Alkylated Flavanones from the Bark of Cryptocarya chartacea As Dengue Virus NS5 Polymerase Inhibitors

Autor: Cyril Poullain, Jean-Claude Guillemot, Bruno Canard, Françoise Guéritte, Marc Litaudon, Vincent Dumontet, Elise Tran Huu Dau, Pierre-Marie Allard, Cécilia Eydoux

Publikováno v: Journal of Natural Products
Journal of Natural Products, American Chemical Society, 2011, 74 (11), pp.2446-53. ⟨10.1021/np200715v⟩

International audience; An in vitro screening of New Caledonian plants allowed the selection of several species with a significant dengue virus NS5 RNA-dependent RNA polymerase (RdRp) inhibiting activity. The chemical investigation of Cryptocarya cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a758368e982f4d194ac4bbdf84b0046b
https://doi.org/10.1021/np200715v

Chiral imines on the wave: reactivity of tert-butyl acrylate and stereoselectivity determination using NMR in liquid crystals

Autor: Olivier Lafon, Marie-Elise Tran Huu Dau, Li Chen, Philippe Lesot, Françoise Dumas, Pierre Chaminade, André Loupy, Franck Le Bideau, Lai Wei, Lucie Vandromme

Publikováno v: Proceedings of MOL2NET, International Conference on Multidisciplinary Sciences.

In connection with synthetic applications, we have foreseen to study the reactivity of the poorly reactive tert-butyl acrylate electrophile with chiral imines of unsymmetrical ketones, using conventional or microwave flash heating under carefully con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f3c5e9296cc5a4b29524011587b827a
https://doi.org/10.3390/mol2net-1-a003

Hyrtiazepine, an Azepino-indole-Type Alkaloid from the Red Sea Marine Sponge Hyrtios erectus

Autor: Marie-Thérèse Martin, Diaa T. A. Youssef, Pierre Sauleau, Marie-Elise Tran Huu Dau, Marie-Lise Bourguet-Kondracki

Publikováno v: Journal of Natural Products
Journal of Natural Products, American Chemical Society, 2006, 69 (12), pp.1676-9. ⟨10.1021/np060132r⟩
Journal of Natural Products, American Chemical Society, 2006, 69(12), pp.1676-1679. ⟨10.1021/np060132r⟩

International audience; Biological and chemical investigations of the methanolic crude extract of the Red Sea marine sponge Hyrtios erectus led to the isolation of a novel azepino-indole-type alkaloid named hyrtiazepine (2) and 5-hydroxy-1H-indole-3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf95319649c2ed354e8fcb52de8e56be
https://doi.org/10.1021/np060132r

An unprecedented outcome of the lithium–ammonia reduction of enones: the formation of cyclopropanols

Autor: Cyrille Thominiaux, Didier Desmaële, Christine Miet, Christian Cavé, Jean d'Angelo, Marie-Elise Tran Huu-Dau, Mohammed Nour, Georges Morgant, Françoise Dumas

Publikováno v: Tetrahedron Letters. 43:9649-9652

An unusual process takes place during the lithium–ammonia reduction of a variety of cyclic enones bearing an ester group in the γ-position, furnishing cyclopropanols. The reason for this unprecedented outcome has been attributed to the through-spa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39168b2dfce4fd551152e88e7973148a
https://doi.org/10.1016/s0040-4039(02)02382-1

From enantiopure hydroxyaldehydes to complex heterocyclic scaffolds: development of domino petasis/diels-alder and cross-metathesis/michael addition reactions

Autor: Jean-Marie Beau, Pascal Retailleau, Alexandre Cannillo, Marie-Elise Tran Huu Dau, Bogdan I. Iorga, Stéphanie Norsikian

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2014, 20 (38), pp.12133-12143. ⟨10.1002/chem.201402965⟩

International audience; One-step assembly of hexahydroisoindole scaffolds by a sequence that combines the Petasis (borono-Mannich) and Diels-Alder reactions is described. The unique selectivity observed experimentally was confirmed by quantum calcula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28754013ad06ef6a7d27bb4b1d36aa43
https://hal.archives-ouvertes.fr/hal-01065678