A multi-parameter response prediction model for rituximab in rheumatoid arthritis

Autor: Rabia Agca, Tamarah D. de Jong, Alexandre E. Voskuyl, Xavier Mariette, Saskia Vosslamber, Birgit I. Witte, Cornelis L. Verweij, Jérémie Sellam, M.W.P. Tsang-A-Sjoe, Elise Mantel, Johannes W. Bijlsma, Michael T. Nurmohamed

Publikováno v: de Jong, T D, Sellam, J, Agca, R, Vosslamber, S, Witte, B I, Tsang-A-Sjoe, M, Mantel, E, Bijlsma, J W, Voskuyl, A E, Nurmohamed, M T, Verweij, C L & Mariette, X 2018, ' A multi-parameter response prediction model for rituximab in rheumatoid arthritis ', Joint Bone Spine, vol. 85, no. 2, pp. 219-226 . https://doi.org/10.1016/j.jbspin.2017.02.015
Joint Bone Spine, 85(2), 219-226. Elsevier Masson

Objectives To validate the IFN response gene (IRG) set for the prediction of non-response to rituximab in rheumatoid arthritis (RA) and assess the predictive performance upon combination of this gene set with clinical parameters. Methods In two indep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29e83a42f78785dad47fa40c5a23d28
http://www.scopus.com/inward/record.url?scp=85019030805&partnerID=8YFLogxK

OP0021 IDENTIFICATION OF DIFFERENTIALLY EXPRESSED GENES IN EARLY RHEUMATOID ARTHRITIS PATIENTS RESPONDING TO TOCILIZUMAB

Autor: Gerrit Jansen, P.M.J. Welsing, IB Muller, Helen R. Gosselt, L. Padyukov, C. J. van der Laken, Elise Mantel, R. de Jonge, Maxime Verhoeven, M. Lin, T. De Jong, F.P.J.G. Lafeber, K. Chatzidionysiou

Publikováno v: Annals of the Rheumatic Diseases. 80:12.2-12

Background:Tocilizumab (TCZ) is a monoclonal antibody that binds to the interleukin 6 receptor (IL-6R), inhibiting IL-6R signal transduction to downstream inflammatory mediators. TCZ has shown to be effective as monotherapy in early rheumatoid arthri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4236d668b2e4536b35baa343140c54eb
https://doi.org/10.1136/annrheumdis-2021-eular.3668

Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [

Autor: Durga M S H, Chandrupatla, Gerrit, Jansen, Elise, Mantel, Philip S, Low, Takami, Matsuyama, René P, Musters, Albert D, Windhorst, Adriaan A, Lammertsma, Carla F M, Molthoff, Conny J, van der Laken

Publikováno v: Contrast Media & Molecular Imaging

Background In rheumatoid arthritis, articular inflammation is a hallmark of disease, while the involvement of extra-articular tissues is less well defined. Here, we examined the feasibility of PET imaging with the macrophage tracer [18F]fluoro-PEG-fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d19863f9eb17b9b836ea246e2109ac1e
https://pubmed.ncbi.nlm.nih.gov/29681783

Physiological evidence for diversification of IFN alpha- and IFN beta-mediated response programs in different autoimmune diseases

Autor: Jiri Vencovsky, Johannes W. J. Bijlsma, John G. Wesseling, Florian Deisenhammer, Michael T. Nurmohamed, Ingrid E. Lundberg, D. Michiel Pegtel, Sander de Ridder, Cornelis L. Verweij, Conny J. van der Laken, Dirkjan van Schaardenburg, Tamarah D. de Jong, Saskia Vosslamber, Cyra E. Leurs, Elise Mantel, Joep Killestein, Irene E. M. Bultink, Harald Hegen, Alexandre E Voskuyl, Tineke C. T. M. van der Pouw Kraan

Publikováno v: Arthritis Research & Therapy, 18:49. BioMed Central
de Jong, T D, Vosslamber, S, Mantel, E, de Ridder, S, Wesseling, J G, Kraan, T C T M V D P, Leurs, C, Hegen, H, Deisenhammer, F, Killestein, J, Lundberg, I E, Vencovsky, J, Nurmohamed, M T, van Schaardenburg, D, Bultink, I E M, Voskuyl, A E, Pegtel, D M, van der Laken, C J, Bijlsma, J W & Verweij, C L 2016, ' PHYSIOLOGICAL EVIDENCE FOR DIVERSIFICATION OF IFN alpha-AND IFN beta-MEDIATED RESPONSE PROGRAMS IN DIFFERENT AUTOIMMUNE DISEASES ', Annals of the Rheumatic Diseases, vol. 75, pp. A52-A52 . https://doi.org/10.1136/annrheumdis-2016-209124.124
de Jong, T D, Vosslamber, S, Mantel, E, de Ridder, S, Wesseling, J G, van der Pouw Kraan, T, Leurs, C, Hegen, H, Deisenhammer, F, Killestein, J, Lundberg, I E, Vencovsky, J, Nurmohamed, M T, van Schaardenburg, D, Bultink, I E M, Voskuyl, AE, Pegtel, DM, van der Laken, C J, Bijlsma, J W J & Verweij, C L 2016, ' Physiological evidence for diversification of IFN alpha-and IFN beta-mediated response programs in different autoimmune diseases ', Arthritis Research & Therapy, vol. 18, 49 . https://doi.org/10.1186/s13075-016-0946-9
Annals of the Rheumatic Diseases, 75, A52-A52. BMJ Publishing Group
Arthritis Research & Therapy

Background Activation of the type I interferon (IFN) response program is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), myositis (IIM) and rheumatoid arthritis (RA). While IFNα contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdafab872e636f6cd3731d4633d6ab0b
https://research.vumc.nl/en/publications/4b88ae4b-94db-4b3f-9f6f-a5e2398aa624

A1.31 The type I IFN signature in sorted leukocyte subsets from peripheral blood of rheumatoid arthritis patients; a major contribution by granulocytes

Autor: Elise Mantel, D. van Schaardenburg, Hetty J. Bontkes, Joyce Lübbers, Cornelis L. Verweij, J. W. J. Bijlsma, C. J. van der Laken, T. D. de Jong, Saskia Vosslamber, Samina A. Turk

Publikováno v: Annals of the Rheumatic Diseases. 75:A13.2-A13

Background and objectives A subgroup of rheumatoid arthritis (RA) patients displays elevated type I IFN response gene (IRG) expression in peripheral blood, which has shown clinical relevance in relation to disease onset and therapy response. Identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a5a0891cef2295efdfdf6023be238b7
https://doi.org/10.1136/annrheumdis-2016-209124.31