Výsledky vyhledávání - "Elisiário Tavares da Silva"

Akademický článek

Apoptosis and autophagy in breast cancer cells following exemestane treatment.

Autor: Cristina Amaral, Margarida Borges, Soraia Melo, Elisiário Tavares da Silva, Georgina Correia-da-Silva, Natércia Teixeira

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42398 (2012)

Aromatase inhibitors (AIs), which block the conversion of androgens to estrogens, are used for hormone-dependent breast cancer treatment. Exemestane, a steroidal that belongs to the third-generation of AIs, is a mechanism-based inhibitor that binds c

Externí odkaz: https://doaj.org/article/4d3bbfecb5714b93a74de20f12261c29

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Akademický článek

An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER+) Breast Cancer: Effects on Sensitive and Resistant Cell Lines

Autor: Cristina Amaral, Georgina Correia-da-Silva, Cristina Ferreira Almeida, Maria João Valente, Carla Varela, Elisiário Tavares-da-Silva, Anne Marie Vinggaard, Natércia Teixeira, Fernanda M. F. Roleira

Publikováno v: Molecules, Vol 28, Iss 2, p 789 (2023)

Around 70–85% of all breast cancer (BC) cases are estrogen receptor-positive (ER+). The third generation of aromatase inhibitors (AIs) is the first-line treatment option for these tumors. Despite their therapeutic success, they induce several side

Externí odkaz: https://doaj.org/article/2a713d38283d4b21866579952abfa3f7

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The Structural Diversity and Biological Activity of Steroid Oximes

Autor: Elisiário Tavares da Silva, Ana Rita Gomes, Salomé Pires, Fernanda Roleira

Publikováno v: Molecules. 28:1690

Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included. Oximes are a chemical group with the general formula R1R2C=N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::203c2eb1388d2308df1dd15d2351d92e
https://doi.org/10.3390/molecules28041690

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