Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Elise M Lewis"'
Autor:
Natasha R Catlin, Christopher J Bowman, Sarah N Campion, Elise M Lewis, William S Nowland, Christine Stethem, Gregg D Cappon
Publikováno v:
Toxicological Sciences. 189:225-236
Ervogastat (PF-06865571) is a small molecule diacylglycerol acyltransferase 2 (DGAT2) inhibitor being developed for the oral treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis. DGAT2 is a key enzyme in triglyceride synthesis in tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8406685f49264eb55b560fab52e2d7d6
https://doi.org/10.1093/toxsci/kfac077
https://doi.org/10.1093/toxsci/kfac077
Autor:
William S. Nowland, Steven W. Kumpf, Trenton T. Ross, Christopher J. Bowman, Gregg D. Cappon, Donald S Stedman, Scott D Davenport, William P. Esler, Christine Stethem, Natasha R. Catlin, Elise M. Lewis, Sarah N. Campion
Publikováno v:
Toxicological Sciences. 179:183-194
Acetyl-CoA carboxylase (ACC) is an enzyme within the de novo lipogenesis (DNL) pathway and plays a role in regulating lipid metabolism. Pharmacologic ACC inhibition has been an area of interest for multiple potential indications including oncology, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6d9eb6a77626c055c46264ceba500b
https://doi.org/10.1093/toxsci/kfaa169
https://doi.org/10.1093/toxsci/kfaa169
Autor:
Manoj Aggarwal, James Akingbasote, Arturo Anadón, Gregory J. Anger, Anthony E. Archibong, Irma Ares, Michael Aschner, Daiana S. Avila, Denise C. Bailey, Norman J. Barlow, Sudheer Beedanagari, P.P. Beltyukov, Karyn Bischoff, Carina Rodrigues Boeck, William M. Bracken, Emily Brehm, Richard M. Breyer, Susan Bright-Ponte, Mirjana Milosevic Brockett, Luisa Campagnolo, Edward W. Carney, Andrew Charrette, Sandrine Fleur Chebekoue, Catheryne Chiang, Wei-Chun Chou, Jane K. Cleal, Toby B. Cole, Daniel Cook, Robert W. Coppock, Lucio G. Costa, Margarita Curras-Collazo, Wanying Dai, Khoi Dao, Rosane Souza Da Silva, T. Zane Davis, Francisco Dominguez, Robin B. Doss, Margitta M. Dziwenka, Brian Enright, Carmen Estevan, Timothy J. Evans, Anna M. Fan, Marcelo Farina, Suzanne E. Fenton, Ayhan Filazi, Vanessa A. Fitsanakis, Rex FitzGerald, John Flaskos, Jodi A. Flaws, S.J.S. Flora, Vekataseshu K. Ganjam, Dale R. Gardner, Ramesh C. Garg, Jacqueline M. Garrick, Vincent F. Garry, Janee Gelineau-van Waes, Keith M. Godfrey, Yu V. Golubentseva, Roberto González-Martín, Benedict T. Green, Consuelo Guerri, Kavita Gulati, P.K. Gupta, Ramesh C. Gupta, Rekha K. Gupta, Najla Guthrie, Jeffery O. Hall, Alan J. Hargreaves, Kenneth J. Harris, Bridgett N. Hill, Corey J. Hilmas, Alan M. Hoberman, Karin S. Hougaard, Sinan Ince, Poorni R. Iyer, Nicklas R. Jacobsen, Starling Kalpana, Ramesh Kandimalla, Arthi Kanthasamy, Anumantha Kanthasamy, N.S. Khlebnikova, Nils Klüver, Prasada Rao S. Kodavanti, Kannan Krishnan, Shaila Kulkarni, Ozgur Kuzukiran, Rajiv Lall, Jessica Legradi, Rohan M. Lewis, Elise M. Lewis, Xin Li, Pinpin Lin, Bommanna G. Loganathan, Ivo F. Machado, Brinda Mahadevan, Susan L. Makris, Jitendra K. Malik, Ana Paula Marreilha dos Santos, Judit Marsillach, María Rosa Martínez-Larrañaga, María Aránzazu Martínez, Klara Matouskova, Roger O. McClellan, Dejan Milatovic, Ali Mustafa Mohammed, Thomas J. Montine, Peter Møller, Pushpinder Kaur Multani, Mingwei Ni, Efstathios Nikolaidis, Meliton N. Novilla, Stephanie Padilla, Carlos M. Palmeira, David Pamies, Manesh Kumar Panner Selvam, María Pascual, Jayant Patwa, Ashley Phillips, Micheline Piquette-Miller, V.B. Popov, M. Margaret Pratt, G.A. Protasova, Nishant Rai, João Ramalho-Santos, Aramandla Ramesh, Kausik Ray, Arunabha Ray, Aiguo Ren, Stephen J. Renaud, Drucilla J. Roberts, Lu Rongzhu, Magdalini Sachana, Heidi Sahlman, Nitin Saini, Vandna Saini, L.V. Shabasheva, Abha Sharma, Suresh C. Sikka, Marilyn Helen Silva, Ilker Simsek, Rajkumar Singh Kalra, Anita Sinha, Miguel A. Sogorb, Offie P. Soldin, Chunjuan Song, Ajay Srivastava, Szabina A. Stice, Tammy E. Stoker, Clinton A. Stonecipher, Sandra Szlapinski, Shihori Tanabe, Arun Tatiparthi, João Batista Teixeira da Rocha, Suresh Kumar Thokchom, Belen Tornesi, Vanda Torous, Peter Truran, Matthew C. Valdez, Laura N. Vandenberg, Neil Vargesson, Eugenio Vilanova, Kirsi H. Vähäkangas, Suryanarayana V. Vulimiri, Genoa R. Warner, Kevin D. Welch, Daniel C. Williams, Moges Woldemeskel, Jae-Ho Yang, Zhaobao Yin, Xiaoyou Ying, Begum Yurdakok-Dikmen, Snjezana Zaja-Milatovic, Changqing Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0dc2704509109027fc26dbd683a5376
https://doi.org/10.1016/b978-0-323-89773-0.01002-x
https://doi.org/10.1016/b978-0-323-89773-0.01002-x
Autor:
Linda G. Roberts, Elise M. Lewis
Publikováno v:
Birth Defects Research.
BACKGROUND: This paper updates the history of the Teratology Society, now known as the Society for Birth Defects Research and Prevention (BDRP), for its first 60 years and describes the current strategy to position the Society to continue to advance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5a0d82c92d2bddea6da6dc11a2f92a
https://doi.org/10.1002/bdr2.1688
https://doi.org/10.1002/bdr2.1688
Autor:
Elise M. Lewis, Atish Patel, Alan M. Hoberman, Valerie T. Politano, Robert M. Diener, A.M. Api
Publikováno v:
International Journal of Toxicology. 36:252-259
Reproductive toxicity of isobornyl acetate (IA), a widely used fragrance ingredient, was investigated in a 1-generation reproduction study in which 25 Crl: CD (Sprague-Dawley) rats/sex/group were gavaged with dosages of 0 (corn oil vehicle), 30, 100,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58236a514b27c4f81d41f177ba196e7
https://doi.org/10.1177/1091581817708197
https://doi.org/10.1177/1091581817708197
Autor:
Natasha R. Catlin, Christopher J. Bowman, Gregg D. Cappon, Scott Engel, Elise M. Lewis, S. Thibault, A. Sacaan
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 88
Palbociclib is a selective inhibitor of the cyclin-dependent kinase (CDK) 4/6, approved for the treatment of breast cancer. We assessed the potential effects of oral administration of palbociclib on reproduction and development. There were no effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a01a1f049adb61525e55b4b165d484a
https://pubmed.ncbi.nlm.nih.gov/31362042
https://pubmed.ncbi.nlm.nih.gov/31362042
Autor:
Dinesh Stanislaus, Lorraine M. Posobiec, Elise M. Lewis, Howard M. Solomon, Estella M. Cox, Kai‐fen Wang
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 107:76-84
Embryo-fetal development (EFD) studies, typically in pregnant rats and rabbits, are conducted prior to enrolling females of reproductive age in clinical trials. Common rabbit strains used are the New Zealand White (NZW) and Dutch Belted (DB). As feta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec2e75befa5d0ee535ba4944093081c
https://doi.org/10.1002/bdrb.21173
https://doi.org/10.1002/bdrb.21173
Autor:
Alan M. Hoberman, Elise M. Lewis
The testing guidelines for reproductive and developmental toxicity were established to evaluate the effects of exposure to a drug at any point in the life cycle; however, the exposure from birth to puberty was not directly covered in the guidelines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3dea64b025c7d74de536456ad1e477
https://doi.org/10.1016/b978-0-12-804239-7.00007-x
https://doi.org/10.1016/b978-0-12-804239-7.00007-x
Autor:
Manoj Aggarwal, Shruti Agrawal, Arturo Anadón, Gregory J. Anger, Anthony E. Archibong, Irma Ares, Michael Aschner, Daiana S. Avila, Denise C. Bailey, Nancy C. Baker, Norman J. Barlow, Sudheer Beedanagari, Karyn Bischoff, William M. Bracken, Emily Brehm, Richard M. Breyer, Susan Bright-Ponte, Luisa Campagnolo, Edward W. Carney, Victor Castellano, Sandrine Fleur Chebekoue, Catheryne Chiang, Wei-Chun Chou, Supratim Choudhuri, Jane K. Cleal, Robert W. Coppock, Lucio G. Costa, Margarita Curras-Collazo, João Batista Teixeira da Rocha, Rosane S. Da Silva, T. Zane Davis, Robin B. Doss, Margitta M. Dziwenka, Brian Enright, Per Eriksson, Carmen Estevan, Timothy J. Evans, Bengt Fadeel, Anna M. Fan, Ali S. Faqi, Marcelo Farina, Suzanne E. Fenton, Maureen H. Feuston, Ayhan Filazi, Vanessa A. Fitsanakis, John Flaskos, Jodi A. Flaws, Swaran J.S. Flora, Vekataseshu K. Ganjam, Dale R. Gardner, Nicole M. Gardner, Ramesh C. Garg, Vincent F. Garry, Janee Gelineau-van Waes, Keith M. Godfrey, Consuelo Guerri, Marina Guizzetti, Kavita Gulati, Mary Gulumian, Pawan K. Gupta, Ramesh C. Gupta, Rekha K. Gupta, Sharon M. Gwaltney-Brant, Jeffrey O. Hall, Deborah K. Hansen, Alan J. Hargreaves, Kenneth J. Harris, Alan M. Hoberman, Karin S. Hougaard, Sinan Ince, Amy L. Inselman, Poorni Iyer, Nicklas R. Jacobsen, Valerian E. Kagan, Starling Kalpana, Kotaro Kaneko, Anumantha Kanthasamy, Arthi Kanthasamy, Vesa Karttunen, Hyung Sik Kim, Thomas B. Knudsen, Prasada Rao S. Kodavanti, Kannan Krishnan, Shaila Kulkarni, Rajiv Lall, Michelle A. Lasher, Scott B. Laudert, Byung-Mu Lee, Jessica Legradi, Maxwell C.K. Leung, Elise M. Lewis, Rohan M. Lewis, Xin Li, Pinpin Lin, Bommanna G. Loganathan, Jan Ludvig Lyche, Robert C. MacPhail, Brinda Mahadevan, Jitendra K. Malik, Ana Paula Marreilha dos Santos, Maria Aranzazu Martínez, Maria Rosa Martínez-Larrañaga, David McClary, Fabiano P. Menezes, Jerrold S. Meyer, Dejan Milatovic, Ida R. Miller Mukherjee, Ali Mustafa Mohammed, Peter Møller, Thomas J. Montine, Mingwei Ni, Efstathios Nikolaidis, Meliton N. Novilla, Stephanie Padilla, Carlos M. Palmeira, David Pamies, Kip E. Panter, María Pascual, Claudia Pellacani, Brian J. Piper, Micheline Piquette-Miller, Vadim B. Popov, M. Margaret Pratt, Galina A. Protasova, Nishant Rai, João Ramalho-Santos, Aramandla Ramesh, Arunabha Ray, Kausik Ray, Aiguo Ren, Stephen J. Renaud, Ronald T. Riley, Drucilla J. Roberts, Lu Rongzhu, Magdalini Sachana, Kai M. Savolainen, Lilia V. Shabasheva, Kathleen T. Shiverick, Suresh C. Sikka, Miguel A. Sogorb, Offie P. Soldin, Chunjuan Song, Ajay Srivastava, Szabina A. Stice, Tammy E. Stoker, Jaideep S. Toor, Belen Tornesi, Peter Truran, Kirsi Vähäkangas, Joseph Valdez, Neil Vargesson, Henrik Viberg, Eugenio Vilanova, Kenneth A. Voss, Suryanarayana V. Vulimiri, Kevin D. Welch, Daniel C. Williams, Moges Woldemeskel, Jae-Ho Yang, Zhaobao Yin, Xiaoyou Ying, Begum Yurdakok-Dikmen, Snjezana Zaja-Milatovic, Changqing Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d3ec8a26b57cd9932d33f7fbce32e1a
https://doi.org/10.1016/b978-0-12-804239-7.01002-7
https://doi.org/10.1016/b978-0-12-804239-7.01002-7
Autor:
Colin Hall, Elise M. Lewis, Graeme J. Moffat, M. Benjamin Hock, Marc W. Retter, Mark Loomis, Jeanine L. Bussiere, Gary J. Chellman, Gayle Kwon
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:178-188
Understanding species differences in the placental transfer of monoclonal antibodies is important to inform species selection for nonclinical safety assessment, interpret embryo-fetal changes observed in these studies, and extrapolate their human rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4f02f1f492c329518197add37bfc60
https://doi.org/10.1002/bdrb.21105
https://doi.org/10.1002/bdrb.21105