Výsledky vyhledávání - "Elise Maubert"

Akademický článek

Development and characterization of a human three-dimensional chondrosarcoma culture for in vitro drug testing.

Autor: Aurélien Voissiere, Elodie Jouberton, Elise Maubert, Françoise Degoul, Caroline Peyrode, Jean-Michel Chezal, Élisabeth Miot-Noirault

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0181340 (2017)

It has been suggested that chemoresistance of chondrosarcoma (CHS), the cartilage tumor, is caused by the phenotypic microenvironmental features of the tumor tissue, mainly the chondrogenic extracellular matrix (ECM), and hypoxia. We developed and ch

Externí odkaz: https://doaj.org/article/e67f8b35e30240b89e80ccd2a55a04a9

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Simultaneous proteoglycans and hypoxia mapping of chondrosarcoma environment by frequency selective CEST MRI

Autor: Leslie Mazuel, Sébastien Schmitt, Elisabeth Miot-Noirault, Philippe Auzeloux, Guilhem Pages, Roxane Autissier, Elise Maubert, Caroline Peyrode, Amidou Traore, Jean-Marie Bonny

Publikováno v: Magnetic Resonance in Medicine
Magnetic Resonance in Medicine, Wiley, In press, ⟨10.1002/mrm.28781⟩
Magnetic Resonance in Medicine, In press, 86 (2), pp.1008-1018. ⟨10.1002/mrm.28781⟩

International audience; Purpose: To evaluate the relevance of CEST frequency selectivity in simultaneous in vivo imaging of both of chondrosarcoma’s phenotypic features, that are, its high proteoglycan concentration and its hypoxic core.Methods: Sw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac30f7408f3e1ab2c55e1f6e9cc7ade
https://hal.archives-ouvertes.fr/hal-03187913/document

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Relevance of the combination of external beam radiotherapy with the hypoxia-activated prodrug ICF05016 in an experimental model of extraskeletal myxoid chondrosarcoma

Autor: Elisabeth Miot-Noirault, Elise Maubert, Françoise Degoul, Valérie Weber, Aurélien Voissiere, Jean-Michel Chezal, Emmanuel Chautard, Véronique Dedieu, Yvain Gerard

Publikováno v: Investigational New Drugs
Investigational New Drugs, Springer Verlag, 2020, ⟨10.1007/s10637-020-01002-4⟩

Currently, there is no gold standard treatment for Extraskeletal Myxoid Chondrosarcomas (EMC) making wide margin surgical resection the most effective alternative treatment. Nevertheless, in previous preclinical studies our lab demonstrated the poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be99db8b5d34070b7b2a23fc09f1a08f
https://pubmed.ncbi.nlm.nih.gov/32948981

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Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapy

Autor: Yvain Gerard, Sébastien Tarrit, Donia Ghedira, Elise Maubert, Elisabeth Miot-Noirault, Jean-Michel Chezal, Vincent Gaumet, Marie-Josèphe Galmier, Damien Canitrot, Aurélien Voissiere, Valérie Weber, Caroline Peyrode

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2020, 98, pp.103747. ⟨10.1016/j.bioorg.2020.103747⟩
Bioorganic Chemistry, 2020, 98, pp.103747. ⟨10.1016/j.bioorg.2020.103747⟩

International audience; The tumor microenvironment in chondrosarcoma (CHS), a chemo- and radio-resistant cancer provides unique hallmarks for developing a chondrosarcoma targeted drug-delivery system. Tumor targeting could be achieved using a quatern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361f02285fce4f43801dc08e9e87bfb7
https://hal.uca.fr/hal-02866765/document

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Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma

Autor: Magali Vivier, Jean-Michel Chezal, Elise Maubert, Donia Ghedira, Elisabeth Miot-Noirault, Jamil Kraïem, Farhat Farhat, Valérie Weber, Aurélien Voissiere, Caroline Peyrode, Yvain Gerard

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 158, pp.51-67. ⟨10.1016/j.ejmech.2018.08.060⟩

International audience; Due to an abundant chondrogenic, poorly vascularized and particularly hypoxic extracellular matrix, chondrosarcoma, a malignant cartilaginous tumour, is chemo- and radio-resistant. Surgical resection with wide margins remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5e39906cc7547f2c482ec7169257d3
https://hal.archives-ouvertes.fr/hal-01926337/document

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CEST MRI to contrast chondrosarcoma tumors: two contrasts in one acquisition

Autor: Leslie Mazuel, Roxanne Autissier, Elise Maubert, Aurélien Voissiere, Valérie WEBER, Yvain Gerard, Sophie Besse, M Bonny, J., Elisabeth Miot-Noirault, Caroline Peyrode, Guilhem Pages

Publikováno v: 13. European Molecular Imaging Meeting
13. European Molecular Imaging Meeting, Mar 2018, San Sebastián, Spain
2018; 13. European Molecular Imaging Meeting, San Sebastián, ESP, 2018-03-20-2018-03-23
HAL
Congrès EMIM European Society of Molecular Imaging
Congrès EMIM European Society of Molecular Imaging, Mar 2018, SAN SEBASTIAN, Spain

International audience; Introduction Chondrosarcoma (a malignant tumor of cartilage) is poorly vascularized and rich in proteoglycans (PGs).1 If the hypoxic and proteoglycan status of the tumor can be assessed by TEP imaging2 and scintigaphy3,4,5 it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::82f101daf3f8214bee11ece929f0e983
https://hal.inrae.fr/hal-02733597

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