1021/acs.jmedchem.0c02023
https://doi.org/10.1021/acs.jmedchem.0c02023
Publikováno v:
Journal of Medicinal Chemistry. 63:7957-7985
The ubiquitin proteasome system (UPS) presents many opportunities for pharmacological intervention. Key players in the UPS are E3 ubiquitin ligases, responsible for conjugation of ubiquitin to specific cognate substrates. Numbering more than 600 memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe5d7e4de24ed0f9b95c65a17615ffa
https://doi.org/10.1021/acs.jmedchem.9b01451
https://doi.org/10.1021/acs.jmedchem.9b01451
Autor:
Luiz F T, Novaes, Justin S K, Ho, Kaining, Mao, Kaida, Liu, Mayank, Tanwar, Matthew, Neurock, Elisia, Villemure, Jack A, Terrett, Song, Lin
Publikováno v:
Journal of the American Chemical Society. 144(3)
The "magic methyl" effect, a dramatic boost in the potency of biologically active compounds from the incorporation of a single methyl group, provides a simple yet powerful strategy employed by medicinal chemists in the drug discovery process. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3010c194be095acb8bcfe0c065290d5
https://pubmed.ncbi.nlm.nih.gov/35015533
https://pubmed.ncbi.nlm.nih.gov/35015533
Autor:
Matthew Neurock, Kaida Liu, Luiz F. T. Novaes, Song Lin, Kaining Mao, Mayank Tanwar, Elisia Villemure, Justin Ho, Jack A. Terrett
The “magic methyl” effect – a dramatic boost in the potency of biologically active compounds from the incorporation of a single methyl group – provides a simple yet powerful strategy employed by medicinal chemists in the drug discovery proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063e80101599acffba81f28b6e0b2de2
https://doi.org/10.33774/chemrxiv-2021-65lhz-v2
https://doi.org/10.33774/chemrxiv-2021-65lhz-v2
Autor:
Wienke Lange, Tianbo Li, Jun Chen, Eleonora Gianti, Elisia Villemure, Matthew Volgraf, Elisa Ballini, Steven Magnuson, Heike Deisemann, Tania Chernov-Rogan, Stuart Ward, Chang Liu, Andrew Peter Cridland, Vincenzo Carnevale, Xiaoyu Hu, Brian Safina, Michael L. Klein, David H. Hackos
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The TRPA1 channel functions as an irritant sensor and is a therapeutic target for treating pain, itch, and respiratory diseases. TRPA1 can be activated by electrophilic compounds via covalent modification or activated by noncovalent agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a373c57d25cc26383c64d16e334f0c5e
https://doi.org/10.1073/pnas.1913929116
https://doi.org/10.1073/pnas.1913929116
Autor:
Jun Chen, Justin Elstrott, Lan Wang, Simon S. Gao, Richard A.D. Carano, Jose E. Heredia, Elisia Villemure, Daniel G. Shore, Wyne P. Lee, Bobby Brillantes, Joseph H. Lin, Liling Liu, David H. Hackos, Jens Kortmann, Matthew Volgraf, Daniel D. Bravo, Christine Tam, Lorena Riol-Blanco, Steven Magnuson, Lionel Rouge, Chris Bjornson, Baihua Hu, Tania Chernov-Rogan, Rebecca M. Reese, Christopher P. Arthur, Min Jung, Michelle Dourado, Xiumin Wu, Victory Joseph, Alberto Estevez, John Liu, Alvin Gogineni, Juan Zhang, Laurie Leong, Jian Payandeh, Vishal Verma, Shannon D. Shields, Han Ting Ding, Brian Safina, Alessia Balestrini, Yong Chen, Vineela D. Gandham, Eric Suto, Jianyong Wang, Justin Ly, Rebecca N. Bauer, Jonas Doerr, Alexis Rohou, Cary D. Austin, Jason A. Vander Heiden, Xiaoying Yang, Ryan L. Wong, Lucinda Tam, Liuxi Chen, Kathy Hötzel, Kai H. Barck, Merone Roose-Girma, Claudio Ciferri, Huifen Chen, Bianca M. Liederer
Publikováno v:
Journal of Experimental Medicine. 218
Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7586a7b163f0274f73ff2d6634f422f1
https://doi.org/10.1084/jem.20201637
https://doi.org/10.1084/jem.20201637
Autor:
Mingcui Liu, Aijun Lu, Shun Zhang, Heidi J.A. Wallweber, Matthew Volgraf, Bianca M. Liederer, David H. Hackos, Jacob Schwarz, Yuen Po-Wai, Elisia Villemure, Gauri Deshmukh, Xifeng Luo, Benjamin D. Sellers, Jesse E. Hanson, Tzu-Ming Wang, Jiang Yu, Kimberly Scearce-Levie, Cuong Ly, Guosheng Wu, Emile Plise, Suzanne Tay, Patrick J. Lupardus
Publikováno v:
ACS Medicinal Chemistry Letters. 8:84-89
The N-methyl-d-aspartate receptor (NMDAR) is an ionotropic glutamate receptor, gated by the endogenous coagonists glutamate and glycine, permeable to Ca2+ and Na+. NMDAR dysfunction is associated with numerous neurological and psychiatric disorders,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fe9a055cda826976286bf243f7a420a
https://doi.org/10.1021/acsmedchemlett.6b00388
https://doi.org/10.1021/acsmedchemlett.6b00388
Autor:
Rebecca M. Reese, Desiree Amm, Justin Ly, Aleksandr Kolesnikov, Christine E. Brotherton-Pleiss, Steven Do, Daniel G. Shore, David H. Hackos, Vishal Verma, Matthew Volgraf, Lesley J. Murray, Xiaofeng Xu, Guosheng Wu, Aijun Lu, Jun Chen, Baihua Hu, Martin E. Dahl, Huifen Chen, Yuen Po-Wai, Elisia Villemure, Yamin Zhang, Joseph P. Lyssikatos, Yong Chen, Brian Safina, Lan Wang, Anthony Estrada, Wienke Lange, Shawn David Erickson, Shannon D. Shields, Suzanne Tay
Publikováno v:
Journal of medicinal chemistry. 61(8)
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a plethora of electrophilic compounds and is implicated in pain, itch, and respiratory disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1efb169a4638458b259af0587c1a4d5
https://pubmed.ncbi.nlm.nih.gov/29590749
https://pubmed.ncbi.nlm.nih.gov/29590749