Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elisha Segrist"'
Publikováno v:
PLoS Pathogens, Vol 20, Iss 11, p e1012672 (2024)
All organisms sense and respond to pathogenic challenge. Tissue-specific responses are required to combat pathogens infecting distinct cell types. Cyclic dinucleotides (CDNs) are produced endogenously downstream of pathogen recognition or by pathogen
Externí odkaz:
https://doaj.org/article/4ed88ee325cd4d29a6c963e5803f8b6f
Autor:
Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Elisha Segrist, Minghua Li, Brinda Kamalia, Lauren Castellana, Kasirajan Ayyanathan, Fabian L. Cardenas-Diaz, Edward E. Morrisey, Rachel Truitt, Wenli Yang, Kellie Jurado, Kirandeep Samby, Holly Ramage, David C. Schultz, Sara Cherry
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108959- (2021)
Summary: There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of ∼3,000 drugs. Screening in Vero cells finds few
Externí odkaz:
https://doaj.org/article/8f60a618f20a43da8cfde02376a0da5e
Autor:
Brent A. Hackett, Mark Dittmar, Elisha Segrist, Nathan Pittenger, Julie To, Trevor Griesman, Beth Gordesky-Gold, David C. Schultz, Sara Cherry
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Arthropod-borne viruses are diverse pathogens and are often associated with human disease. These viruses span multiple genera, including flaviviruses, alphaviruses, and bunyaviruses. In a high-throughput drug screen, we found that tenovin-1
Externí odkaz:
https://doaj.org/article/443ecdb4a429445e8eefee560540f5c9
Autor:
Elisha Segrist, Sara Cherry
Publikováno v:
Immunity. 55:1581-1583
Tumors can cause wasting and mortality, but the connection between these outcomes is unclear. In this issue of Immunity, Chen and colleagues find the outcomes are separable as the tumor-altered gut microbiota activates renal immunity and alters metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d606a48c5fc3ce8f2005f5319a976f33
https://doi.org/10.1016/j.immuni.2022.08.011
https://doi.org/10.1016/j.immuni.2022.08.011
Publikováno v:
Cell Rep
Enteric pathogens overcome barrier immunity within the intestinal environment that includes the endogenous flora. The microbiota produces diverse ligands, and the full spectrum of microbial products that are sensed by the epithelium and prime protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50201a79457dd0107ca8957ac6d63b11
https://pubmed.ncbi.nlm.nih.gov/34965418
https://pubmed.ncbi.nlm.nih.gov/34965418
Autor:
Kanupriya Whig, Jae Seung Lee, Sara Cherry, Minghua Li, Kirandeep Samby, Kellie A. Jurado, Elisha Segrist, Holly Ramage, David C. Schultz, Mark Dittmar
The novel coronavirus SARS-CoV-2 emerged in China at the end of 2019 and rapidly became a global pandemic. While there are a variety of experimental treatments currently in clinical trials, there is a dearth of approved therapeutics to treat COVID-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71410abbc2667fce4cf40f34776f4744
https://doi.org/10.1101/2020.06.19.161042
https://doi.org/10.1101/2020.06.19.161042
Autor:
Elisha Segrist, Sara Cherry
Publikováno v:
Cell Host Microbe
The intestine is an essential physical and immunological barrier comprised of a monolayer of diverse and specialized epithelial cells that perform functions ranging from nutrient absorption to pathogen sensing and intestinal homeostasis. The intestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917c4f16d47e1310ee7632e1127bb6fd
https://europepmc.org/articles/PMC7735531/
https://europepmc.org/articles/PMC7735531/
Autor:
Mark Dittmar, Elisha Segrist, Trevor Griesman, Julie To, Beth Gordesky-Gold, David C. Schultz, Sara Cherry, Nathan Pittenger, Brent A. Hackett
Publikováno v:
mBio, Vol 10, Iss 4, p e01446-19 (2019)
mBio
mBio, Vol 10, Iss 4 (2019)
mBio
mBio, Vol 10, Iss 4 (2019)
Arthropod-borne viruses are diverse pathogens and are associated with human disease. Through high-throughput drug screening, we found that sirtuin inhibitors are potently antiviral against diverse arboviruses, including flaviviruses such as West Nile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e70979332548bc58316025e0305e08
https://doaj.org/article/4aa1eef6e4a44620837176c62f3f47d2
https://doaj.org/article/4aa1eef6e4a44620837176c62f3f47d2
Autor:
Edward E. Morrisey, Lauren Castellana, Wenli Yang, Kanupriya Whig, Elisha Segrist, Kellie A. Jurado, Kasirajan Ayyanathan, David C. Schultz, Holly Ramage, Sara Cherry, Brinda Kamalia, Kirandeep Samby, Minghua Li, Fabian L. Cardenas-Diaz, Mark Dittmar, Rachel Truitt, Jae Seung Lee
Publikováno v:
Cell Reports
Cell Reports, Vol 35, Iss 1, Pp 108959-(2021)
Cell Reports, Vol 35, Iss 1, Pp 108959-(2021)
There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of ∼3,000 drugs. Screening in Vero cells finds few antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d878e7c1932c8dc97a98493c5a4853
http://europepmc.org/articles/PMC7985926
http://europepmc.org/articles/PMC7985926