A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.

Autor: Carmen Schwechheimer, Kassidy Hebert, Sarvind Tripathi, Praveen K Singh, Kyle A Floyd, Elise R Brown, Monique E Porcella, Jacqueline Osorio, Joseph T M Kiblen, Fernando A Pagliai, Knut Drescher, Seth M Rubin, Fitnat H Yildiz

Publikováno v: PLoS Pathogens, Vol 16, Iss 8, p e1008745 (2020)

Production of an extracellular matrix is essential for biofilm formation, as this matrix both secures and protects the cells it encases. Mechanisms underlying production and assembly of matrices are poorly understood. Vibrio cholerae, relies heavily

Externí odkaz: https://doaj.org/article/cf898045b4b347c9906856ac86023e93

A Strategy for Direct Chemical Activation of the Retinoblastoma Protein

Autor: Jason R. Burke, Walter M. Bray, R. Scott Lokey, Cameron R. Pye, Seth M. Rubin, Elise R. Brown

Publikováno v: Pye, CR; Bray, WM; Brown, ER; Burke, JR; Lokey, RS; & Rubin, SM. (2016). A Strategy for Direct Chemical Activation of the Retinoblastoma Protein. ACS CHEMICAL BIOLOGY, 11(5), 1192-1197. doi: 10.1021/acschembio.6b00011. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/2p8939v5
ACS chemical biology, vol 11, iss 5

The retinoblastoma (Rb) tumor suppressor protein negatively regulates cell proliferation by binding and inhibiting E2F transcription factors. Rb inactivation occurs in cancer cells upon cyclin-dependent kinase (Cdk) phosphorylation, which induces E2F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30ff79de1d227a78396c5e2908d7743
http://www.escholarship.org/uc/item/2p8939v5