Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Eliseo Papa"'
Autor:
Anna Gogleva, Dimitris Polychronopoulos, Matthias Pfeifer, Vladimir Poroshin, Michaël Ughetto, Matthew J. Martin, Hannah Thorpe, Aurelie Bornot, Paul D. Smith, Ben Sidders, Jonathan R. Dry, Miika Ahdesmäki, Ultan McDermott, Eliseo Papa, Krishna C. Bulusu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Resistance to EGFR inhibitors presents a major obstacle in treating non-small cell lung cancer. Here, the authors develop a recommender system ranking genes based on trade-offs between diverse types of evidence linking them to potential mechanisms of
Externí odkaz:
https://doaj.org/article/5696d9d8b857488d965cb75a14d75b2a
Autor:
Chiyun Lee, Junxia Lin, Andrzej Prokop, Vancheswaran Gopalakrishnan, Richard N. Hanna, Eliseo Papa, Adrian Freeman, Saleha Patel, Wen Yu, Monika Huhn, Abdul-Saboor Sheikh, Keith Tan, Bret R. Sellman, Taylor Cohen, Jonathan Mangion, Faisal M. Khan, Yuriy Gusev, Khader Shameer
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Target prioritization is essential for drug discovery and repositioning. Applying computational methods to analyze and process multi-omics data to find new drug targets is a practical approach for achieving this. Despite an increasing number of metho
Externí odkaz:
https://doaj.org/article/e8f1ad335c164cdfb704fd8b0dec38dc
Autor:
Eliseo Papa, Michael Docktor, Christopher Smillie, Sarah Weber, Sarah P Preheim, Dirk Gevers, Georgia Giannoukos, Dawn Ciulla, Diana Tabbaa, Jay Ingram, David B Schauer, Doyle V Ward, Joshua R Korzenik, Ramnik J Xavier, Athos Bousvaros, Eric J Alm
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39242 (2012)
BACKGROUND:Pediatric inflammatory bowel disease (IBD) is challenging to diagnose because of the non-specificity of symptoms; an unequivocal diagnosis can only be made using colonoscopy, which clinicians are reluctant to recommend for children. Diagno
Externí odkaz:
https://doaj.org/article/dbee976b36a54737ac2c5bf0d90ea952
Autor:
Rhiannon R White, Sachiko Miyata, Eliseo Papa, Eric Spooner, Kleoniki Gounaris, Murray E Selkirk, Katerina Artavanis-Tsakonas
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 10, p e1340 (2011)
Trichinella spiralis is a zoonotic parasitic nematode that causes trichinellosis, a disease that has been identified on all continents except Antarctica. During chronic infection, T. spiralis larvae infect skeletal myofibres, severely disrupting thei
Externí odkaz:
https://doaj.org/article/cb97651065db4f33a35a148683a1edc4
Autor:
Andrew Hercules, Daniel Wright, Annalisa Buniello, Eliseo Papa, Maya Ghoussaini, Jeffrey C. Barrett, Alfredo Miranda, Eric B. Fauman, Edward Mountjoy, Mohd Anisul Karim, David Ochoa, Ian Dunham, Ellen M. Schmidt, Jeremy Schwartzentruber, John A. Todd, James D. Hayhurst, Miguel Carmona, Gareth Peat, Luca Fumis
Publikováno v:
Nature Genetics. 53:1527-1533
Genome-wide association studies (GWASs) have identified many variants associated with complex traits, but identifying the causal gene(s) is a major challenge. In the present study, we present an open resource that provides systematic fine mapping and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f2ca10259a7ab9f590a34cfe4b29c90
https://doi.org/10.1038/s41588-021-00945-5
https://doi.org/10.1038/s41588-021-00945-5
Autor:
Asier Gonzalez-Uriarte, Paola Roncaglia, Helen Parkinson, Ellen M. McDonagh, Denise Carvalho-Silva, Jeffrey C. Barrett, Cinzia Malangone, Maya Ghoussaini, Eliseo Papa, James D. Hayhurst, Zoë May Pendlington, Andrew Hercules, Simon Jupp, Ian Dunham, Edward Mountjoy, Ellen M. Schmidt, Annalisa Buniello, Javier Ferrer, Mohd Anisul Karim, Gautier Koscielny, Olga Vrousgou, Daniel Wright, Daniel Suveges, Gareth Peat, David G. Hulcoop, Alfredo Miranda, Tony Burdett, Miguel Carmona, David Ochoa, Jeremy Schwartzentruber, Luca Fumis, John A. Todd, Jacqueline A. L. MacArthur, Jarrod Baker, Sandra Machlitt-Northen
Publikováno v:
Nucleic Acids Research
Open Targets Genetics (https://genetics.opentargets.org) is an open-access integrative resource that aggregates human GWAS and functional genomics data including gene expression, protein abundance, chromatin interaction and conformation data from a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68993856a69cde406777188f394460a
http://europepmc.org/articles/PMC7778936
http://europepmc.org/articles/PMC7778936
Autor:
Vladimir Poroshin, Michael Ughetto, Gavin Edwards, Andriy Nikolov, Eliseo Papa, Marina Pettersson, Erik T. Jansson, Benedek Rozemberczki, David Geleta, Richard J. Jackson, S Nilsson, Andrej Lamov, Anna Gogleva, Timothy Scrivener
The use of knowledge graphs as a data source for machine learning methods to solve complex problems in life sciences has rapidly become popular in recent years. Our Biological Insights Knowledge Graph (BIKG) combines relevant data for drug developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90ce3ca21b7af87d87b8b251fb01d37b
https://doi.org/10.1101/2021.10.28.466262
https://doi.org/10.1101/2021.10.28.466262
Publikováno v:
RecSys
Drug discovery is notorious for its low success rates [5]. Despite best research efforts, the majority of drugs fail at early stages of development, even before they enter clinical trials. This phenomenon stems from the inherent complexity of biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d11b9b4ce6488fb68583c26a00f8af36
https://doi.org/10.1145/3460231.3474598
https://doi.org/10.1145/3460231.3474598
Autor:
Miika Ahdesmaki, Ultan McDermott, Vladimir Poroshin, Jonathan R. Dry, Dimitris Polychronopoulos, Krishna C. Bulusu, Anna Gogleva, Eliseo Papa, Matthias Pfeifer, Benjamin S. Sidders, Michael Ughetto
Resistance to EGFR inhibitors (EGFRi) presents a major obstacle in treating non-small cell lung cancer (NSCLC). One of the most exciting new ways to find potential resistance markers involves running functional genetic screens, such as CRISPR, follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde4f99759984547b6ba97a281eb3050
https://doi.org/10.1101/2021.07.23.453506
https://doi.org/10.1101/2021.07.23.453506
Autor:
Ellen M. McDonagh, Denise Carvalho-Silva, Jeremy Schwartzentruber, Adam Faulconbridge, Asier Gonzalez-Uriarte, Michaela Spitzer, Ian Dunham, Eliseo Papa, Elaine McAuley, David Ochoa, Luca Fumis, Chuang Kee Ong, Andrea Pierleoni, Daniel Suveges, Jarrod Baker, Andrew Hercules, Gareth Peat, Edward Mountjoy, Eirini Petsalaki, Prudence Mutowo, Miguel Carmona, Gautier Koscielny, Miguel Pignatelli, David G. Hulcoop, Olesya Razuvayevskaya, Sandra Machlitt-Northen, Cinzia Malangone, Javier Ferrer, Mohd Anisul Karim, Maya Ghoussaini, Alfredo Miranda, Arwa Bin Raies
Publikováno v:
Nucleic Acids Research
The Open Targets Platform (https://www.targetvalidation.org/) provides users with a queryable knowledgebase and user interface to aid systematic target identification and prioritisation for drug discovery based upon underlying evidence. It is publicl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2664c3a844cec920089d5e95389b51c2
https://pubmed.ncbi.nlm.nih.gov/33196847
https://pubmed.ncbi.nlm.nih.gov/33196847