Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Elise Landais"'
Autor:
Collin Joyce, Sasha Murrell, Ben Murrell, Oluwarotimi Omorodion, Lorena S Ver, Nancy Carrico, Raiza Bastidas, Rebecca Nedellec, Michael Bick, Jordan Woehl, Fangzhu Zhao, Alison Burns, Shawn Barman, Michael Appel, Alejandra Ramos, Lalinda Wickramasinghe, Kemal Eren, Thomas Vollbrecht, Davey M Smith, Sergei L Kosakovsky Pond, Ryan McBride, Charli Worth, Facundo Batista, Devin Sok, IAVI Protocol C Investigators & The IAVI African HIV Research Network, Pascal Poignard, Bryan Briney, Ian A Wilson, Elise Landais, Dennis R Burton
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011416 (2023)
Vaccination strategies aimed at maturing broadly neutralizing antibodies (bnAbs) from naïve precursors are hindered by unusual features that characterize these Abs, including insertions and deletions (indels). Longitudinal studies of natural HIV inf
Externí odkaz:
https://doaj.org/article/f3290d1bda334e7a969850f0b8f21e00
Autor:
Jonathan Hurtado, Claudia Flynn, Jeong Hyun Lee, Eugenia C. Salcedo, Christopher A. Cottrell, Patrick D. Skog, Dennis R. Burton, David Nemazee, William R. Schief, Elise Landais, Devin Sok, Bryan Briney
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2023)
The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development. Traditional mAb discovery is a costly and labo
Externí odkaz:
https://doaj.org/article/872e188662cf45d480b2e529faf46daf
Autor:
Deli Huang, Jenny Tuyet Tran, Alex Olson, Thomas Vollbrecht, Mary Tenuta, Mariia V. Guryleva, Roberta P. Fuller, Torben Schiffner, Justin R. Abadejos, Lauren Couvrette, Tanya R. Blane, Karen Saye, Wenjuan Li, Elise Landais, Alicia Gonzalez-Martin, William Schief, Ben Murrell, Dennis R. Burton, David Nemazee, James E. Voss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
A vaccine to generate durable HIV broadly neutralizing antibodies (bnAb) from engineered B cells holds promise as an HIV functional cure. Here, the authors show that CRISPR/Cas-modified B cells expressing bnAbs as functional antigen receptors can be
Externí odkaz:
https://doaj.org/article/8f0e41a577a24e6390766e0efaf6153c
Autor:
Jeong Hyun Lee, Catherine Nakao, Michael Appel, Amber Le, Elise Landais, Oleksandr Kalyuzhniy, Xiaozhen Hu, Alessia Liguori, Tina-Marie Mullen, Bettina Groschel, Robert K. Abbott, Devin Sok, William R. Schief, Shane Crotty
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110485- (2022)
Summary: Elicitation of HIV broadly neutralizing antibodies (bnAbs) is challenging because unmutated bnAb precursors are rare and seldom bind HIV envelope glycoprotein (Env) trimers. One strategy to initiate bnAb responses is to use germline-targetin
Externí odkaz:
https://doaj.org/article/febc5c32beba44638475a04645cb2804
Autor:
Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, Michael B. Zwick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis s
Externí odkaz:
https://doaj.org/article/706277bc9dfa4fb4814343163603b088
Autor:
Rym Ben-Othman, Bing Cai, Aaron C. Liu, Natallia Varankovich, Daniel He, Travis M. Blimkie, Amy H. Lee, Erin E. Gill, Mark Novotny, Brian Aevermann, Sibyl Drissler, Casey P. Shannon, Sarah McCann, Kim Marty, Gordean Bjornson, Rachel D. Edgar, David Tse Shen Lin, Nicole Gladish, Julia Maclsaac, Nelly Amenyogbe, Queenie Chan, Alba Llibre, Joyce Collin, Elise Landais, Khoa Le, Samantha M. Reiss, Wayne C. Koff, Colin Havenar-Daughton, Manraj Heran, Bippan Sangha, David Walt, Mel Krajden, Shane Crotty, Devin Sok, Bryan Briney, Dennis R. Burton, Darragh Duffy, Leonard J. Foster, William W. Mohn, Michael S. Kobor, Scott J. Tebbutt, Ryan R. Brinkman, Richard H. Scheuermann, Robert E. W. Hancock, Tobias R. Kollmann, Manish Sadarangani
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Conventional vaccine design has been based on trial-and-error approaches, which have been generally successful. However, there have been some major failures in vaccine development and we still do not have highly effective licensed vaccines for tuberc
Externí odkaz:
https://doaj.org/article/161a4130886644838de4892cc5710d1d
Autor:
Elise Landais, Penny L. Moore
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Broadly neutralizing antibodies (bNAbs), able to prevent viral entry by diverse global viruses, are a major focus of HIV vaccine design, with data from animal studies confirming their ability to prevent HIV infection. However, traditional va
Externí odkaz:
https://doaj.org/article/22343f5feb8d40d2bd681da7189f9fb1
Autor:
Kimmo Rantalainen, Zachary T. Berndsen, Sasha Murrell, Liwei Cao, Oluwarotimi Omorodion, Jonathan L. Torres, Mengyu Wu, Jeffrey Umotoy, Jeffrey Copps, Pascal Poignard, Elise Landais, James C. Paulson, Ian A. Wilson, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3249-3261 (2018)
Summary: Broadly neutralizing antibodies (bnAbs) targeting the HIV envelope glycoprotein (Env) typically take years to develop. Longitudinal analyses of both neutralizing antibody lineages and viruses at serial time points during infection provide a
Externí odkaz:
https://doaj.org/article/714ec341ba7649fd94d27283c71e0704
Publikováno v:
Microorganisms, Vol 9, Iss 2, p 228 (2021)
Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after infection, which poses a major challenge for drug treatment and curative strategies. Many efforts are therefore focused on blocking infection. To this end, bo
Externí odkaz:
https://doaj.org/article/063bda00769d4030aa2b57352a8e213f
Autor:
Deli Huang, Jenny Tuyet Tran, Alex Olson, Thomas Vollbrecht, Mary Tenuta, Mariia V. Guryleva, Roberta P. Fuller, Torben Schiffner, Justin R. Abadejos, Lauren Couvrette, Tanya R. Blane, Karen Saye, Wenjuan Li, Elise Landais, Alicia Gonzalez-Martin, William Schief, Ben Murrell, Dennis R. Burton, David Nemazee, James E. Voss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20304-y
Externí odkaz:
https://doaj.org/article/d00cdcb7706c4616af3cfef8ada576ca