Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties

Autor: Maisa N. G. van Genderen, Jeroen Kneppers, Anniek Zaalberg, Elise M. Bekers, Andries M. Bergman, Wilbert Zwart, Federica Eduati

Publikováno v: npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)

Abstract Inhibiting androgen receptor (AR) signaling through androgen deprivation therapy (ADT) reduces prostate cancer (PCa) growth in virtually all patients, but response may be temporary, in which case resistance develops, ultimately leading to le

Externí odkaz: https://doaj.org/article/ccd027487f2c48e3a61d12b40884f5e4

First-in-patient study of OTL78 for intraoperative fluorescence imaging of prostate-specific membrane antigen-positive prostate cancer: a single-arm, phase 2a, feasibility trial

Autor: Judith A Stibbe, Hilda A de Barros, Daan G J Linders, Shadhvi S Bhairosingh, Elise M Bekers, Pim J van Leeuwen, Philip S Low, Sumith A Kularatne, Alexander L Vahrmeijer, Jacobus Burggraaf, Henk G van der Poel

Publikováno v: The Lancet Oncology. 24:457-467

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a96486fa36f20024a8790aa4ded6cd83
https://doi.org/10.1016/s1470-2045(23)00102-x

Predictive Value of Cribriform and Intraductal Carcinoma for the Nomogram-based Selection of Prostate Cancer Patients for Pelvic Lymph Node Dissection

Autor: Hilda A. de Barros, Sebastiaan Remmers, Henk B. Luiting, Geert J.L.H. van Leenders, Monique J. Roobol, Elise M. Bekers, Amer Amin, Anne-Maree Haynes, Warick Delprado, Phillip D. Stricker, Henk G. van der Poel, Theodorus H. van der Kwast, Pim J. van Leeuwen

Publikováno v: de Barros, H A, Remmers, S, Luiting, H B, van Leenders, G J L H, Roobol, M J, Bekers, E M, Amin, A, Haynes, A-M, Delprado, W, Stricker, P D, van der Poel, H G, van der Kwast, T H & van Leeuwen, P J 2022, ' Predictive Value of Cribriform and Intraductal Carcinoma for the Nomogram-based Selection of Prostate Cancer Patients for Pelvic Lymph Node Dissection ', Urology, vol. 168, pp. 156-164 . https://doi.org/10.1016/j.urology.2022.04.043
Urology, 168, 156-164. Elsevier Inc.

Objective: To assess the predictive value of biopsy-identified cribriform carcinoma and/or intraductal carcinoma (CR/IDC) within the Briganti and MSKCC nomograms predicting lymph node metastasis (LNM) in patients with primary prostate cancer (PCa). M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad422606645cdffc035464b48025121
http://www.scopus.com/inward/record.url?scp=85135504830&partnerID=8YFLogxK

Clinical value of preoperative serum tumor markers CEA, CA19-9, CA125, and CA15-3 in surgically treated urachal cancer

Autor: Laura E. Stokkel, Huub H. van Rossum, Maaike W. van de Kamp, Thierry N. Boellaard, Elise M. Bekers, Niels F.M. Kok, Bas W.G. van Rhijn, Laura S. Mertens

Publikováno v: Urologic Oncology: Seminars and Original Investigations, 41(7), 326.e17-326.e24. Elsevier Inc.
Stokkel, L E, van Rossum, H H, van de Kamp, M W, Boellaard, T N, Bekers, E M, Kok, N F M, van Rhijn, B W G & Mertens, L S 2023, ' Clinical value of preoperative serum tumor markers CEA, CA19-9, CA125, and CA15-3 in surgically treated urachal cancer ', Urologic Oncology: Seminars and Original Investigations, vol. 41, no. 7, pp. 326.e17-326.e24 . https://doi.org/10.1016/j.urolonc.2023.01.018

Introduction: Urachal adenocarcinoma (UrAC) is a very rare malignancy with a poor prognosis. The role of preoperative serum tumor markers (STMs) in UrAC is unknown. The aim of this study was to assess the clinical value of elevated STMs including car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff73920b16d2b2f169e6e9c826c59e8
https://research.vumc.nl/en/publications/d2d28123-223e-462c-aee2-5b06a04bd046

Supplementary Figure from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence

Autor: Wilbert Zwart, Andries M. Bergman, Henk van der Poel, Nathan A. Lack, Lisa M. Butler, Lodewyk F.A. Wessels, Matthew L. Freedman, Amina Zoubeidi, Felix Y. Feng, René H. Medema, Maarten Altelaar, Bogdan Pasaniuc, Ji-Heui Seo, Claudia Giambartolomei, Iris de Rink, Roelof J.C. Kluin, Jeroen de Jong, Dorine C. Hintzen, Anniek Zaalberg, Martin Sjöström, Sylvan C. Baca, Yongsoo Kim, Liesbeth Hoekman, Umut Berkay Altintas, Tunc Morova, Chia-Chi Flora Huang, Joyce Sanders, Tesa M. Severson, Elise M. Bekers, Maartje Alkemade, Hilda de Barros, Karianne Schuurman, Nils Eickhoff, Suzan Stelloo, Marlous Hoogstraat, Simon Linder

Supplementary Figure from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f42b86f8b15f67e1989e728942677f1
https://doi.org/10.1158/2159-8290.22541192