Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Elise Gorseth"'
Autor:
Robert E. McLaughlin, Elise Gorseth, Michael T. Rooney, Ann E. Eakin, Aryun Kim, Asha S. Nayar, Andy S. Tsai, Kerry E. Murphy-Benenato, Alita A. Miller, Jared L. Crandon, David P. Nicolau, Christina M. Blinn, April Chen, David E. Ehmann, Amy Kutschke, Brian Dangel, Sara A. Patey
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:7743-7752
The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs w
Publikováno v:
Biochemical and Biophysical Research Communications. 437:162-167
UMP kinase (PyrH) is an essential enzyme found only in bacteria, making it ideal as a target for the discovery of antibacterials. To identify inhibitors of PyrH, an assay employing Staphylococcus aureus PyrH coupled to pyruvate kinase/lactate dehydro
Autor:
Charles J. Eyermann, Janelle Comita-Prevoir, Brian Noonan, Elise Gorseth, Bolin Geng, Peter Doig, Gloria Anne Breault, Randy Petrichko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6100-6103
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.
Publikováno v:
Antiviral research. 101
Respiratory syncytial virus (RSV) drug discovery has been hindered by the lack of good chemistry starting points and would benefit from robust and convenient assays for high-throughput screening (HTS). In this paper, we present the development and op
Autor:
Brian Noonan, Randy Petrichko, Peter Doig, Bolin Geng, Elise Gorseth, Gloria Anne Breault, Tomas Lundqvist, Charles J. Eyermann, Janelle Comita-Prevoir
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained
Autor:
France Laliberté, Susana Liu, Elise Gorseth, Brian Bobechko, Adrienne Bartlett, Paula Lario, Michael J Gresser, Zheng Huang
Publikováno v:
FEBS Letters. (1-3):205-208
The PDE4 catalytic machinery comprises, in part, two divalent cations in a binuclear motif. Here we report that PDE4A4 expressed in Sf9 cells exhibits a biphasic Mg2+ dose–response (EC50 of ∼0.15 and >10 mM) in catalyzing cAMP hydrolysis. In vitr